Cayman Chemical

15(S)-HEDE is produced from 11Z,14Z-eicosadienoic acid by 15-LO. 15(S)-HEDE is an inhibitor of RBL-1 cell 5-LO with an IC₅₀ value of 26 µM.

Peptide Sequence: HIF-1α protein amino acids (SRNLLQGEELLRALDQVN) To be used in conjunction with Cayman’s HIF-1α Polyclonal Antibody (Item No. 10006421) to block protein-antibody complex formation during immunochemical analysis of HIF-1α.

A selective androgen receptor modulator.

An anti-coagulant; differs from (−)-warfarin by being five times less potent as a vitamin K antagonist; has a longer terminal elimination half-life (35-58 hours) than (−)-warfarin (24-33 hours).

An antagonist of NMDA receptors with high affinity for the glycine binding site (Ki = 140 nM) that is functional both in vitro and in vivo; also an agonist of GPR17 (EC₅₀ values range from 7 nM to 6 µM, depending on the assay).

A phytocannabinoid not present in tobacco smoke; decreases intraocular pressure in rabbits when administered at 1 and 10 mg/kg, i.v.,

Antigen: human GPx4 amino acids 81-93 (TQLVDLHARYAEC) Host: rabbit Cross Reactivity: (+) mouse, rat, and porcine GPx4 Application: WB

An inhibitor of hGIIA sPLA2 (IC₅₀ = 9 nM), as well as mouse GIIA (mGIIA), hGIIE, mGIIE, hGX, and mGX PLA2s, but poorly inhibits other PLA2 enzymes; inhibits serum sPLA2 activity in transgenic mice expressing human sPLA2 when given either intravenously or orally.

A potent, selective agonist of the adenosine A2A receptor (Ki = 11-46 nM); less effective at adenosine A1 and A3 receptors (Kis = 0.5-3.1 and 0.6-1 µM, respectively) and is without effect at adenosine A2B (Ki > 10 µM).

Antigen: N-terminal 80 amino acids of human Trx1 Host: mouse, clone 7D11 Isotype: IgG1 Application(s): ELISA, IF, IP, and WB

Human SIRT1 is the homolog of yeast Sir2 and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Cayman’s SIRT1 FRET-based Screening Assay provides a convenient fluorescence-based method for screening SIRT1 inhibitors or activators. The procedure requires...

(±)9-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 9(S)-HEPE and 9(R)-HEPE. The biological activity of (±)9-HEPE has not been clearly documented.

The inositol phosphates (InsP) play a critical role as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3, more commonly referred to as IP3, is a second messenger produced in cells by PLC-mediated hydrolysis of...

A major component of the teicoplanin complex, a glycopeptide antibiotic produced by A. teichomyceticus that is broadly effective against Gram-positive bacteria.

A stable analog of 2-PG bearing an amide linkage in place of the labile glyceryl ester which endows it with a prolonged in vivo half-life; also an analog of C-16 ceramide; causes apoptosis (IC₅₀ = 80 µM) when incubated with neuroblastoma cells.

A selective β-adrenoceptor agonist that shows high affinity for β1, β2, and β3 (Ki = 224, 458, and 1,570 nM, respectively); inhibits contractions in isolated field stimulated rat vas deferens at low concentrations (EC₅₀ = 45.6 nM); increases cAMP levels and can...

A potent anti-mitotic drug that is 100-fold more active than resveratrol at inhibiting the growth of human colon cancer Caco-2 cells; inhibits tubulin polymerization in a dose-dependent manner (IC₅₀ = 4 μM) and enzymes involved in the synthesis of the polyamines, putrescine, and...

A prohormone of 20-hydroxy ecdysone, an insect-molting, ecdysteroid hormone.

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser642 of rat raf-1 Host: rabbit Cross Reactivity: (+) rat raf-1; expected to react with bovine, canine, chicken, human, mouse, non-human primate, and Xenopus raf-1 Application(s): WB Members of the Raf serine/threonine...

A fungal metabolite that inhibits DGAT activity, preventing triacylglycerol formation (IC₅₀s = 10.2 and 15.5 µM in rat liver microsomes and Raji cells, respectively.

A starting material for the synthesis of nucleosides.

A member of the InsP family of second messengers that potently induces calcium release from permeabilized rat basophilic leukemia cells with an EC50 value of 110 µM.

A natural triterpene that has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and altering lipid metabolism in mice, at least in part through antioxidant actions.

A pyrimidine dicarboxamide that selectively inhibits MMP-13 (IC₅₀ = 8 nM); blocks osterix-dependent calcification of matrices in limb bud cells during endochondral ossification.