Cayman Chemical

A saturated dialkyl glyceryl ether with hexadecyl groups at the sn-1 and sn-2 positions, which mimics the structure of diacylglycerol.

A selective, cell-permeable, quinolone-based inhibitor of Chk1 (IC₅₀ = 0.3 nM versus 0.7 µM for Chk1 and Chk2, respectively); inhibits p53-mutant solid tumor cell growth in synergy with topoisomerase I poisons or ionizing radiation, potentiating tumor apoptosis.

A selective, competitive orthosteric antagonist of the muscarinic M1 receptor (IC₅₀ = 130 nM); is effective in cells and in vivo and brain penetrating, blocking pilocarpine-induced seizures without disrupting contextual fear conditioning in mice.

A 26-carbon saturated (26:0) fatty acid; elevated plasma levels of hexacosanoic acid are found in peroxisomal disorders; increased levels of hexacosanoic acid may also be associated with atherosclerosis and metabolic syndrome.

A natural monoacylglycerol that is metabolized by monoacylglycerol lipase; an agonist of GPR119 (EC₅₀ = 2.5 µM), stimulating the release of glucagon-like peptide-1 from intestinal L-cells.

Reacts with thiols resulting in an increase in fluorescence intensity of up to 120-fold; the response is selective for thiols, occurs in aqueous media, and results in a fluorophore with emission at 623 nm; cell-permeable.

SC-560 is a member of the diaryl heterocycle class of COX inhibitors which includes celecoxib (Celebrex™) and rofecoxib (Vioxx™). However, unlike these selective COX-2 inhibitors, SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes, the IC₅₀ value for...

A number of 17-phenyl trinor PGF2α derivatives have been approved for the treatment of glaucoma. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects....

A reversible, competitive HMG-CoA reductase inhibitor (Ki = 1 nM).

An isothiocyanate derived from glucoraphanin; powerful antioxidant, anti-inflammatory, and anti-carcinogenic effects; at 40 µM, activates Nrf2-mediated gene expression of phase II detoxification enzymes by disrupting the Keap1-Nrf2 complex, allowing Nrf2 to alter transcription.

A form of sphingomyelin containing palmitate (16:0), the most common form of sphingomeylin found in eggs; interacts with cholesterol in lipid rafts; produces C-16 ceramide when processed by sphingomyelinases.

Antigen: human FABP2 amino acids 33-40 Host: rabbit Cross Reactivity: (+) human and rat FABP2; other species not tested but also expected to work with mouse and bovine; (−) recombinant FABP1, 3, 4, and 5 Application: WB; other applications not tested

NADPH is an essential cofactor for the function of the NOS enzyme. Unfortunately, NADPH interferes with the chemistry of the Griess reagents, which are the most commonly used reagents for nitrite detection. This kit uses Lactate Dehydrogenase (LDH) to oxidize the excess NADPH used in a NOS-catalyzed...

(±)5-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The methyl ester of (±)5-HETE has no distinguishing biological activity. Oxidatively degraded PUFA methyl esters may contain (±)5-HETE methyl ester.

Linoleic acid ethyl ester is a neutral, lipid-soluble form of linoleic acid.

Antigen: synthetic peptide from human Histone H3.3 amino acids 100-136 Host: rabbit Cross Reactivity: (+) chicken, ovine, Drosophila, equine, human, mouse, and opossum histone H3.3 Application(s): IHC and WB Histone H3.3 constitutes the predominant form of histone H3 in non-dividing cells and is...

A non-ionic detergent commonly used to solubilize membrane-associated proteins; helps retain the native conformation and activity of membrane-associated proteins, and facilitates the reforming of these proteins after denaturation.

Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH. It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in PRP. In...

A homolog of DHEA, characterized by the addition of an (S)-β-methyl group at the terminal ethanolamine carbon.

HDACs catalyze the hydrolytic removal of acetyl groups from histone lysine residues resulting in chromatin condensation and transcriptional repression of chromosomal DNA. Thus, HDAC inhibition allows the conformation of DNA to be relaxed and transcriptional activation to ensue. Transcriptional...

Blocks the cell surface binding of the CXCR4 ligand CXCL12 (IC50 = 18 nM), inhibits calcium mobilization (IC50 = 4 nM), and (at 6,250 nM) completely blocks chemotaxis of SupT1 cells; active against various HIV strains (IC50s = 6-12 nM).

A selective and competitive inhibitor of NAD+-dependent type-I 15-PGDH (IC₅₀ = 26.4 nM; Ki = 5 nM).

A cell permeable, competitive, and reversible inhibitor of cGKs that blocks activation of cGKI and cGKII by cGMP (Kis = 35 and 30 nM); less potently inhibits PKA (Ki = 11 µM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC₅₀ = 25 µM); resistant to...

A selective agonist of retinoic acid receptor (RAR)-β and RAR-γ (Kds = 34 and 130 nM, respectively) commonly used for the study of the pathogenesis and treatment of acne vulgaris; dose-dependently (0.1-10 µM) inhibits sebocyte growth, proliferation, and differentiation.