Select up to 3 products
A polymethoxylated flavone that has been shown to enhance adipogenesis and lipolysis, to inhibit α-glucosidase and α-amylase activity, and to suppress the expression of genes associated with inflammation by regulating IκBα.
A natural anthocyanin that scavenges superoxide anion radicals (IC50 = 69 µM) and protects neurons from oxidative stress; inhibits the ADP-ribosyl cyclase CD38 (IC50 = 6.3 µM), preventing the metabolism of NAD+ and NADP+.
A selective, orally-available antagonist of the 5-HT6 receptor (pKi = 9.02-8.92); produces a significant increase in extracellular levels of glutamate and aspartate within the frontal cortex; used to evaluate the role of 5-HT6 in learning and memory.
A non-nucleoside inhibitor of the RNA-directed RNA polymerase of HCV.
The primary metabolite of mycophenolic acid, an inhibitor of inosine monophosphate dehydrogenase that prevents lymphocyte proliferation and activation; typically used as an internal standard for therapeutic drug monitoring analyses of serum or whole blood by HPLC or LC-MS to confirm that patients...
The 15-deoxy-.DELTA.12,14-PGJ2 Quant-PAK has been designed for the convenient, precise quantification of 15-deoxy-.DELTA.12,14-PGJ2 by GC- or LC-MS. It includes a 50 µg vial of 15-deoxy-.DELTA.12,14-PGJ2-d4 and a precisely weighed vial of unlabeled 15-deoxy-.DELTA.12,14-PGJ2, with the precise...
A synthetic oleanane triterpenoid that blocks iNOS and COX-2 synthesis in INF-γ-activated mouse macrophages (IC50 = 0.4 nM); inhibits proliferation and induces apoptosis in various cancer cell lines and upregulates genes involved in Nrf2/ARE signaling.
BMS-3 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 (IC50s = 5 and 6 nM, respectively). It is used to study the role of activated LIMK isoforms in the signaling of Rho family GTPases to cytoskeletal proteins, including cofilin and tubulin.
A ribonucleotide reductase inhibitor and iron chelator with antitumor activity; inhibits DNA synthesis and repair by destroying the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase through the formation of a redox active complex with iron.
A selective inhibitor of LPCAT2 (IC50s = 0.47 versus 3.02 µM for human LPCAT2 and LPCAT1, respectively) that can suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.
2-Arachidonoyl glycerol (2-AG; Item No. 62160) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor. Incubation of 2-AG with COX-2 and specific prostaglandin H2 (PGH2) isomerases in cell cultures and isolated enzyme preparations...
A flavanonol that suppresses the inflammatory response in mouse models and decreases lipid synthesis in liver cells; regulates gene expression through the ARE in HCT 166 cells and inhibits MMPs, most notably MMP-12 (IC50 = 5.7 µM).
A selective and potent inhibitor of 2,3-oxidosqualene cyclase (OSC) in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively; reduced total cholesterol by 19% in normolipemic hamsters at a dose of 55 mg/kg/day for 11 days and 25% in hyperlipemic hamsters at a dose of...
A lipophilic analog of 17-phenyl trinor PGF2α, a potent agonist for the FP receptor.
The condensation of the dicarboxylate oxaloacetate and acetyl CoA to the tricarboxylate citrate is catalyzed by citrate synthase. It is within this reaction that carbon molecules (as acetyl CoA) obtained from pyruvate oxidation are fed into the tricarboxylic acid (TCA or citric acid) cycle. As a...
A CK2 inhibitor with an IC50 value of 0.8 µM.
A small diffusible signaling molecule produced in Y. pseudituberculosis that is involved in quorum sensing, controlling gene expression, and affecting cellular metabolism.
An atypical, second generation antipsychotic compound that has effects at multiple receptors; antagonizes dopamine D1, D2, and D3 receptors, serotonin 5-HT1A, 5-HT2A, and 5-HT7 receptors, and α1A, α1B, and α2C adrenergic receptors.
An ATP-competitive, selective inhibitor of Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25 and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively.
A cell-impermeant, water-soluble tetrazolium salt used for assessing cell metabolic activity; is reduced by NADH to a water-soluble formazan dye with absorbance max at 460 nm.
Autotaxin (ATX, Ectonucleotide Pyrophosphatase/Phosphodiesterase-2, ENPP-2, Lysophospholipase D) is a secreted lysophospholipase D that catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to generate lysophosphatidic acid (LPA). LPA is a lipid mediator that activates G protein-coupled...
A structural analog of γBB that inhibits γBB hydroxylase (IC50 = 62 µM) and carnitine acetyltransferase (Ki = 1.6 mM); has cardioprotective and neuroprotective effects; improves cognition and reduces amyloid-β pathology in a mouse model of Alzheimer’s disease.
A derivative of AMP that has been used in the synthesis of novel photoaffinity labels for incorporation into DNA and to study adenosine-based interactions during DNA synthesis and DNA damage.
Molecular Formula: C24H28N4O3