Cayman Chemical

A stable analogue of prostacyclin that potently and selectively activates the IP receptor (Ki = 20 nM); the active form of the prodrug NS-398 that is stable in vivo, as plasma concentrations of MRE-269 remain near peak levels for more than eight hours; exhibits lower affinity for the...

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 35.5 kDa

A peptide thiazole antibiotic that inhibits FoxM1 (IC₅₀ = ~5 μM), preventing the expression of FoxM1-regulated genes; prevents proliferation and induces apoptosis in certain types of stem cells as well as cancer cells.

A selective agonist of FXR (EC50 = 15 nM); displays no activity at other nuclear receptors, including the retinoic acid receptor, at concentrations up to 1 μM.

8-iso-15-keto PGE2 is an isoprostane, one member of a large family of biomarkers produced by the free radical peroxidative degradation of membrane lipids. 8-iso-15-keto PGE2 is the theoretical first metabolite of 8-iso PGE2 via the 15-hydroxy PGDH pathway. While a number of potent biological...

An A_2A adenosine receptor antagonist.

8-iso PGF2β is an isomer of PGF2α with a non-enzymatic, non-cyclooxygenase origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery and...

Immunoge: Peptide from the N-terminal region of mouse PEPCK Host: Rabbit Species Reactivity: (+) mouse and rat PEPCK protein Application(s): WB PEPCK catalyzes the conversion of oxaloacetate to phosphoenolpyruvate, the first committed step in gluconeogenesis. Both non-insulin-dependent diabetes...

A cell-permeable benzoxazolo-sulfonamide compound that blocks human FBPase-1 enzymatic activity by competing at the AMP allosteric binding site (IC₅₀ = 3.4 µM; Ki = 1.1 µM); blocks glucose production in starved rat hepatoma cells (IC₅₀ = 6.6 µM).

An internal standard for the quantification of ibuprofen by GC- or LC-MS.

2-Arachidonyl glycerol (2-AG) exhibits CB agonist activity at the CB1 receptor, is an important endogenous monoglyceride species,{6819} and is thus considered to be the natural ligand for the CB1 receptor. 2-AG can also be metabolized by COX-2 to form PG 2-glyceryl esters. In activated RAW 264.7...

GR is a flavoprotein that catalyzes the NADPH-dependent reduction of oxidized GSSG to GSH. This enzyme is essential for the GSH redox cycle which maintains adequate levels of reduced cellular GSH. A high GSH/GSSG ratio is essential for protection against oxidative stress. Cayman’s Glutathione...

A metabolite of caffeine that can be detected in urine as a biomarker of caffeine consumption.

A fibrate that activates PPARα (EC₅₀ = 193 μM) with 100% efficacy and PPARγ (EC₅₀ = 148 μM) with 79% efficacy; lowers triglycerides and increases HDL cholesterol levels; strongly binds liver fatty acid-binding protein (Ki = 1.8 μM).

A pro-apoptotic activator of the apoptosome; activates caspase-3 (EC50 = 5 µM) in a cell free, multi-component assay.

A synthetic prodrug of 1,25-dihydroxy vitamin D2; used to suppress the synthesis and secretion of parathyroid hormone in secondary hyperparathyroidism; stimulates bone growth; inhibits the growth of certain blastomas and prostate cancer cells.

Host: rabbit Cross Reactivity: (+) human Application: ELISA and WB

Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors.{19346,20362} A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been...

A selective nonphosphoinositide inhibitor with favorable solubility in vivo that specifically disrupts PIP3/Akt PH domain binding (IC50 = 27 μM); suppresses PI3K-PDK1-Akt-dependent phosphorylation, which reduces cell viability and induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50...

A thiadiazolidinone that prevents inflammation and neurodegeneration when injected into rat hippocampus concurrently with kainic acid; irreversibly inhibits GSK3β with an IC₅₀ value of 5 nM when used with a one hour preincubation, increasing to 0.1-1 µM without preincubation.

An inhibitor of EGF receptor kinase with an IC50 value of 1 µM in HT-22 cells.

Each vial contains 5 µg of iNOS (murine macrophage) to be used as a standard for WB and electrophoresis. The enzyme has been carefully purified to exclude all unrelated proteins; may not be catalytically active.

Antigen: mouse DP1 receptor N-terminal amino acids 2-21 Host: rabbit Cross Reactivity: human, mouse, and rat DP1 receptors Application(s): IHC and WB DP1 receptor is one of two receptor isoforms for PGD2, a major COX metabolite of arachidonic acid. As a GPCR, the receptor primarily couples to Gs to...

An allosteric, selective inhibitor of MEK1 and MEK2 (IC₅₀s = 19 and 47 nM, respectively); blocks phosphorylation of ERK1/2 across several human cancer cell lines differing in tissue origin and BRAF mutational status (EC₅₀s = 2.5-16 nM); orally available and active in human...