Cayman Chemical

Active recombinant N-terminal His-tagged protein expressed in E. coli JMJD2D catalyzes the demethylation of di- and tri-methylated forms of histone H3 at lysine residue 9 (me2/3), leading to transcriptional repression and activation, respectively.

A potent, non-selective COX-2 inhibitor (IC₅₀ = 0.04 µM); >1,700 times more potent as an inhibitor of COX-2 than COX-1.

A green fluorescent cationic dye (ex/em max 496/520 nm) that is incorporated with a hydrolytic substrate (e.g., proteinase or peptidase substrates) for use as a highly sensitive detection reagent in fluorescence-based enzyme assays.

PGE1 is not a major naturally occurring prostaglandin, but it is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology. The metabolism of PGE1 is normally initiated by oxidation at C-15, resulting in...

A MS-cleavable crosslinking reagent (18Å in length) that contains two intrinsic positive charges, which allow cross-linked peptides to fragment into their component peptides by collision-induced dissociation or in-source decay.

A peptide hormone released from intestinal L-cells upon nutrient consumption that binds the GLP-1 receptor (pIC₅₀ = 8.5) in the pancreas and displays various antidiabetic effects.

An isothiocyanate derived from cruciferous vegetables that has significant antiapoptotic and antioxidant effects in various cancer cells.

A positive allosteric modulator of AMPA receptors.

A cyclic hexapeptide mycotoxin that binds β-tubulin in a vinca domain; blocks microtubule growth, modulates the dynamics of microtubules, and interferes with mitosis.

An upregulator of utrophin expression.

A potent, reversible inhibitor of the p38α isoform of MAP kinase (IC₅₀ = 32 nM) that does not inhibit the p38γ isoform.

An unusual, yet primary, product of the COX pathway biosynthesized by TX synthase in the human platelet.

An orally-active, non-peptidic agonist of GHSR (Kd = 0.4 nM) and, as a result, is a GH secretagogue; elevates GH in dogs after oral doses as low as 0.125 mg/kg, without significantly changing plasma levels of aldosterone, luteinizing hormone, thyroxine, or prolactin.

Ac-YVAD-CHO is a selective inhibitor of IL-1β converting enzyme (ICE; Caspase-1). Caspase inhibitors interfere with the initiation of apoptosis and have numerous possible clinical applications.

A potent, selective, ATP-competitive inhibitor of c-Met (IC₅₀ = 20 nM); induces apoptosis and cell cycle arrest in transformed BaF3 cells and cancer cell lines.

The ethyl ester analog of ochratoxin A.

Source: Active human recombinant N-terminal His-tagged protein purified from Sf21 cells Mr: 64 kDa sEH catalyzes the hydrolysis of exogenous and endogenous epoxides to vicinal diols. Endogenous substrates for sEH include epoxyeicosatrienoic acids (EETs) which are known for their vasodialatory...

An indane derivative of melatonin that displays high binding affinity at both melatonin receptors (Kis = 14 and 45 pM for MT1 and MT2, respectively.

An internal standard for the quantification of PGE2-EA by GC- or LC-MS.

A tyrphostin that targets transforming Bcr-Abl fusion proteins (p185Bcr-Abl, p210Bcr-Abl, as well as normal c-Abl (IC₅₀s = 4.3, 1, and 7.1 µM, respectively, for human proteins); also inhibits EGFR (IC₅₀ = 0.25 µM).

A potent, selective, and cell-permeable inhibitor of the BRPF1 bromodomain (IC₅₀ = 80 nM); disrupts chromatin binding of BRPF1 in a cellular assay by blocking the interaction of BRPF1 with histone H3.3.

An in vitro inhibitor of reverse transcriptases from retroviruses, including HIV-1 and visna (Kis = 20 and 37 nM, respectively); also blocks, in vitro, mammalian and bacterial DNA polymerases.

Urinary creatinine levels are commonly used as an index of standardization for a variety of other tests. Measurement of creatinine clearance is also useful in detecting renal disease and estimating the extent of impairment of renal function. The Cayman Chemical Creatinine (urinary) Colorimetric...

A trisubstituted thiophene that selectively inhibits USP7 and the closely related USP47 (EC₅₀s = 4.2 and 4.3 μM, respectively); accelerates the degradation of the USP7 substrate HDM2 in several multiple myeloma cell lines (EC₅₀ =11 μM).