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A natural oxidative metabolic of the mycotoxin aflatoxin B1; produced from aflatoxin B1 in mammals and then secreted in milk.
An inhibitor of DNA methyltransferases that reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 μM for in vitro anti-myeloma activity) and cancer (IC50s ~ 0.4 μM for inhibiting proliferation of various cancer cell lines).
Cayman’s sPLA2 Assay provides an accurate and convenient method for measurement of sPLA2 activity. This assay uses the 1,2-dithio analog of diheptanoyl phosphatidylcholine which serves as a substrate for most PLA2s with the exception of cPLA2. Upon hydrolysis of the thioester bond at the sn-2...
A noncytotoxic analog of the natural diterpenoid that possesses anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities.
A highly functionalized and biased thiazole used as a heterocyclic building block to specifically modify lead compounds for drug discovery.
Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity. Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular...
A plant-derived steroidal triterpene that induces cell cycle arrest or apoptosis in a range of cancer cell lines; inhibits the growth of several breast cancer cell lines (IC50s = 18-50 nM); suppresses the growth of tumors developed from MDA-MB-231 and 4T-1 breast cancer cells in mice.
Complex III (CoQ cytochrome c oxidoreductase) is an essential protein for mitochondrial oxidative phosphorylation. Complex III functions as both a gatekeeper for mitochondrial respiration, and as a major source of reactive oxygen species III. It accepts electrons from complexes I and II in the form...
15(R)-PGF2α is the C-15 epimer of the naturally occurring mammalian autacoid PGF2α. It has only 25% of the potency of PGF2α in hamster antifertility studies, which may be due to reduced affinity for FP receptors. Compared to PGF2α, 15(R)-PGF2α has a binding affinity of...
Tris-EDTA stock solution (TE) buffer contains a concentrated solution of filtered Tris-EDTA (10X, pH 7.4).
A minor ganglioside with roles in cell proliferation and differentiation, whose expression increases during development and in pathological conditions such as cancer; targeted for therapeutic approaches to prevent malignant properties of tumor cells like melanoma.
A cationic liposome-forming compound used for transfection of DNA, RNA, and other negatively charged molecules into eukaryotic cells.
A potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through NaV channels (IC50s = 4.1 and 5.2 nM, respectively, in frog muscle and squid axon; Kd = 1.8 nM in rat brain), blocking nerve and muscle action potentials.
A salicylanilide compound with antihelminthic actions; specifically inhibits STAT3 (IC50 = 0.25 μM); inhibits the proliferation of Du145 prostate cancer cells, which have constitutively active STAT3 (IC50 = 0.7 μM).
Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser260 of rat TPH Host: rabbit Cross-reactivity: (+) human and rat TPH; expected to react with bovine, canine, chicken, mouse, and zebrafish TPH Application: WB
A specific inhibitor of class I α-1,2-mannosidase (IC50 = 20 mM), a key enzyme for N-glycan processing in the endoplasmic reticulum and Golgi; inhibiting α-1,2-mannosidase with 1-Deoxymannojirimycin generates N-linked oligosaccharides with high mannose content, preventing...
Inhibits aldehyde dehydrogenase 1a2, (IC50 = 300 nM), a testes-specific isoform of the enzyme involved in vitamin A metabolism; suppresses the expression of several genes that are regulated by retinoic acid and are necessary for spermatogenesis.
A potent competitive inhibitor of both Src and Lck (IC50 = 44 and 88 nM, respectively), as well as Csk and Yes; also inhibits RIP-2.
A cell-permeable cGMP analog that binds cGK without activating it, resulting in competitive inhibition; blocks the relaxation of rat tail arteries induced by the nitric oxide donor SIN-1.
A benzoxazolone derivative that causes skeletal muscle relaxation and blocks spasticity in clinical studies; enhances KCa2.2 and KCa3.1 channels (EC50s = 87 and 98 µM, respectively); urinary excretion of its 6-hydroxy metabolite is often used as a probe of CYP2E1 activity in studies...
Early screening of drug candidate’s potential to induce or inhibit CYP2C9 is a critical step in the drug development process. The CYP2C9 Induction Reporter Assay Kit is a novel method to evaluate CYP2C9 induction by drug candidates. Cayman's CYP2C9 Induction Reporter Assay Kit consists of...
ATK is an analog of arachidonic acid in which the carboxyl group is replaced by a trifluoromethyl ketone group. It inhibits the activity of the 85 kDa cPLA2 and the 80 kDa macrophage iPLA2 without altering the activity of the 14 kDa sPLA2s. ATK is useful for differentiating the effects of cPLA2 and...
Source: recombinant N-terminal His-tagged protein expressed in E. coli Mr: 18.8 kDa
A high affinity ligand of CB2 (Ki = 8.5 nM) with little affinity for CB1 (Ki >10000 nM); demonstrates antinociceptive efficacy in the mouse formalin test at 1 mg/kg, an action which is blocked by a CB2-selective antagonist, AM630.