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A selective inhibitor of TGF-β RI, with an IC50 value of 59 nM; poorly inhibits TGF-β RII (IC50 = 400 nM), p38 MAPK (IC50 = 740 nM), and MLK7 (IC50 = 1,400 nM); inhibits TGF-β-induced cell growth (IC50 = 89 nM) and Smad phosphorylation.