Cayman Chemical

A dual inhibitor of MRP-1 and BCRP; maximally inhibits MRP-1 in isolated human peripheral blood leukocytes at 200 nM; effective against both human BCRP and the mouse homolog, Bcrp1.

An acyclic sesquiterpenoid that regulates diverse processes in insects; activates the juvenile hormone receptor, known as methoprene-tolerant, with a Kd value of 2.9 nM.

A nicotinamide-nitric oxide ester with vasodilatory and cardioprotective effects; a potassium channel activator that targets vascular NDP-dependent K+ channels and cardiac ATP-sensitive K+ (KATP) channels (EC₅₀ = 10 µM); an NO donor, producing venodilation and pain suppression.

An internal standard for the quantification of BEL by GC- or LC-MS.

Perampanel (Item No. 23003) is an analytical reference standard categorized as an anticonvulsant.{41049} Formulations containing perampanel induce sedation and euphoria at high doses.{48192} Perampanel is regulated as a Schedule III compound in the United States. This product is intended for...

A selective, orally available modulator of S1P1 and SIP5; induces internalization of S1P1, decreases circulating B and CCR7(+) T lymphocytes, and reduces inflammation and disease parameters in three autoimmune disease models.

A BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 bromodomain 2 and BRD4 bromodomain 1 with IC50 values of 98 nM and 0.22 μM, respectively.

The biosynthetic precursor of all other steroid hormones; activates the human progesterone receptor with an EC₅₀ value of 0.5 nM.

A diselenide-bridged amino acid that has both anti- and pro-oxidant actions; can be reduced by low molecular thiols and disulfide reductases to selenocysteine; has cytostatic effects in a range of cancer cell types.

A selective inhibitor of TGF-β RI, with an IC₅₀ value of 59 nM; poorly inhibits TGF-β RII (IC₅₀ = 400 nM), p38 MAPK (IC₅₀ = 740 nM), and MLK7 (IC₅₀ = 1,400 nM); inhibits TGF-β-induced cell growth (IC₅₀ = 89 nM) and Smad...

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the mouse peroxisome proliferator-activated receptor alpha (NR1C1), a ligand-dependent transcription factor commonly referred to as PPARA or mPPARα....

A major component of the root of P. suffruiticosa that at 30 µM inhibits the growth of human hepatocellular carcinoma SK-HEP-1 cells by causing cell cycle arrest and suppressing the activation of NF-κB.

Prolactin is a polypeptide hormone synthesized and secreted by the anterior pituitary gland, placenta, decidua, and by various immune system cells, such as T cells, B cells, and NK cells. It has many functions, including stimulating mammary glands to produce milk (lactation), stimulating surfactant...

A sulfonyl hydrazide that inhibits BCATc (IC₅₀s = 0.81 and 0.2 µM in human and rat, respectively) with 15-fold selectivity over BCATm; blocks calcium influx into neurons (IC₅₀ = 4.8 µM) following inhibition of glutamate uptake and demonstrates neuroprotective...

A specific, pyridinyl imidazole inhibitor of p38 MAPK that inhibits p38 MAPK activity (IC₅₀ = 0.6 µM).

An internal standard for the quantification of 12-PAHSA by GC- or LC-MS.

A potent, orally available inhibitor of the kinase activity of VEGFR2 (IC₅₀ = 0.9 nM); suppresses the growth of VEGF-stimulated HUVECs at nanomolar concentrations; shows significant anti-tumor activity against assorted human tumor xenografts in nude mice.

A HSL compound produced in the marine bioluminescence bacterium V. fischeri.

A naturally-occurring lipid which is produced by the enzymatic removal of the acylated group of sphingomyelin; serves as a substrate for autotaxin to produce sphingosine-1-phosphate; occurs naturally in plasma, is a constituent of lipoproteins, and is increased in some diseases.

A biguanide that exhibits antihyperglycemic activity by increasing glucose utilization and inhibiting hepatic gluconeogenesis; inhibits the mitochondrial respiratory complex I and the mitochondrial ATP synthase; disrupts the unfolded protein response transcription program during glucose deprivation,...

Synonyms: MIBG

PGF1β is the C-9 epimer of PGF1α. It was shown to enhance respiratory rate in experimental animals when administered intravenously.

Formal Name: 3,4-dichloro-N-(1-methylbutyl)-benzamide CAS Number: 7497-07-6 Molecular Formula: C₁₂H₁₅Cl₂NO