Cayman Chemical

A sterol-derived hormone that acts as a ligand of DAF-12 (EC₅₀ = 23 nM; 50 nM, inhibits the dauer-promoting activity of DAF-12, blocking the formation of infective larvae in several parasitic nematodes in favor of reproductive maturation to adults.

The major bioactive constituent of T. wilfordii Hook F., with known antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and antipolycystic kidney disease effects; inhibits human DCTPP1 (Ki = 168 μM; IC50 = 7-10 nM) and COX-2 (IC50 = 0.04 μM).

A type A trichothecene mycotoxin.

This human RAR-related orphan receptor gamma (RORγ) mRNA is expressed from the RORC gene in two forms via alternate usage of tissue-specific promoters. Variant 1 mRNA is expressed in numerous tissues, and encodes receptor isoform 1, referred to as RORγ. Variant 2 mRNA comprises an...

A non-chlorinated analog of OTA that has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion; inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 µg/ml but lacks the genotoxic activity of OTA.

Antigen: native protein purified from bovine brain Host: rabbit Cross Reactivity: (+) human, rat, and mouse synapsin I Application(s): WB

A sympathomimetic β2-adrenoceptor agonist that relaxes bronchial smooth muscle and at higher doses acts as an anabolic steroid, promoting skeletal muscle protein synthesis.

8(R)-HETE is biosynthesized by lipoxygenation of arachidonic acid in marine invertebrates such as gorgonian corals and starfish.

A thiazolidinone that selectively blocks the CFTR channel (Ki = 300 nM) in a voltage-independent manner; prevents cholera toxin-induced fluid secretion in the small intestine, when given by intraperitoneal injection; can affect intracellular GSH concentration and ROS balance.

A proinflammatory monohydroxy oxidation product of arachidonic acid formed by 12(R)-LO.

A selective endothelial lipase inhibitor (IC₅₀ = 237 nM); an oral dose of 30 mg/kg increases HDL cholesterol concentrations by 16% after three days and by 30% after nine days dosing in wild-type mice.

Selectively blocks H-PGDS (IC₅₀s = 0.7 and 32 nM in enzyme and cellular assays, respectively) with little activity against L-PGDS, mPGES, COX-1, COX-2, and 5-LOX; dampens airway hyper-responsiveness in a model of antigen-induced airway response in allergic sheep.

Antigen: human GPR12 amino acids 2-16 Host: rabbit Cross Reactivity: (+) human GPR12 receptor Application(s): FC and ICC

A long-acting, selective β2-adrenergic agonist with bronchodilator actions (EC₅₀ = 0.25 µM) that demonstrates 2,818-fold selectivity for β2-adrenergic receptors over β1-adrenergic receptors.

A potent and selective agonist of the proteinase-activated receptor, PAR2 (pD2 = 7.0); produces a concentration-dependent relaxation of arteries previously contracted with α1 adrenergic receptor agonists.

A RAR antagonist with moderate selectivity for RARβ over RARα (Kis = 0.22 and 1.4 μM, respectively); inhibits retinoid Am80-induced differentiatiobn of HL-60 cells (IC₅₀ = 0.2 μM).

Antigen: purified recombinant CD74 protein Host: mouse, clone PIN1 Cross-reactivity: (+) human CD74 Applications: WB, IP, ICC, and flow cytometry Isotype: IgG1

A protein phosphatase inhibitor that acts as a phosphate group donor in matrix mineralization studies; 10 mM accelerates calcification of cultured vascular smooth muscle cells through an alkaline phosphatase-related mechanism.

Less potent than AEA (Item No. 90050) at the CB1 receptor (Ki = 600 versus 90 nM); inhibits FAAH.

A potent and selective PPARγ antagonist with an apparent IC50 value of 1 nM for the human receptor.

An isomer of valpromide that has been marketed as an anxiolytic and sedative compound; abolishes the activity of MIP synthase in human brain crude homogenates (Ki = 0.18 mM); suppresses electrographic seizures in animal models of status epilepticus.

A more lipid soluble derivative of Tafluprost, a very potent FP receptor agonist (Ki = 0.4 nM).

An inhibitor of Wnt production that impairs Wnt pathway activity (IC₅₀ = 40 nM in vitro) by inactivating Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins; promotes stem cell differentiation.

Cayman’s 8-Isoprostane Affinity Column provides a specific and convenient means for the purification of 8-isoprostane (8-iso PGF2α) from urine and plasma samples. Each column contains 0.5 ml of affinity sorbent (mouse anti-8-isoprostane monoclonal antibody covalently bound to Sepharose...