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A synthetic analog of natural PtdIns containing C16:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as the natural compound.
An intermediate in the biosynthesis of LEA that can be generated through phospholipase C-mediated hydrolysis of NAPE.
An internal standard for the quantification of acetaminophen by GC- or LC-MS.
Inhibits PANC-1 cell survival in nutrient-deprived media at a 100-fold lower concentration than that required for cells maintained in nutrient-rich media.
A prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling that may activate TRPV1 and TRPV4.
A blue non-fluorescent dye that is used as an oxidation-reduction indicator in cell viability assays in a variety of cells; can be reduced to the highly red-fluorescent product resorufin (excitation: 530-540 nm; emission: 585-595 nm) and used as a quantifiable detection agent in enzyme activity or...
Immunogen: Adenovirus expressing full-length mouse recombinant CD36 Host: CD36 null mouse, clone JC63.1 Species Reactivity: (+) Human, mouse, and rat CD36 Application(s): FC Functioning as a receptor for oxLDL, CD36 is a type-B scavenger receptor that is necessary for the formation of foam cells in...
PPARs are ligand-activated transcription factors belonging to the large superfamily of nuclear receptors. PPARα primarily activates genes encoding proteins involved in fatty acid oxidation, while PPARγ primarily activates genes directly involved in lipogenic pathway and insulin...
An orally bioavailable, ATP-competitive inhibitor of mutant V600E and wild type B-Raf kinases (IC50s = 31 and 100 nM, respectively); inhibits cell proliferation in a variety of cell lines expressing B-RafV600E and is effective against the growth of tumors bearing the B-RafV600E mutation.
A potent inhibitor of Mdm2 interaction with p53 by binding Mdm2 (Ki = 120 nM), in this way activating p53.
A natural alkaloid that inhibits protein synthesis at low micromolar concentrations; immobilizes ribosomes immediately after the initiation of translation.
A saturated 18:0 lysophosphatidylcholine found in plasma and oxidized LDL that is thought to play a role in inflammatory disease and atherosclerosis.
Contains a collection of small, drug-like molecules that inhibit or antagonize epigenetic readers, writers, and erasers each packaged as a 2 mg sample size for ease of preclinical target validation during early stages of drug discovery.
(R)-(−)-2-Phenylglycinol is a synthetic intermediate useful for pharmaceutical synthesis.
A natural 20:0 ceramide that is abundant in the brain; synthesized de novo by ceramide synthases 1 and 2.
An analytical reference standard categorized as a phytocannabinoid metabolite; a cannabidiol metabolite; intended for research and forensic applications
A potent, cell-permeable inhibitor of PKC isoforms (IC50 = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively).
A xanthene commonly used for the fluorometric determination of calcium in solution; can be used in assays that evaluate membrane integrity.
A number of 17-phenyl trinor PGF2α derivatives have been approved for the treatment of glaucoma.{8941,8322,8839,9311} Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side...
The Cayman Chemical 1,2,3-trieicosapentaenoyl glycerol is suitable for use in research facilities and chemical laboratories to conduct wide range of experiments. It is available in sturdy bottle that endures heavy and rigorous usage.
A glutamine analog that inhibits glutaminases (Ki = 6 µM) and other glutamine-utilizing enzymes, including cytidine triphosphate synthase.
An antagonist of MDM2 that suppresses the growth of cancer cell lines expressing wild-type p53 (IC50 values range from 240-440 nM); orally bioavailable, having anti-proliferation as well as apoptotic actions in various tumor models; affects multiple signaling pathways.
GSK2269557 is an inhibitor of PI3Kδ (pKi = 9.9) that is >1,000-fold selective for PI3Kδ over PI3Kα, β, and γ isoforms. It is reported to be active in a brown Norway rat acute ovalbumin-induced allergic asthma model of Th2-driven lung inflammation (ED50 = 67...
A small diffusible signaling molecule produced by wild-type E. carotovora strain SCC 3193 involved in quorum sensing, controlling gene expression, and affecting cellular metabolism.