Cayman Chemical

Immunogen: Full length recombinant PAD4 protein Clone: 6D8 Host: Mouse Isotype: IgG1 Species Reactivity: (+) Human PAD4 Application(s): ELISA, WB

A pyrazolopyrimidine that acts as a high-affinity positive allosteric modulator of the GABAA receptor, potentiating GABA-activated chloride currents in a dose-dependent and reversible manner; selective for α1 subunits (EC50 = 2.6 nM) as compared with α2, α3, or α5 (EC50 = 24,...

An inhibitor of sumoylation.

An antipsychotic compound that displays high affinity for dopamine receptors (Kis = 2.4, 0.2, and 1.8 nM for D2, D3, and D4, respectively); also has actions as an antagonist, inverse agonist, or channel blocker, with lower affinities, at other receptors and channels.

A chemical chaperone that rescues the trafficking of misfolded proteins and weakly blocks HDAC activity (IC50 = 0.4 mM), leading to cell cycle arrest, differentiation, and/or apoptosis of various tumors.

A small molecule that inhibits the first step of HIV-1 infection by blocking the binding of host cell CD4 with viral gp120 protein (Kd = 21.1 nM; Ki = 24.9 nM).

A natural neurotransmitter and hormone that acts as an agonist of adrenergic receptors (Ki values are 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively).

Antigen: recombinant human FTO Host: mouse, clone FT 86-4 Cross Reactivity: (+) human, mouse, and rat FTO Application(s): ELISA, IP, and WB FTO is associated with type 2 diabetes and positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, and...

A derivative of hydrochlorothiazide, which is a diuretic and antihypertensive agent that increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.

Recombinant protein expressed in E. coli DPY-30 is a component of the MLL1 methylation complex, which interacts directly with Ash2L.

An herbicide that is effective in controlling a broad range of weeds; reportedly causes cancer in certain laboratory animals, has diverse effects on the reproductive system in animals and humans, and disrupts the normal function of the endocrine system.

A potent inhibitor of Nampt (IC₅₀ = 3 nM); induces cell death in the neuroblastoma cell line SH-SY5Y with an IC₅₀ value of 3.8 nM through a process that appears to involve autophagy.

An inhibitor of TACE that inhibits the cleavage of TNF-α, TNFRI (p60), and TNFRII (p80) with IC₅₀ values ranging from 5-100 µM.

An inhibitor of Akt1 translocation that also inhibits hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) (IC50 = 79 µM).

Host: mouse, clone 2C8 Isotype: IgG2b Cross Reactivity: (+) human and mouse MPO Application(s): IF

A selective inhibitor of PDE4 (IC₅₀ = 72 nM) that antagonizes the Hedgehog signaling pathway; activates localized PKA signaling, which, in turn, regulates Gli processing and translocation.

Racemic verion of the epoxide biosynthesized in rat and rabbit liver microsomes by CYP450.

A soluble salt of the macrolide antibiotic suitable for intraperitoneal or intravenous injections.

Fluralaner is an isoxazoline ectoparasiticide.{36084,36085} It potently and selectively inhibits binding of the GABA receptor channel blocker [3H]4'-ethynyl-4-n-propylbicycloorthobenzoate (EBOB) to housefly head membranes, with an IC50 value of 455 pM as compared to an IC50 value of >10 µM for rat...

To be used in conjunction with Cayman’s NAPE-PLD polyclonal antibody (aa 159-172) (Catalog No. 10305) to block protein-antibody complex formation during analysis of NAPE-PLD · N-acylethanolamines (NAEs) are involved in diverse biological processes such as inflammatory regulation,...

Antigen: human 5-OxoETE receptor C-terminal amino acids 408-423 Host: rabbit Cross Reactivity: (+) human, Cos-7 (African green monkey), mouse, porcine, and rat 5-OxoETE receptor Application(s): ICC and WB The 5-OxoETE receptor couples to Gi/o to inhibit cyclic AMP production and to mobilize...

An internal standard for the quantification of (±)-cannabichromene by GC- or LC-MS; intended for research and forensic applications

A potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.3 nM).

A kinase inhibitor.