Cayman Chemical

Source: Active recombinant N-terminal His-tagged enzyme isolated from a HEK293 overexpression system MW: 71 kDa (~16 & 63 kDa purified) PCSK9 is a member of the subtilisin serine protease family with an important role in lipoprotein metabolism. Mutation in the PCSK9 gene is associated with...

A reversible inhibitor of LSD1 (IC₅₀ = 13 nM); allows increased methylation of H3K4, driving increased expression of p21, p27 and CCAAT/enhancer binding protein α in cultured AML cells; improves survival alone and synergizes with panobinostat in improving survival of mice engrafted...

A pan inhibitor PKD (IC₅₀s = 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively); blocks cell proliferation, induces apoptosis, and reduces the viability of pancreatic cancer cells both in vitro and in vivo.

A noncompetitive, allosteric inhibitor of Cdc42 (EC₅₀ = 2.1 µM) with no inhibitory action against Rho, Ras, Rab, or Rac; also inhibits the constitutively active Cdc42 Q61L mutant (EC₅₀ = 2.6 µM).

Antigen: peptide from the C-terminal region of human DAT Host: rabbit Cross Reactivity: human, mouse, and Macaque monkey DAT Application(s): IHC and WB DAT is responsible for the reaccumulation of dopamine after it has been released. DAT antibodies are widely used as markers for dopaminergic and...

A principle lignan present in dietary fiber.

U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against is chemia-reperfusion injury in animal heart, liver, and kidney models.

A selective inhibitor of IKK2 (IC₅₀s = 17.9 nM and 0.40 μM for IKK2 and IKK1, respectively); reduces the severity and onset of collagen-induced arthritis in mice and blocks cytokine release in an antigen-driven rat model of lung inflammation.

8(Z),14(Z)-Eicosadienoic acid is an ω-8 C20:2 fatty acid. The presence of 8(Z),14(Z)-icosadienoic acid has been detected in human milk at a level of 0.19% (weight % total fatty acids). Eicosadienoic acids are converted by desaturases, in vivo, to eicosatrienoic acids, which are potent...

A sulfonic analog of GABA that acts as a competitive antagonist of the GABAB receptor (IC₅₀ = 7.8 µM).

α-CEHC is the major urinary metabolite of α-tocopherol following vitamin E supplementation. The concentration of α-CEHC in human serum is in the range of 5-10 pmol/ml but increases significantly up to 200 pmol/ml upon supplementation with RRR-α-tocopherol. About one-third of...

DL-Cystathionine is an intermediate in the synthesis of cysteine that is produced from homocysteine and serine by the action of cystathionine-ß-synthase (CBS). CBS can also mediate the condensation of cysteine with homocysteine to produce cystathionine and hydrogen sulfide. An excess of...

An internal standard for the quantification of PGD2 by GC- or LC-MS.

Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser294 of human progesterone receptor Host: mouse Cross-reactivity: (+) human Phospho-Ser294 progesterone receptor Applications: WB and IHC (frozen sections)

A fluorescent calcium indicator commonly used in FC and cell-based experiments to detect changes in intracellular calcium levels.

A cell-permeable anilinoquinazoline that blocks the activity of Aurora A (IC₅₀ = 0.39 µM); blocks MCF-7 cells proliferation with an IC₅₀ value of 1.25 µM.

Immunogen: Synthetic peptide from the C-terminal region of human TP Host: Rabbit Species Reactivity: (+) Human, African green monkey, mouse, and rat TP receptor Application(s): FC The TP receptor is a GPCR that mediates the action of TXA2.

A sesquiterpene alcohol found in patchouli oil that has antibacterial, antifungal, and antiviral actions; suppresses inflammation induced by lipopolysaccharide in vivo; accelerates recovery from UV irradiation-induced skin damage through antioxidant and anti-inflammatory effects.

Reactive oxygen species (ROS) react with proteins, resulting in protein modification, such as protein sulfenylation through the reversible oxidation of cysteine residues. Redox-sensitive cysteine residues in proteins can function as sensors of ROS and serve as molecular switches, activating or...

A synthetic quinine derivative commonly used as an anti-malarial drug; also useful in managing SLE, rheumatoid arthritis, and other diseases; inhibits autophagy and induces autophagic cell death (IC₅₀ = 30 µM).

17-phenyl trinor PGE2 is a synthetic analog of PGE2. It is an EP1 and EP3 receptor agonist. 17-phenyl trinor PGE2 is an EP1 and EP3 receptor agonist. It causes contraction of the guinea pig ileum at a concentration of 11 µM. It is slightly less potent than PGE2 in stimulating gerbil colon and...

A selective serotonin reuptake inhibitor (Ki = 6.2 nM in rat hypothalamus) with comparatively little effect on noradrenaline reuptake (Ki = 1,100 nM); potentiates the pharmacological effects of serotonin and its precursor, 5-hydroxy tryptophan, in the CNS resulting in antidepressant effects.

A DR5 agonist (Kd= 1.2 µM; IC₅₀ = 2 µM) that induces DR5 clustering, which leads to the initiation of FADD/caspase-8-dependent apoptosis in various cancer cells.

A selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively; at 10 μM, has negligible effects on a range of other kinases, including other MAP kinases (ERKs, JNKs).