A multikinase inhibitor that predominantly targets receptor tyrosine kinases, including VEGFR1, VEGFR2, VEGFR3, c-Kit, PDGFR, and RET (IC50s = 2, 3, 6, 8, 84, and 59 nM, respectively); blocks VEGF-induced angiogenesis in the rat corneal model and induces regression of established A431 xenografts in mice.