Cayman Chemical

A selective FFAR1 (GPR40) agonist (EC50 = 32nM) that does not exhibit activity on the related FFARs: FFAR2 (GPR43) or FFAR3 (GPR41); increases glucose-stimulated insulin secretion at a concentration of 100 nM in the rat.

A dipyridinyl compound that demonstrates high in vitro and ex vivo selectivity for COX-2 over COX-1.

An irreversible inhibitor of Glut1.

The primary metabolite of PGE2 in plasma which is formed through the 15-hydroxy PGDH pathway.

A synthetic analog of natural PtdIns featuring C16:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as the natural compound.

A dietary triterpene with potent anti-inflammatory, anticarcinogenic, antimutagenic, and antimaralial activity; suppresses the growth of hepatocellular carcinoma cell lines (IC50s ~ 45 μM and melanonma cell lines (IC50s ~ 75 μM), decreases blood pressure in hypertensive rats, and inhibits...

An internal standard for the quantification of linoleic acid by GC- or LC-MS.

A cell-permeable inhibitor of STAT3; induces apoptosis in U87-MG (IC₅₀ = 5.6 µM) and U373-MG (IC₅₀ = 3.7 µM) cells; orally bioavailable, crosses the blood-brain barrier, and demonstrates in vivo activity.

A natural isoflavone which acts as a phytoestrogen; stimulates the growth of estrogen-dependent breast cancer cells in vivo; promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover; increases bone formation in collagen matrix in vivo.

A racemic mixture of hydroperoxides derived non-enzymatically from linoleic acid through the action of reactive oxygen species; has limited direct biological actions, such as the activation of lipoxygenases; normally is rapidly reduced to (±)13-HODE; can also be metabolized to unsaturated...

An affinity probe to allow PGA1 to be detected in complexes with nucleic acid or protein binding partners.

A synthetic PAF analog which contains an ether-linked methyl group at the sn-2 position; decreases plasma membrane fluidity, inhibits tumor cell invasiveness, and causes the release of large quantities of NO by a pathway involving activation of NOS.

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 48.9 kDa

A maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human tumor cell lines carrying tetracycline-regulated mutant p53 (IC₅₀ = 10 µM in vitro) and in vivo.

A nucleoside analog that is incorporated into de novo-synthesized telomeres by telomerase; induces telomerase dysfunction resulting in telomeric DNA damage and rapid cell death.

A 1,5 cyclic ester derived from (±)5(6)-DiHETE.

An anti-inflammatory anthraquinone; inhibits IKKβ (IC₅₀ = 11.8 µM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages; shows efficacy against pancreatic fibrosis, chronic pancreatitis, hyperglycemia-induced pancreatic β-cell apoptosis, and breast cancer...

A ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases.

A FAHFA in which palmitic acid is esterified to 9-hydroxy palmitic acid.

A selective inhibitor of Aurora B kinase (IC₅₀ = 10 µM), less potently inhibiting Aurora C and A (IC₅₀ = 250 and 1,000 nM, respectively); has been used to study the role of Aurora B in molecular events associated with mitosis and cytokinesis; selectively inhibits...

A selective agonist of FFAR3 (IC₅₀ = 117 nM) that does not activate the related receptor FFAR2 at concentrations up to 100 µM; 10 µM stimulates a 1.26-fold increased release of glucagon-like peptide-1 from colonic crypt cultures.

An antibiotic that suppresses the expression of ODC, COX-2, and iNOS at concentrations as low as 0.3 μM and exhibits an anti-metastasis effect and anti-tumor promoter activity in various carcinogenesis mouse models.

Complex I (NADH oxidase/Co-enzyme Q reductase) is one of the major sites of electron entry into the mitochondrial electron transport chain (ETC). Complex I catalyzes the 2 electron oxidation of NADH followed by the reduction of ubiquinone (Q) to form ubiquinol (QH2), and ultimately the reduction of...

Molecular Formula: C₁₀H₈Cl₂N₄OS