Cayman Chemical

A flavonoid compound found in the bark and rinds of many plants and fruits.

This assay system utilizes proprietary human cells engineered to provide constitutive, highlevel expression of the Rat Pregnane X Receptor (nr1i2), a ligand-dependent transcription factor commonly referred to as PXR. PXR is also known as the Steroid and Xenobiotic sensing nuclear Receptor (SXR)....

Oxidized LDL (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the...

A selective histamine H₁-receptor antagonist.

The active circulating metabolite of vitamin D2 formed by 25-hydroxylase in the liver and 25-hydroxyvitamin D-hydroxylase in the kidney.

An endocannabinoid analog that does not bind to CB1, CB2, or TRPV1; at 5 mg/kg antagonizes the hypotensive effects of a 10 mg/kg IV bolus of abnormal cannabidiol (Abn-CBD) in an anesthetized rat blood pressure model; relaxes isolated rat mesenteric arteries and abdominal aorta, and increases the...

An antiviral analog of guanosine, inhibiting the reverse transcriptase of HIV type 1 with an IC₅₀ value of 5.3 μM; blocks retroviral replication.

CAS Number: 444932-31-4 Molecular Formula: C₂₀H₁₉N₃O₄ Formula Weight: 365.4

A selective agonist of S1P3 (EC₅₀ = 72-132 nM); less effectively activates S1P1 (EC₅₀ = 28-38 µM) and is ineffective at S1P2, S1P4, and S1P5 as well as a panel of other receptors, ion channels and transporters.

A protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions.

A member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.

A dual inhibitor of LYPLA1 (IC₅₀ = 17 nM) and LYPLA2 (IC₅₀ = 30 nM); also inhibits the serine hydrolase ABHD11 (IC₅₀ = 10 nM).

An anti-rabbit secondary antibody conjugate

A cell-permeable, selective inhibitor of the HAT p300 (IC₅₀ = 5 µM).

A phospholipid containing the saturated long-chain (18:0) stearic acid inserted at the sn-1 and sn-2 positions.

A more lipid soluble form of carbaprostacyclin; may more readily enter cells to activate PPARδ; may be more amenable for dietary formulations.

Phospholipids used for liposome production in order to study the properties of lipid bilayers.

A potent, highly selective inhibitor of MEK1 and MEK2 (IC50 = 14-99 and 530 nM, respectively); weakly inhibits EGFR (IC50 = 7.0 µM) and has no effect on a large panel of other kinases; suppresses growth and induces apoptosis and differentiation within tumors.

Racemic version of a CYP450 metabolite of arachidonic acid.

An orally-available drug that has shown promise in the treatment of neurodegenerative diseases, including Alzheimer’s and Huntington’s disease.

A negative allosteric modulator of mGlu3 (IC₅₀ = 0.66 μM) that displays 15-fold selectivity over mGlu2 and inactivity against mGlu5.

A potent, selective inhibitor of Hsp90β (IC₅₀ = 58 nM); inhibits proliferation (GI₅₀s from 53 to 190 nM) or induces cell death in cancer cell lines; orally available and has antitumor effects in human tumor xenografts in mice; increases the sensitivity of tumor cells to...

A selective ALK2 inhibitor (IC₅₀ = 1.3 nM) that less potently inhibits ALK1 and ALK3 (IC₅₀ = 2.4 and 85.8 nM, respectively) and demonstrates over 1,500-fold selectivity against the closely related activin and TGF-β type I receptors (i.e., ALK4 and ALK5); inhibits...

An active metabolite of tamoxifen that is formed by the action of CYP2D6 in human liver; inhibits MCF-7 and MDA-MB 231 cell proliferation with IC₅₀ values of 27 and 18 µM, respectively; stimulates LC3 lipidation and formation of autophagic vesicles.