Cayman Chemical

Tris-HCl Stock Solution (1 M, pH 8.0) contains filtered Tris-HCl (1 M, pH 8.0). It is ready to use as supplied.

A cyclohexadepsipeptide that has been shown to induce apoptosis in several cancer lines (EC₅₀s ≤ 10 µM) and to decrease the activation of the cell proliferation kinase, ERK (p44/p42); inhibits the multi-drug resistance transporter Pdr5p from S. cerevisiae.

A selective inhibitor of the 20-HETE synthase, CYP4A11, exhibiting an IC50 values of 8.8 nM when tested in human renal microsomes.

An internal standard for the quantification of PGE2-1-glyceryl ester by GC- or LC-MS.

A cell-permeable antagonist of IP3 receptors.

This assay kit provides an accurate and convenient method for screening LO inhibitors. This assay measures the hydroperoxides generated from the incubation of a LO (5-, 12-, or 15-LO) with either arachidonic or linoleic acid.

A selective, cell-permeable inhibitor of calpains (Ki = 0.21 μM for μ-calpain (calpain-1) and 0.37 μM for m-calpain (calpain-2)).

A cell-permeable inhibitor of Mdm2 (Ki = 28 nM); promotes Mdm2 auto-ubiquitination and proteasomal degradation; induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines and inhibits xenograft tumor growth in vivo.

Blocks CYP17A1 by potently inhibiting both the 17α-hydroxylase and the 17,20 lyase activities (IC₅₀ = 18 and 17 nM, respectively); essentially eliminates plasma testosterone while producing a 3- to 4-fold increase in plasma luteinizing hormone.

A phenylpiperidine derivative that potently and selectively inhibits the reuptake of serotonin, blocking the hSERT with a Ki value of 0.72 nM; less effectively blocks the human norepinephrine and dopamine transporters (Ki = 440 and 1900 nM, respectively).

An NSAID that non-selectively inhibits human COX-1 and -2 with IC₅₀ values of 0.35 and 0.82 µM, respectively; also inhibits aldo-keto reductases (e.g., IC₅₀ = 2.39 µM for human aldose reductase).

Source: 10 µg of recombinant C-terminal His-tagged protein expressed in baculovirus expression system Mr: 51 kDa HDAC5 is a Class IIa HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of non-histone...

An orally bioavailable and brain penetrant aminopropyl carbazole that exhibits proneurogenic and neuroprotective activity by preventing apoptosis of newly postmitotic neurons in the subgranular zone of the hippocampal dentate gyrus; promotes survival of neurons in various rodent models of...

An internal standard for the quantification of clozapine by GC- or LC-MS.

Antigen: human BLT1 receptor amino acids 331-352 Host: rabbit Cross Reactivity: (+) human, bovine, and mouse BLT1 receptor Application(s): FC, ICC, IHC, and WB The human BLT1 receptor is a GPCR that mediates the proinflammatory effects of leukotriene B4 (LTB4). Northern blotting reveals that the...

CLA refers to a family of 8 geometric isomers of linoleic acid in which the two double bonds are contiguous. (The predominant form of linoleic acid in nature, 18:ω6, has double bonds at 9 and 12, interrupted by a methylene carbon.) CLA is found in both meat and dairy products, but it is not...

CAS Number: 1228817-38-6 Molecular Formula: C₂₆H₃₆N₆O₃ Formula Weight: 480.6

A potent and selective PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human).

A broad spectrum, orally available kinase inhibitor that targets primarily tyrosine kinases, including VEGFR and EGFR, with IC₅₀ values in the nanomolar range; also potently blocks non-receptor tyrosine kinases, including ABL, RET, and SRC, as well as several serine/threonine kinases.

An analog of LTB4 that binds to the BLT1 and BLT2 receptors with Ki values of 5.1 and 1,227 nM, respectively.

POL is a common triglyceride component in seed and vegetable oils including olive, sesame, soybean, canola, corn, hazelnut, and many others. POL is one of the standard triglyceride components used for the USP analysis of sesame oil for pharmaceutical applications.

A potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity: inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation; inhibits IKK in an number of cells types.

An allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt; inhibits Akt activity in HEK293T cells, promoting cell death; suppresses tumor growth in mice.

An internal standard for the quantification of PEA.