Cayman Chemical

A potent, antidiabetic drug of the TZD structural class that lowers blood glucose leves in obese, hyperglycemic, hyperinsulinemic, and insulin-resistant KKAγ mice at a dose of 100 mg/kg for four days; increases the rate of insulin-stimulated lipogenesis in 3T3-L1 adipocytes in a dose-dependent...

A guanosine analog with antiviral properties against DNA and RNA viruses, including RSV, hepatitis C, and influenza; acts as a prodrug that can be activated by either mono- or tri-phosphorylation by cellular kinases.

Host: mouse, clone ICO-115 Cross Reactivity: (+) human CD34 Application(s): (+) ICC and FC; (−) WB CD34 is a type I transmembrane glycoprotein (Mr = 116 kDa). The antigen is expressed on stem cells and early hematopoietic progenitor cells, bone marrow stromal cells, endothelial cells,...

2-methyl-3-Pyrimidin-2-yl-propionic acid is a synthetic intermediate useful for pharmaceutical synthesis.

Cholesterol is the most abundant neutral lipid present in the surfactant of the lung epithelial lining fluid. The double bond between carbons 5 and 6 of cholesterol is susceptible to attack by ozone within this surfactant environment. 6-Oxo-3,5,-diol is a major metabolite of cholesterol formed...

A cell-permeable, reversible inhibitor of exocytosis (IC₅₀ = 20 µM); interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum by dissociating the GTPase activator ARF1 from Golgi membranes.

A phorbol ester that is commonly used to activate certain types of protein PKC and, indirectly, certain MAP kinase pathways; prolonged treatment with PMA produces various effects, ranging from tumorigenesis to hematopoietic differentiation.

An inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis, preventing p53-mediated apoptosis by cytotoxic compounds in C8 cells at 10 μM and in human umbilical vein endothelial cells at 30 μM.

A 3-furyl arachidonoyl analog that acts as a potent and selective reuptake inhibitor of AEA (IC50 = 0.8 µM) but has low affinity for FAAH (IC50 = 30 µM); potentiates the biological effects of AEA when co-administered in rats.

A selective, cell-permeable EZH2 inhibitor (IC₅₀ = 2 nM) that has been shown to inhibit H3K27methylation in MCF10A cells with an IC₅₀ value of 124 nM.

Inhibits the receptor-mediated influx of calcium via voltage-gated calcium channels (IC50 = 10 µM); inhibits the acetylcholine-induced depolarization of circular smooth muscle in a dose-dependent manner at 3-50 µM.

A selective α1A-adrenergic receptor agonist that is at least 35-fold more potent at α1A receptor sites than at α1B or α1D; increases the frequency of spontaneous Ca2+ transients in rat ventricular myocytes in vitro with 330-fold more potency compared to activation by...

An iodinated nonivamide, a potent TRPV1 antagonist with an IC50 value of approximately 10 nM.

Cayman’s Nitrate/Nitrite Fluorometric Assay provides a convenient method for the quantitation of low levels of nitrate and nitrite in biological samples (particularly tissue culture medium). Previously undetectable concentrations of nitrate/nitrite in a variety of samples can be accurately...

CAS Number: 745046-84-8 Synonyms: Ivachtin Molecular Formula: C₂₀H₂₁N₃O₇S

A LPA analog containing stearic acid at the sn-1 position; has potent platelet aggregating activity with an EC50 value of 9 nM.

Binds MDM2 (Ki = 0.88 nM), blocking MDM2-p53 protein-protein interaction, leading to p53-dependent cell cycle arrest and/or apoptosis; induces tumor regression in a SJSA-1 xenograft model of osteosarcoma by upregulating the pro-apoptotic protein PUMA.

Three known isoforms of SREBP transcription factors have been characterized: SREBP-1a, SREBP-1c, and SREBP-2. SREBP-1c acts primarily to activate genes required for fatty acid synthesis, such as acetyl CoA carboxylase, fatty acid synthase, and long chain fatty acid elongase. In addition, SREBP-1c...

A FAHFA consisting of palmitoleic acid esterified at the 5th carbon of hydroxy stearic acid; may be a bioactive lipid with roles in metabolic syndrome and inflammation.

A cell-permeable inhibitor of cathepsin B and L in vivo and in whole cells; used to study the role of cathepsin B in neurodegeneration, cancer cell metastasis, necrosis, and rheumatoid arthritis.

Hydroxymethyl uracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction.

The (S)-enantiomer of medetomidine, an imidazole compound that binds to α2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity; its activation of α2-adrenoceptors produces analgesic, sedative, and anxiolytic effects.

A selective phosphatase inhibitor which prevents dephosphorylation of eIF2α, protecting cells from ER stress-mediated apoptosis (EC₅₀ = 15 μM); prevents replication of herpes virus (IC₅₀ = 3 μM) and alters bone formation.

A degradation product of teicoplanins A2-1 to 5.