Cayman Chemical

3-methoxy PGF1α is a novel analog of PGF1α with a methoxy group in the 3-position of the upper side chain. There are no published reports describing the pharmacology of 3-methoxy PGF1α at this time.

A reversible class I PI3K inhibitor (IC₅₀s = 39, 36, 23, and 383 nM for p110α, δ, γ, and β, respectively); inhibits HER2-overexpressing breast cancer cell proliferation.

A potential trace impurity in commercial preparations of latanoprost.

A natural meroterpene that has retinol-like effects on gene expression and properties of the skin; has antioxidant and antibacterial actions; inhibits DNA polymerase and UDP-glucuronosyltransferase 2B7 (IC50 = 41 µM).

A DHA epoxygenase metabolite found in rat brain and spinal cord that acts as a preferred substrate for sEH (Km = 3.2 µM); demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models and potently inhibits angiogenesis and tumor growth in in vitro assays.

This goat anti-rabbit IgG HRP is used as the 'secondary antibody' for western blotting or ELISA where the primary antibody was generated in rabbits. This peroxidase-conjugated secondary antibody is suitable for western blotting when employing detection by commercially available...

A selective, potent inhibitor of rat FAAH exhibiting a Ki value of 0.14 nM; approximately 580-fold more potent than oleyl trifluoromethyl ketone when assayed under the same conditions.

A potent anti-fungal antibiotic that can directly block nuclear transport by inhibiting the action of CRM1.

A chromogenic PLA2 substrate that contains a palmitoyl thioester at the sn-2 position of the glycerol backbone.

Source: recombinant N-terminal GST-tagged protein purified from E. coli Mr: ~41.7 kDa (15.4 kDa native; 26.3 kDa GST-tagged) PtdIns-(3,4,5)-P3 Binding Protein contains a highly specific PH domain that recognizes and binds PtdIns-(3,4,5)-P3. PtdIns phosphates play a critical role in the generation...

A cell permeable, competitive inhibitor of HIF-1α prolyl hydroxylase; stabilizes HIF-1α expression at normal oxygen tensions in cultured cells at concentrations between 0.1 and 1 mM.

An analog of 3-deazaadenosine, an inhibitor of SAH hydrolase; depletes EZH2 levels and inhibits trimethylation of lysine 27 on histone H3 in primary human AML cells in a dose-dependent manner (0.2-1 μM); acts synergistically with the pan-HDAC inhibitor panobinostat in inducing apoptosis of AML...

A class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC₅₀ = 31.5 nM in guinea pig cardiomyocytes).

An endogenous polyamine required for eukaryotic cell growth and protein synthesis; blocks inward rectifying K+ channels and acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site; scavenges free radicals to prevent DNA damage by ROS.

A potent, selective EP2 receptor agonist (Ki = 73 nM).

Cayman’s PGD2-MOX Express ELISA is a competitive assay that permits the rapid measurement of PGD2 from biological samples, requiring only 1 hour incubation and development times for each step. The methodology for the assay is the same as that employed in the PGD2-MOX ELISA (Item No. 512011)....

A metabolite of the CYP2C19 substrate mephenytoin that has been used for developing UPLC- MS/MS assays for evaluating CYP probe drugs and their relevant metabolites in human urine or plasma samples.

A phospholipid containing the medium-chain (12:0) myristic acid inserted at the sn-1 and sn-2 positions.

A triterpenoid with anti-inflammatory, anti-hyperlipidemic, and hepatoprotective in vivo effects; also has antiviral and anti-tumor actions; binds specific proteins, altering their activity.

A potent antagonist of the PAF receptor, inhibiting aggregation of rabbit and human platelets induced by PAF with IC₅₀ values of 75 and 170 nM, respectively; prevents PAF-induced hypotension in rats, while not blocking hypotension triggered by arachidonic acid, histamine, bradykinin, or...

Acts as a partial agonist at the 5-HT1A receptor (pKi = 7) and interferes to a lesser extent with the binding of dopamine at D1, D2, D3 and D5 receptors, yet has a high affinity for the D4 receptor.

A selective EZH2 inhibitor that has activity against both wild-type and Y641F mutant EZH2 (IC₅₀s = 15 and 13 nM, respectively); blocks cellular H3K27 methylation and activates PRC2-specific gene expression; decreases proliferation, cell cycle arrest, and apoptosis in diffused large B cell...

An intermediate in the biosynthesis of NAD+ that has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in Nampt+/- mice and high-fat diet-induced type 2 diabetes mice.

CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.