Cayman Chemical

A selective non-peptide inhibitor of CXCR2, inhibiting IL-8 binding to CXCR2 (IC₅₀ = 22 nM).

A cell-permeable inhibitor of EGFR and c-ErbB2 (IC₅₀s = 20 and 79 nM, respectively); inhibits the proliferation of cancer cells overexpressing either c-ErbB2 or EGFR (IC₅₀s = 2.3-2.5 µM).

A selective, irreversible, and cell-permeable competitive inhibitor of proprotein convertases, including furin/SPC1 (Ki = ~1 nM), SPC2/PC2 (Ki = 0.36 nM), SPC3/PC1/PC3 (Ki = 2.0 nM), SPC4/PACE4 (Ki = 3.6 nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki = 0.12 nM).

Several different arachidonoyl amino acids, including NAGABA, have been isolated and characterized from bovine brain. The glycine congener (NAGly) was found to suppress formalin-induced pain in rats. NAGABA also suppresses normal responses to pain, but has not yet been fully characterized.

A selective, reversible LYPLA1 inhibitor (IC₅₀ = 210 nM).

Antigen: synthetic peptide from human Bnc 1 within the region of amino acids 330-380 Host: rabbit Cross-reactivity: (+) chimpanzee, human, and monkey Bnc 1 Application(s): WB Bnc 1 is a 994 amino acid transcription factor specific for squamous epithelium and for the constituent keratinocytes at a...

EPA is an ω-3 fatty acid abundantly available in marine organisms. It is a poor substrate for COX-1. EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases.

A potassium-sparing diuretic that selectively blocks aldosterone activation of the mineralcorticoid receptor (IC₅₀ = 122 nM); indicated for the treatment of hypertension and heart failure.

A potent tubulin polymerization inhibitor that reduces tumor growth in P-388 (leukemia), SK-N-SH (neuroblast), BXPC-3 (pancreas), NCI-H460 (lung), and DU-145 (prostate) cell lines with ED50 values of 0.0029, 0.00025, 0.23, 0.00035, and 0.00072 µg/ml, respectively; disrupts tumor blood flow in...

A non-depolarizing muscle relaxant that competitively blocks cholinergic receptors at the motor end plate of the neuromuscular junction, inducing temporary paralysis.

A potent, selective inhibitor of BTK (IC₅₀ = 1.9 nM); prevents BCR-mediated B lymphocyte proliferation; reduces cytokine levels within joints and ameliorates symptoms in a mouse model of autoantibody-induced arthritis.

A fluorogenic substrate that can be cleaved specifically by group I caspases.

A synthetic analog of natural PC species containing saturated C8:O fatty acids in the sn-1 and sn-2 positions of the glycerol backbone.

Host: mouse, clone IPO-38 Cross Reactivity: (+) multiple species (species- and tissue-unspecific) Application(s): FC, ICC, IHC (frozen and paraffin-embedded sections), and WB PCNA becomes detectable in the G1 phase of the cell cycle and reaches a maximum level of expression during mitosis. PCNA is...

FK-506 is a potent immunosuppressant that forms a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12). This complex inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T-cell activation. SLF is a cell-permeable...

A thiazide-like diuretic that inhibits sodium/chloride cotransporters in the proximal convoluted tubule of the kidney, which prevents the reabsorption of sodium and chloride.

A small molecule that binds to CBFβ and inhibits its association with Runx1 (IC₅₀ = 3.2 µM); blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.

An analog of PGF2α in which the C-1 carboxyl group has been modified to an N-diethyl that is inert to coneal amidase activity.

An inhibitor of PLAP (IC₅₀ = 3.7 μM) that demonstrates high selectivity against the related alkaline phosphatases, TNAP and IAP (IC₅₀s > 100 μM).

α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl protein transferase (FPTase). At concentrations greater than 1 µM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in...

A glycopeptide antibiotic that causes DNA fragmentation; used, in conjunction with a vector carrying the bleomycin resistance protein ble, as a selective agent in the transformation of yeast, plant cells, and mammalian cells.

A 21:5 ω-3 fatty acid present in trace amounts in the green alga B. pennata and in fish oils; can be used to study the significance of the position of the double bonds in ω-3 fatty acids; rapidly inactivates PGHS (COX).

9(S)-HpODE is produced by the action of arachidonate 5-LO on linoleic acid. It can be further metabolized by potato hydroperoxide dehydratase to colneleic acid.

A positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes; inhibits PMV migration stimulated by LTB4 at a concentration of 10-7 M and inhibits LTB4-induced adhesion of PMNs with an IC₅₀ value of ~3 x 10-10 M.