Cayman Chemical

A cell-permeable substrate for aminopeptidase M and leucine aminopeptidase that was developed for intracellular analysis of protease activities.

A FAHFA in which oleic acid is esterified at the 5th carbon of hydroxy stearic acid.

A potent inhibitor of several CDKs with selectivity for Cdk2 (IC₅₀s = 22, 40, and 200 nM for Cdk2/cyclin A, Cdk1/cyclin B, and Cdk4/cyclin D1); has anti-proliferative and pro-apoptotic activity in tumor cells.

An immunomodulatory and antiproliferative compound that interacts directly with the protein CRBN (IC₅₀ = 8.5 nM), a ubiquitously-expressed E3 ligase, and DDB1 complexes.

A thienylnaphthamide compound that selectively targets the ATP binding site of JNK2 and JNK3 (pIC₅₀s = 6.5 and 6.7, respectively).

A major LO product in PMA-treated murine epidermis.

A selective, orally bioavailable antagonist of the EP1 receptor (Ki = 1.9 nM); suppresses pain associated with cyclophosphamide-induced cystitis in mice.

A PKC inhibitor that displays immunosuppressive activity, blocking T cell activation through the disruption of downstream NF-κB signaling; inhibits PKCα, βI, δ, ε, η, and θ with Ki values of 0.95, 0.64, 2.1, 3.2, 1.8, and 0.22 nM, respectively; also inhibits...

An inhibitor of GLUT1 (IC50 = ~1 µM) that blocks glucose uptake and induces necrosis in cancer cells that lack VHL; inhibits NAMPT, an enzyme that induces GLUT1 expression; toxic to hPSCs and can be used to selectively eliminate hPSCs from mixed cultures.

A selective SGLT2 inhibitor (IC₅₀ = 3.1 nM) that has been shown in clinical trials of patients with type 2 diabetes to lower fasting and postprandial glucose levels by increasing total glucose excretion, improving β-cell function, and shifting substrate utilization from glucose to...

A selective inhibitor of class IIa HDACs, with greater than 170-fold selectivity over class I HDACs, including HDAC1; used in cells (1-10 µM) and in mice to elucidate the roles of class IIa HDACs in cell proliferation and differentiation, apoptosis, myogenesis, adipogenesis, and fibrosis.

A selective p38 MAP kinase inhibitor (IC₅₀ = 44 nM for p38α) that has been shown to reduce inflammatory cytokine production and is neuroprotective following oral administration in vivo.

An affinity probe which allows PGA2 to be detected through an interaction with the biotin ligand.

A probe that reacts stoichiometrically with hydroperoxides to yield the fluorescent molecule DPPP-O; also a fluorescent probe for the detection of LDL and cellular oxidation.

PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate...

A selective inhibitor of the USP1-UAF1 deubiquitinase complex activity (IC₅₀ = 76 nM); potentiates cisplatin cytotoxicity in NSCLC H596 cells and U2OS osteosarcoma cells by targeting the TLS and FA DNA damage response pathways.

The most potent CB1 receptor agonist in the methanandamide series with a Ki value of 20 nM for the CB1 receptor, which is four-fold lower than that of AEA (Ki =78 nM); more resistant than AEA to hydrolytic inactivation by FAAH; binds to the CB2 receptor from murine spleen with a Ki value of 815 nM.

A methylated derivative of PRIMA-1 that restores tumor-suppressor function to mutant p53 and induces cell death in various cancer cell lines; synergizes with chemotherapeutic drugs to induce tumor cell apoptosis.

An orally bioavailable, reversible inhibitor of JAK1 and JAK2 (IC₅₀s = 5.9 and 5.7 nM, respectively) that has been shown to inhibit cytokine-induced phosphorylation of STAT3 in healthy human volunteers.

(1H-Indol-4-yl)-Carbamic Acid tert-butyl ester is a synthetic intermediate useful for pharmaceutical synthesis.

A selective FAAH inhibitor (IC50 = 5.25 nM in rat brain homogenates) with potential analgesic and anxiolytic activity; does not inhibit acidic PEAase or bind to CB1 or CB2 receptors.

An enantiomer of ibuprofen that does not inhibit COX; inhibits NF-κB activation (IC₅₀ = 121.8 µM) in response to T-cell stimulation; blocks superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC₅₀s = 40-100 µM);...

Immunization of mice with chicken egg albumin (ovalbumin/OVA) in a precipitate complex with aluminum hydroxide (alum) is a highly effective means of inducing a potent TH2-mediated immune response. OVA/alum immunized mice produce anti-OVA antibodies predominantly of the IgG1 and IgE isotypes that...

An inhibitor of the NKCC cotransporters, NKCC1 and NKCC2 (Ki ~10 µM for each); commonly used as a loop diuretic.