Cayman Chemical

Linolein hydroperoxides are a mixture of 132 possible isomers of mono-, di-, and tri-hydroperoxides produced from the autoxidation of trilinolein. Autoxidation of linoleic acid containing triglycerides (for example, trilinolein) in vivo could result in the formation of these hydroperoxides. Unlike...

A potent inhibitor of DOT1L (IC₅₀ = 0.3 nM); over 100-fold selective over other PMTs; active in cells, reducing H3K79 dimethylation in A431 and MCF10A cells (IC₅₀s = 2.6 and 8.8 nM, respectively).

A prominent member of a class of reactive LO-catalyzed peroxidative decomposition products of unsaturated fatty acids that are formed when diatoms are crushed or eaten.

A multi-target inhibitor that potently blocks EGFR and HER2 (IC₅₀s = 2.4 and 16.4 nM, respectively) and inhibits the activity of class I and class II HDACs at nanomolar concentrations (e.g., IC₅₀s = 4.5, 12.6, 13.2, and 11.4 nM for HDAC1, 2, 4, and 5, respectively).

A kibdelone whose mode of action and pharmacology have not been studied.

A prodrug for colistin (also known as polymyxin E), an antibiotic that is effective against most Gram-negative bacteria but suffers from nephro- and neurotoxicity; used against infections caused by multidrug resistant Gram-negative bacteria.

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human peroxisome proliferator-activated receptor alpha (NR1C1), a ligand-dependent transcription factor commonly referred to as PPARA or PPARα....

A potent inhibitor of DGAT-1 (IC50s = 7 and 24 nM, for human and mouse, respectively); confers significant weight loss within seven days and significantly reduces plasma and liver triglycerides when administered at 3 mg/kg to DIO mice.

An α2-adrenergic receptor agonist (Kd = 7.6 nM for rat cerebral cortex membranes) that has transient antihypertensive effects; used in managing opioid withdrawal symptoms during detoxification from heroin and methadone.

Cayman’s Nitrate/Nitrite Assay provides an accurate and convenient method for measurement of total nitrate/nitrite concentrations. This kit can be used to measure nitrate and nitrite in plasma/serum, urine, tissue culture media, and tissue homogenates. However, it cannot be used to analyze...

The major CYP3A metabolite of midazolam that has been shown to be equipotent to midazolam.

TBS stock solution (10X, pH 7.4) contains filtered concentrated TBS. It is ready to use as supplied.

A synthetic intermediate useful for pharmaceutical synthesis.

Antigen: synthetic peptides corresponding to amino acids 85-99 and amino acids 372-388 of human SMAD6 Cross Reactivity: (+) Human, new world monkey, mouse, rat, and ovine SMAD6; predicted to react with horse SMAD6 Application(s): IHC, WB SMAD6 is an inhibitory SMAD (I-SMAD) that is part of a family...

An orally bioavailable, brain-penetrant inhibitor of MLKs (IC₅₀s = 19, 42, 14, and 150 nM for MLK1, MLK2, MLK3, and the related MLK family member DLK, respectively); also inhibits LRRK2 activity (IC₅₀ = 11 nM); demonstrates anti-inflammatory and neuroprotective effects both in...

A cell-permeable allosteric inhibitor of PAK1 that is non-competitive with respect to ATP binding (IC₅₀ = 2.5 µM); binds covalently to the PAK1 regulatory domain (apparent Kd = 1.9 uM) and prevents binding to the upstream activator Cdc42.

EC 3.1.1.4 Active enzyme isolated from bee venom One unit of enzyme hydrolyzes one µmol of Diheptanoyl Thio-PC per minute at 25°C PLA2 catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, yielding a free fatty acid and a lysophospholipid. PLA2 in bee venom...

An analytical reference material categorized as a phytocannabinoid; intended for research and forensic applications

The diol resulting from the sEH opening of (±)11(12)-EET; contracts artery rings with approximately 70% of the magnitude of (±)11(12)-EET.

An L-type calcium channel blocker that is selective over N-, R-, P/Q- and T-type calcium channels; displays antihypertensive activity, lowering arterial blood pressure without altering cardiac contractility.

An internal standard for the quantification of NAGly by GC- or LC-MS.

A saponin isolated from the root of P. grandiflorum, which has been used extensively in Chinese herbal medicine for many applications.

An internal standard for the quantification of PGDM by GC- or LC-MS.