Cayman Chemical

A furanocoumarin isolated from the seeds of P. corylifolia that has been shown to induce cytotoxicity against various cancer cells through TRAIL-mediated events.

A small-molecule agonist of GPR40 (EC50 = 47 nM) and GPR120 (EC50 = 2.2 µM), GPCRs that are activated by medium and long-chain fatty acids; potentiates glucose-stimulated insulin secretion and the KCl-mediated increase in insulin secretion in MIN6 cells.

Immunogen: Synthetic peptide from the N-terminal region of mouse protein LPA3 Host: Rabbit  Species Reactivity: (+) Human, mouse, and rat LPA3 Application(s): ICC and WB LPA3 is a GPCR that mediates many cellular responses including cytoskeletal rearrangements, cell proliferation, and...

An HDAC inhibitor (IC₅₀s = 29 nM, 62 nM, and 1.09 µM for HDAC1, 2, and 3, respectively); possesses preferential binding kinetics with seven-fold longer half-life on HDAC2 compared to HDAC1 (143 min vs. 20 min).

Molecular Formula: C₅₇H₉₂O₆ Formula Weight: 873.4

Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser294 of human progesterone receptor Host: mouse Cross-reactivity: (+) human progesterone receptor; expected to react with mouse, rat, non-human primates progesterone receptor based on 100% homology with the amino...

An imidazole that potently antagonizes the α2-adrenoceptor (Ki = 1.6 nM); shows selectivity over the α1-adrenoceptor (Ki = 13,300 nM) and is a poor antagonist at a wide variety of other receptors and channels.

A multikinase inhibitor that predominantly targets receptor tyrosine kinases, including VEGFR1, VEGFR2, VEGFR3, c-Kit, PDGFR, and RET (IC₅₀s = 2, 3, 6, 8, 84, and 59 nM, respectively); blocks VEGF-induced angiogenesis in the rat corneal model and induces regression of established A431...

A cell-permeable non-steroidal antagonist of GPER, inhibiting activation by either 17β-estradiol or the GPER-selective agonist G-1 (IC₅₀ = 112 and 165 nM, respectively); has no detectable binding activity to either ERα or ERβ.

Glycerol stock solution (20% v/v) contains 20% glycerol. It is ready to use as supplied.

Source: Active mouse recombinant N-terminal His-tagged protein purified from Sf21 cells Mr: 64 kDa sEH catalyzes the hydrolysis of exogenous and endogenous epoxides to vicinal diols. Endogenous substrates for sEH include epoxyeicosatrienoic acids (EETs) which are known for their vasodialatory...

MHY1485 is a cell-permeable activator of mTOR that has been shown to increase levels of cellular mTOR Ser 2448 and downstream substrate 4E-BP Thr 37/46 phosphorylation in rat liver Ac2F cells. It can induce cellular LC3-II accumulation in Ac2F cells and has been shown to inhibit autophagy by...

A selective IDO1 inhibitor (IC₅₀s = 67 and 19 nM for human IDO in enzymatic activity and HeLa cell assays, respectively); decreases kynurenine levels in plasma and dose-dependently reduces the growth of GM-CSF-secreting B16 tumor xenografts in mice at 25-75 mg/kg.

CLA refers to a family of 8 geometric isomers of linoleic acid in which the two double bonds are contiguous. 9(E),11(E)-CLA is the 9,11 all-trans isomer of linoleic acid. CLA was originally identified in ground beef, but it is also present in a variety of dairy products. CLA is effective at reducing...

An analog of oleic acid in which the COOH group is replaced by trifluoromethyl ketone; it’s a potent inhibitor of FAAH, in both human and rat; in transfected COS-7 cells, 10 µM OTK inhibits 95.7% of human FAAH activity and 94.8% of rat FAAH activity.

The second most potent CB1 receptor agonist in the methanandamide series (Ki = 26 nM for the CB1 receptor); less prone to FAAH inactivation and inhibits the murine vas deferens twitch response (IC₅₀ = 47 nM).

A nonselective activator of SK/KCa2 and IK/KCa3.1 channels (EC₅₀s range from 0.12-1.2 µM and 10-90 nM for SK and IK channels, respectively); also activates Kv11.1 channels (hERG; IC₅₀ = 1 µM), but does not affect BK/KCa1.1 channels; modulates neuronal firing...

Features Each vial contains a mixture of standards packaged in amber ampules purged with argon >1 ml provided at the concentration specified in the insert Designed for direct snap and inject use in mass spectrometry applications Ideally suited for method development and as a system suitability...

A natural steroidal alkaloid that inhibits signaling through the Hh pathway at the level of the pathway activator Smo; inhibits Hh-dependent expression of Pax7 with an IC50 value of 24 nM; has potential applications in the treatment of cancer.

Binds Keap1 and attenuates the degradation of Nrf2 at concentrations ≤25 nM, suppressing inflammatory signaling; inhibits tumor cell growth (GI50 = 260 nM), blocks NF-κB signaling, and decreases levels of cyclinD1; activates Nrf2 and provides cytoprotective effects when applied topically.

A fluorescent probe that crosses the blood-brain barrier to bind with high affinity to Aβ plaques (Ki = 10 nM); absorption/emission max at 475/625 nm upon Aβ binding.

An SFA that contains seventeen carbons; used as an internal standard in mass spectrometric methods for total FAs and, more recently, as a biological marker for intake of milk fat SFAs.

An affinity probe for amyloid-β.

Human therapeutic antibodies have become increasingly common components of early drug discovery and development portfolios in the pharmaceutical and biotech industries. As part of preclinical toxicology assessment of these agents, they are routinely tested in non-human primates, primarily in rhesus...