Cayman Chemical

A ligand that can be complexed with enzymes, such as purine nucleoside phosphorylase, and receptors, such as G-coupled receptors, in order to study structure-activity relationships; also used to selectively impair transcription.

A semisynthetic analog of taxol that inhibits microtubule disassembly (IC50 = 0.2 μM) and inhibits cell replication (IC50 = 0.13 μM); has applications in breast cancer and hormone-refractory prostate cancer; intended for research applications.

Source: recombinant His-tagged protein purified from E. coli Mr: ~34 kDa PPARα transcriptionally regulates a variety of genes involved in fatty acid metabolism and oxidation, such as acyl-CoA oxidase, enol-CoA hydratase, medium chain fatty acyl-CoA dehydrogenase, fatty acid transport protein,...

A fluorescent affinity probe for amyloid-β.

A metabolite of AEA that is formed by the sequential actions of COX-2 and PGF synthase; reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice.

An isomer of iloprost that potently inhibits platelet aggregation with an IC 50 value of 3.5 nM.

Hemoglobin (Hb or Hgb) is a globular protein found primarily in erythrocytes that carries oxygen from the lungs to tissue where it releases oxygen and then returns carbon dioxide (CO2) from the tissue to the lungs. Hemoglobin also binds CO2, carbon monoxide (CO), and nitric oxide (NO)....

A catatoxic steroid that acts as an agonist of the rodent PXR at µM concentrations; mediates induction of hepatic CYP3A, Oatp2, and Cyp7a1, regulating both xenobiotic and bile acid homeostasis.

A HSL member that is produced by the F2/5 strain of A. vitis, the bacterium responsible for grape crown gall and its resulting loss of agricultural productivity.

A fungal metabolite that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells (IC₅₀ = 0.25-0.5 μM) by blocking the binding of activated STAT3 dimers to DNA; 10-50 μM exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing...

A monounsaturated long chain fatty acid with potential antitumor and p53 inhibitory activity.

A light-generating enzyme that catalyzes an oxidative reaction, using luciferin, ATP, and molecular oxygen to produce oxyluciferin, which yields visible light.

A multimeric enterotoxin that catalyzes the ADP-ribosylation of the Gsα protein, which activates adenylate cyclase and increases the intracellular concentration of cAMP; causes the hypersecretion of chloride and bicarbonate ions, which results in increased fluid secretion and the severe...

A lignan that has numerous effects on isolated cells and cardioprotective effects in vivo.

An analytical reference material that is structurally similar to known phytocannabinoids; precursor of THCVA in Cannabis; intended for research and forensic applications ,

An irreversible, noncompetitive inhibitor of PARP1 that disrupts binding between PARP1 and DNA by interacting with the DNA binding domain; produces rapid apoptosis in the various cancer cell (IC50s = 40-128 μM).

A naturally occurring caffeoyl conjugate with antioxidant and antiradical properties; demonstrates neuroprotective effects (EC₅₀s = 0.9-3.7 µM) in several in vitro models of neuronal death.

An IFNAR2 agonist.

Produced by selective hydrolysis of the terminal saccharide unit of ivermectin; inhibits nematode larval development.

A dihydropyridine that acts as a potent, selective α1A-adrenoceptor antagonist (Ki = 0.16 nM); less potently blocks L- and T-type Ca2+ channels (IC₅₀s = 0.4 and 0.9 µM, respectively).

Source: recombinant N-terminal hexahistidine-tagged protein expressed in E. coli Mr: 19.3 kDa Protein concentration: 1.0 mg/ml

Immunoglobulin IgG provides the majority of antibody-based immunity against invading pathogens and plays a significant role in the pathology of auto-immune diseases. Most mouse monoclonal antibodies are of the IgG isotype. Because mice are widely used as a research model for studies of the immune...

A selective inhibitor of FGFR4 (IC₅₀s = 3, 591, 493, and 150 nM for FGFR4, 1, 2, and 3, respectively); inhibits proliferation of HCC cells (EC₅₀s = 0.02-0.11 µM) and demonstrates antitumor activity in mice bearing HCC xenografts when administered orally at 100 mg/kg.

A mycotoxin produced in food and animal feeds; activates estrogen receptors, alters hormone levels, and hasten pre-pubertal development; can cause uterine, rectal, and vaginal prolapse, abortion, and infertility in older animals.