Antigen: human caspase-3 amino acids 166-183
Host: rabbit
Cross Reactivity: (+) human, mouse, baboon, and hamster caspase-3; recognizes both the proform and active subunits of caspase-3
Application(s): WB and IHC
Caspase-3 is a key effector caspase in the apoptosis cascade and is efficiently activated by caspase-8, caspase-9, and granzyme B. DNA fragmentation and the morphological changes associated with this final stage of apoptosis appears to be dependent upon caspase-3.