Cayman Chemical

A natural chalcone that induces apoptosis in prostate cancer cell lines (IC₅₀s = 32, 48, 6.2, and 3.9 µM for LAPC4, LNCaP, PC-3, and DU145 cells, respectively, treated for 48 hours); increases Bim expression and inhibits growth of DU145 xenografts in mice; hepatotoxic.

A polyene macrolide used in the treatment of infections caused by C. albicans, A. fumigatus, and parasitic L. protozoans, as well as in tissue culture to prevent fungi from contaminating cell cultures; binds with ergosterol in fungal cell membranes, altering membrane permeability and ultimately...

15(R)-15-methyl PGF2α methyl ester is a lipid soluble prodrug form of 15(R)-15-methyl PGF2α with increased membrane permeability. Acid-catalyzed epimerization of 15(R)-15-methyl PGF2α methyl ester and hydrolysis of the ester converts it into the active 15(S)-15-methyl PGF2α.

A selective inhibitor of the stress-induced PPP1R15A that does not affect the constitutive PPP1R15B; 50 µM prolongs eIF2α phosphorylation after ER stress, delaying translation which protects cells from misfolded protein-induced cytotoxicity; 1-5 mg/kg prevents defects resulting from...

A macrolide antibiotic with high stability at acidic pH, long half-life, and favorable effectiveness against a range of organisms.

A synthetic peptide (PKTPKKAKKL) corresponding to a sequence of histone H1; phosphorylated by Cdk5 with a Km value of 5 µM.

Maintaining body cholesterol homeostasis is critical for normal physiological functions and is achieved by a highly regulated balance of de novo synthesis, dietary cholesterol absorption, biliary clearance, and excretion. The mechanisms controlling cholesterol absorption are important to understand...

A hydroxamate-based inhibitor of HDACs with an IC₅₀ value of 30 nM; inhibits the growth of colon, breast, prostate, and non-small cell lung cancer cell lines at concentrations of less than 1 µM; augments the actions of fludarabine and imatinib mesylate in human leukemia cells.

An internal standard for the quantification of estriol by GC- or LC-MS.

Selective inhibitor of CYP2C9 (Ki = 0.3 μM); inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.

Antigen: synthetic peptides corresponding to amino acids 186-199 and 509-523 of human SMAD4 Host: rabbit Cross Reactivity: (+) Human, new world monkey, mouse, and rat SMAD4; predicted to react with chicken, bovine, Drosophila, porcine, pufferfish, ovine, Xenopus SMAD4 Application(s): WB SMAD4 is a...

11-deoxy PGE1 is a synthetic analog of PGE1. Early reports show that it is a selective agonist for the EP2 receptor but effective at much higher concentrations than PGE2. However, later studies show that it is a non-selective agonist of EP receptors and stimulates cAMP release in Jurkat cells with...

A glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals; specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA, leading to the destruction of beta cells.

A more lipophilic, stabilized form of HPA.

Ketorolac is a non-selective COX inhibitor. The IC₅₀ values for human recombinant COX-1 and -2 are 31.5 µM and 60.5 µM, respectively.

A water soluble and metabolically stable curaxin that activates p53 with an EC₅₀ value of 0.37 µM and inhibits NF-κB with an EC₅₀ of 0.47 µM; has broad anticancer activity in mice when administered orally.

Sulpho NONOate produces nitrous oxide but no NO at physiological pH. Therefore, this compound may be used as a negative control in experiments using other NO donors of the NONOate class.

A small molecule that selectively increases the level of ROS and apoptosis in cancer cells but not in normal cells at concentrations less than 15 μM; inhibits tumor growth and angiogenesis in established bladder, breast, lung, and melanoma tumor xenografts in mice at 2.4 mg/kg for 2 weeks;...

A cell-permeable, selective inhibitor of N-WASP (IC₅₀ = ~ 10 μM); directly associates with the GTPase-binding domain of N-WASP, preventing its activation by Cdc42 and PIP2; interferes with membrane transport, endocytosis, and neurological development.

A semi-synthetic macrolide antibiotic in which the erythronolide A lactone ring has been altered to prevent inactivation in the gastric milieu; active against Gram-positive and Gram-negative cocci, Gram-positive bacilli, and some Gram-negative bacilli without significantly affecting the fecal flora.

The lipoxins are trihydroxy fatty acids containing a 7,9,11,13-conjugated tetraene. LXA4 was first described as a metabolite of 15-HpETE and/or 15-HETE when added in vitro to isolated human leukocytes. The material obtained in this manner consists of at least four distinct isomers: 5(S), 6(S); 5(S),...

A trypsin-like protease inhibitor known to inhibit trypsin and various inflammatory proteases including plasmin, kallikrein, and thrombin; used in the treatment of chronic pancreatitis and various manifestations of fibrosis.

A potent inhibitor of VEGFR1, 2, and 3 (IC50s = 5, 1, and 3 nM, respectively); also potently inhibits a variety of other receptor and non-receptor tyrosine kinases; blocks tubule formation by HUVECs in vitro and prevents angiogenesis as well as xenograft tumor growth in vivo.

A selective inhibitor of G9a histone methyltransferase (IC₅₀ = 1.7 μM); less effectively inhibits G9a-like protein (GLP; IC₅₀ = 38 μM) and has no effect on other known histone methyltransferases.