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The oxidized form of NADPH; serves as a cofactor in various biological reactions.
A fluorogenic substrate for acid and alkaline lipases.
G-1 is a nonsteroidal, high-affinity, selective agonist of GPR30 that binds with a Ki value of 11 nM. Competitive binding studies in endoplasmic reticulum α- (ERα-) and ERβ-expressing cells yielded Ki values for estradiol of 0.30 and 0.38 nM, respectively, with no substantial...
A selective PKC inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC; exhibits PKC isozyme specificity with preference for PKCα over PKCβI, PKCβII, PKCγ, or PKCε (IC50s = 53, 195, 163, 213, and 175 nM, respectively).
A selective inhibitor of Plk1 (IC50 = 0.83 nM); induces mitotic arrest and apoptosis in diverse human cancer cell lines and drives regression of human tumor xenografts in nude mice; also an inhibitor of BRD4 (IC50 = 25 nM).
An isomer of iloprost that inhibits platelet aggregation with an IC 50 value of 65 nM.
An internal standard for the quantification of 4-hydroxy hexenal by GC- or LC-MS.
An ethyl analog of tacrolimus with potent immunosuppressant properties that prevents T-cell proliferation through initial binding to FKBP12, the principal mediator of FK506- and rapamycin-induced immunosuppression; inhibits the enzymatic PPIase and chaperone activities of PfFKBP35 (IC50 = 0.52...
A prodrug analog of 15(S)-15-methyl PGF2α designed for activation by gastric acid after oral administration.
A second generation ACE inhibitor (IC50 = 4 nM) that acts as a prodrug, which in vivo is hydrolyzed to the active metabolite ramiprilat.
A selective, irreversible inhibitor of cytochrome P450 (CYP) 3A isoforms (IC50 values range from 26 to 240 nM for CYP3A4 and CYP3A4/5 from different sources); potently blocks the hydroxylation of testosterone and midazolam by CYP3A4.
PGF2α isopropyl ester is an ester prodrug of PGF2α with enhanced lipid solubility. Due to better membrane penetration, PGF2α isopropyl ester is more suitable than PGF2α or PGF2α tromethamine salt for topical application in studies on intraocular pressure. The ester...
Peptide Sequence: human 15-LO-2 amino acids 163-181 (CLDEKTVEDLELNIKYSTA) To be used in conjunction with Cayman’s 15-LO-2 polyclonal antibody (Catalog No. 10004454) to block protein-antibody complex formation during immunochemical analysis of 15-LO-2.
A potent dopamine receptor agonist that binds the D2 receptor with highest affinity (Ki = 2.5 nM); avidly binds the serotonin receptors 5-HT1A and 5-HT1D (Ki = 12.9 and 10.7 nM, respectively), as well as α and β adrenoreceptors.
An internal standard for the quantification of (R)-BEL by GC- or LC-MS.
A potent, selective full agonist for BLT2 with an EC50 value of 20 nM; activates BLT2 at significantly lower concentrations than LTB4 (EC50 = 170 nM); dose dependently increases intracellular calcium stores and induces ERK phosphorylation in CHO cells expressing BLT2 with no effect on CHO cells...
The primary, active metabolite of aripiprazole.
A selective, orally bioavailable inhibitor of Akt1, 2, and 3 (Kis = 0.08, 2, and 2.6 nM, respectively); inhibits the proliferation of human cancer cell lines with Akt pathway activation and various cell lines derived from hematologic malignancies.
A selective inhibitor of NUAK1 and NUAK2 (IC50s = 20 and 100 nM, respectively); inhibits the phosphorylation of the NUAK1 substrate MYPT1 at Ser445; inhibits proliferation and migration of mouse embryonic fibroblasts and U2OS cells at 10 µM in cell-based assays.
A phytoestrogen that can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity; activates PPARγ (IC50 = 19 µM) and increases the expression of PGC-1α; also inhibits FAAH (IC50...
Antigen: peptide from human TLR1 within the region of amino acids 400-450 Host: rabbit Cross Reactivity: (+) human, mouse, and rat TLR1 Application(s): FC (intracellular and cell surface) and WB TLR1 interacts with TLR2 and coexpression of TLR1 and TLR2 enhances the NF-kB activation in response to a...
An HDAC inhibitor of class I and class II HDACs at around 50 nM; arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.
20-HETE ethanolamide is a potential CYP450 metabolite of AEA, which may be particularly relevant under conditions of FAAH inhibition. Evidence for the formation of 20-HETE ethanolamide in vivo has not been documented.
An irreversible pan-ErbB receptor tyrosine kinase inhibitor (IC50s = 6, 45.7, and 73.7 nM for ErbB1, ErbB2, and ErbB4, respectively); demonstrates antitumor activity in various tumor xenograft models expressing either wild-type ErbB or mutant ErbB family members that show resistance to...