Cayman Chemical

A dihydropteridinone that inhibits Plk1, Plk2, and Plk3 (IC₅₀s = 0.87, 5, and 56 nM, respectively), inducing mitotic arrest and apoptosis; inhibits proliferation of multiple cancer cell lines (EC₅₀s = 11-37 nM) and prevents the growth of various human carcinoma xenografts in...

The most common form of vitamin K2; has important roles in blood coagulation, bone metabolism, and vascular biology, primarily through their effects on specific proteins; has anticancer effects.

A synthetic intermediate useful for pharmaceutical synthesis.

The metabolic precursor of EPEA, an N-acylethanolamide that inhibits dietary-restriction-induced lifespan extension in wild type and TOR pathway mutant nematodes; also has anti-inflammatory properties.

Saline sodium citrate stock solution (10X, pH 7.0) contains a concentrated solution of filtered saline sodium citrate (SSC) buffer.

A reversible, competitive antagonist of GPR35, blocking activation by the synthetic agonist pamoic acid with a Ki of 12.8 nM; less potently blocks activation of GPR35 by zaprinast (IC50 = 160 nM); shows ~57-fold selectivity for GPR35 over the related receptor GPR55 (IC50 = 9.08 µM).

A metabolite of ethanol produced in the brain that stimulates dopamineric neurons at 0.1 μM.

8-piperazin-1-yl-Isoquinoline (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.

Dihomo-γ-linolenoyl PAF C-16 is a PAF analog which contains dihomo-γ-linolenoate at the sn-2 position rather than the acetate moiety found in PAF C-16. The biological activities of dihomo-γ-linolenoyl PAF C-16 are not known at present, but may be similar to arachidonoyl PAF C-16...

An anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers, commonly used as a 5% topical oral paste; associates with the calcium-binding proteins S100A12 and S100A13, inhibits the release of FGF1, and, at 1 mM, induces changes in the actin cytoskeleton.

Inhibits TNF-α-induced necroptosis in a FADD-deficient variant of human Jurkat T cells with an EC50 value of 10.6 μM; structurally and biologically distinct from other necrostatins as it does not inhibit RIP1 kinase.

An aromatic hydrazine-containing fluorophore that reacts with aldehydes or ketones for fluorescent labeling.

A small molecule activator of p53 that decreases the growth of BL2 Burkitt’s lymphoma and ARN8 melanoma cells; inhibits the deacetylase activity of purified human SIRT1 and SIRT2.

An inhibitor of Nampt and NF-κB pathway activity; potent cytotoxic effects in human breast (IC50 = 7.3 nM) and lung cancer (IC50 = 0.5 nM) cells lines; inhibits the growth of MCF-7 breast cancer tumors and induces regression of NYH small cell lung cancer xenografts in nude mice at 20-50...

A structural analog of several resveratrol derivatives which act as a potent and selective AhR antagonists and agonist.

An analog of latanoprost in which the hydroxyl at C-15 is inverted relative to latanoprost; binds to the FP receptor in the cat iris sphincter muscle with an IC₅₀ value of 24 µM (tested as the free acid); potential impurity in latanoprost bulk drug preparations.

Antigen: human EP1 receptor C-terminal amino acids 380-402 Host: rabbit Application(s): ICC and WB Binding of PGE2 to the EP1 receptor results in an increase in phosphatidyl inositol turnover with subsequent increase in intracellular free Ca2+. Pharmacologically, EP1 receptors mediate contraction of...

An endogenous agonist at NMDA receptors generated through the metabolism of tryptophan in the kynurenine pathway; generates reactive oxygen species, has immunomodulatory actions, and promotes the formation of hyperphosphorylated tau proteins.

An internal standard for the quantification of 5-POHSA by GC- or LC-MS.

A protopanaxadiol that has diverse in vitro and in vivo effects, including cardioprotective, neuroprotective, and anti-inflammatory actions.

A potent, selective, and cell permable inhibitor of PI3K p110b; IC50 value increases from 5 to ~50 nM at ATP concentrations of 50 µM and 1 mM, respectively; inhibits PtdIns-(3,4)-P2 production in platelets with an IC50 value of 50 nM.

A synthetic intermediate useful for pharmaceutical synthesis.

A selective, reversible inhibitor of ALDH2 (IC₅₀ = 29 nM); reduces excessive alcohol drinking in alcohol-preferring rats, prevents self-administration of alcohol in Long-Evans rats, and produces anxiolytic effects.

An unnatural amino acid with intrinsic fluorescence that can be genetically encoded into proteins.