Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser642 of rat raf-1
Host: rabbit
Cross Reactivity: (+) rat raf-1; expected to react with bovine, canine, chicken, human, mouse, non-human primate, and Xenopus raf-1
Application(s): WB
Members of the Raf serine/threonine kinase family function to relay signals from activated Ras to the downstream protein kinases MEK and ERK, which are critical for cellular proliferation, differentiation, survival, and oncogenic transformation. RAf-1 activity is regulated by phophorylation of Ser301 and Ser642.