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Cayman’s WST-1 Proliferation Assay is based on the reduction of tetrazolium salt WST-1 to a soluble formazan dye by electron transport across the plasma membrane of dividing cells. This kit will also allow investigators to screen drug candidates involved in cell cycle regulation.
A theoretical metabolite of PGD1.
An endogenous thyroxine metabolite that activates the trace amine-associated receptor 1 at nanomolar concentrations; influences thyroid hormone actions including body temperature, heart rate, and cardiac output as well as balances lipid and glucose utilization.
Antigen: recombinant human PrP Host: mouse, clone 12F10 Isotype: IgG Application(s): IHC and WB
A synthetic intermediate useful for pharmaceutical synthesis.
A potent and selective inhibitor of MEK1/2 (IC50 = 10-100 nM).
11-deoxy-16,16-dimethyl PGE2 is a stable synthetic analog of PGE2. It is an agonist for both EP2 and EP3 receptors. It is an effective inhibitor of gastric acid secretion and ulcer formation in the rat, with ED50 values of 1 mg/kg and 0.021 mg/kg respectively. It is 900 times more potent...
A more hydrophobic form of the free acid, a cytotoxic component from the fruit extract of S. repens.
A reagent that reacts with the primary amine group of PE lipids; facilitates the use of electrospray tandem MS for the detection of diacyl, ether, and plasmalogen PE lipid.
8-iso-15-keto PGF2α is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-iso PGF2α is converted...
A selective inhibitor of TGF-β and activin signaling that suppresses SMAD3 phosphorylation (IC50 = 3 µM); reduces TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.
A cell-permeable, reversible inhibitor of several kinases, including PKCα, PKCβ, PKCγ, Syk, FLK1, Akt,PKA, c-Kit, C-Fgr, c-Src, FLT3, PDFRβ, VEGFR1, and VEGF2, with IC50 values ranging from 80-500 nM.
An inhibitor of the active site of mTOR kinase in both mTORC1 and mTORC2 (IC50 = 8 nM); shown to cause the death of leukemia cells more potently than rapamycin and, in vivo, delays leukemia onset and augments the effects of tyrosine kinase inhibitors in suppressing leukemic expansion and...
DMABA-d10 NHS ester is intended for use in combination with DMABA NHS ester (Item No. 11216) as a derivatizing reagent for PE lipids in order to facilitate MS characterization and to quantify relative changes in their abundance.
A building block for use in click chemistry reactions that enables selective conjugation of peptides with various molecules and can be used for the cyclization of peptides.
An selective inhibitor of JAK2 activity that blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death; blocks growth of all pre-B acute leukemia cells at a concentration of 5 µM.
A small molecule, multi-targeted receptor tyrosine kinase inhibitor; potently inhibits signaling through PDGFR, VEGFR, KIT, and FLT3; inhibits both tumor cell growth and angiogenesis; approved by the FDA for the treatment of gastrointestinal stromal tumor and metastatic renal cell carcinoma.
A CYP450 metabolite of arachidonic acid in the renal and cerebral vasculature; exhibits vasoconstrictor activity.
A sulfated form of taurocholic acid that may be involved in the elimination and detoxification of bile acids during hepatobiliary diseases.
PROLI NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 1.8 seconds at 37°C (pH 7.4) to liberate 2 moles of NO per mole of parent compound.
A common 16-carbon saturated fatty acid that represents 10-20% of the normal human dietary fat intake.
A novel inhibitor of HIF-1a accumulation and gene transcriptional activity; inhibits HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 µM in human Hep3b and AGS cells, respectively.
16,16-dimethyl PGE1 is a metabolically stable synthetic analog of PGE1. It induces human vascular smooth muscle contractions in vitro. It is 2, 3, and 6 times more potent than PGF2α in contracting tracheal, bronchial, and bronchiolar smooth muscle, respectively.
Source: Active human recombinant protein purified from E. coli Mr: 37.3 kDa PTPs remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is of paramount importance to the regulation of...