Cayman Chemical

Immunogen: synthetic peptide from C-terminal region of human optineurin Host: rabbit Species-Reactivity: (+) human optineurin Application(s): WB

An enzyme substrate for glycolysis and gluconeogenesis pathways; metabolized to pyruvate by pyruvate kinase during glycolysis; formed from phosphoenolpyruvate carboxykinase-catalyzed oxaloacetate decarboxylation during gluconeogenesis.

An internal standard for the quantification of PAF C-16 by GC- or LC-MS.

An N-cyanosulphonamide that selectively blocks the sodium/bicarbonate cotransporter (NBC, also known as SLC4A7) with a Ki value of 1.7 µM, with full inhibition occurring at ~30 µM in myocytes; prevents changes in pH associated with depolarization and hyperpolarization of ventricular...

A potent and selective antagonist of the group II metabotropic glutamate receptors mGluR2 and mGluR3 (IC₅₀s = 21 and 14 nM, respectively); less effectively blocks mGluR8 and mGluR7 (IC₅₀s = 173 and 990 nM, respectively) can be effectively used in isolated cells, tissues, and in...

Antigen: human HHATL, C-terminal region Host: rabbit Cross Reactivity: (+) human Application: FC, IF, and WB

Formed by the oxidation of ebselen; lacks antioxidant acitivity.

A brain penetrant inhibitor of wild-type and G2019S mutant LRRK2.

An internal standard for the quantification of 5(Z),8(Z),11(Z)-eicosatrienoic acid by GC- or LC-MS.

A bacterial-derived pentapeptide that irreversibly inhibits aspartic proteases, including pepsin, gastricsin, renin, cathepsin E, and cathepsin D; examined as a therapeutic agent for inflammatory conditions including gastric ulcer, edema, and hypertension.

A cyclic diacyl hydrazide that exhibits chemiluminescence upon oxidation; HRP combined with H₂O₂ causes luminescent peroxidation of luminol; can also be oxidized, and chemiluminesce, by compounds containing iron, copper, gold, and cyanide.

A selective inhibitor of SCFMET30 ubiquitin ligase, an E3 ligase that regulates transcription, cell-cycle control, and immune response; at 5 μM, upregulates a set of methionine biosynthesis genes by altering the SCFMET30 complex, preventing ubiquitination of target proteins, including Met4.

An antagonist of the EP4 receptor (Ki = 1.3 nM) which less potently affects EP3, FP, and TP receptors (Kis = 30, 790, and 2,400 nM, respectively) and is without effect on other prostanoid receptors; implicates EP4 signaling in immune and autoimmune responses, inflammation, and cancer.

An HIV protease inhibitor (Kis = 0.12 and 1 and HIV-2 protease, respectively) that exhibits antiviral activity with low cytotoxicity.

Inhibits recombinant human and mouse sEH (IC50s both = 0.4 nM) and demonstrates a 1,000-fold increase in potency compared to morphine in reducing hyperalgesia in an in vivo carrageenan-induced inflammatory pain model.

A metabolite of PGD2 formed by the elimination of two molecules of water; binds to PPARγ with an EC₅₀ value of 2 µM.

A proton pump inhibitor that irreversibly inactivates the H+/K+-stimulated ATPase pumps in parietal cells, inhibiting gastric acid secretion.

Selective TXA2 receptor antagonist (Ki = 4.1 nM); inhibits U-46619-induced platelet aggregation (IC₅₀ = 0.06 µM).

A quinazolinone-based compound that has been shown to inhibit a VEEV-induced cytopathic effect in three strains of the virus (IC₅₀s = 32, 20, and 41 nM for TC-83, V3526, and Trinidad donkey strains, respectively).

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of full-length, unmodified human androgen receptor (NR3C4), a ligand-dependent transcription factor commonly referred to as AR. INDIGO’s reporter cells...

PBS Stock Solution (10X, pH 7.4) contains filtered concentrated PBS. It is ready to use as supplied.

11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM. 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-6 M which is similar to PGE2. 11β-PGE2 inhibits PGE2 binding to the...

An isomer of 17-phenyl trinor PGF2α ethyl amide wherein the double bond between carbons 5 and 6 has been changed from cis (Z) to trans (E); an impurity in commercial preparations of the bulk drug product.

A FAHFA consisting of stearic acid esterified to 12-hydroxy stearic acid.