An orally bioavailable, brain-penetrant inhibitor of MLKs (IC50s = 19, 42, 14, and 150 nM for MLK1, MLK2, MLK3, and the related MLK family member DLK, respectively); also inhibits LRRK2 activity (IC50 = 11 nM); demonstrates anti-inflammatory and neuroprotective effects both in vitro and in vivo.