Cayman Chemical

Tris-borate EDTA stock solution (5X, pH 8.0) contains a concentrated solution of filtered Tris-borate EDTA (TBE) buffer.

A synthetic analog of PGF2α; an FP receptor agonist and a potent luteolytic agent in rats and hamsters; the optically active, 15(R) enantiomer of cloprostenol responsible for the majority of its biological activity; a more lipid soluble form of cloprostenol.

A potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 10 nM; R enantiomer of CAY10595 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD2 with an IC50 value of 7.3 nM.

An agonist of the Gαi-linked dopamine receptors D2, D3, and D4 (Ki = 3.9, 2.2, 0.5, and 5.1 nM for D2S, D2L, D3, and D4, respectively); relatively inactive at the Gαs-linked dopamine receptors D1 and D5, as well as at serotonin and adrenergic receptors.

A 6α-methyl derivative of prednisolone, a variation which reduces its binding to corticosteroid-binding globulin and increases penetration into target tissues; alters gene expression through both the glucocorticoid and mineralocorticoid receptors.

An antibiotic which is used in molecular and cell biology to select for transformed cells expressing the hygromycin resistance gene; kills prokaryotic and eukaryotic cells by inhibiting protein synthesis.

A cell-permeable inhibitor of CaMKKα and CaMKKβ (Ki = 80 and 15 ng/ml, respectively); also blocks autophosphorylation of both isoforms; less potently inhibits CaMKII (IC₅₀ = 10 μg/ml) and is minimally effective against several related kinases.

A conjugate of CNP and α-D-glucose, to be used as a chromogenic substrate for enzymes that target the linkage between CNP and α-D-glucose.

Recombinant N-terminal GST-tagged protein expressed in E. coli DNMT3L is required to stimulate the DNA methylation activity of DNMT3a and 3b through interactions with the catalytic domain of DNMT3a and 3b.

Immunogen: synthetic peptide from the N-terminal region of human SOAT-1/ACAT-1 Host: rabbit Species Reactivity: (+) human, mouse, porcine, and rat SOAT-1/ACAT-1 Application(s): WB SOAT-1/ACAT-1 catalyzes the formation of cholesterol esters from cholesterol and long chain fatty acyl-CoA, and may play...

A principle diterpenoid isolated from A. paniculata that inhibits LPS-induced nitric oxide production in inflammatory macrophages after oral administration to mice (25 mg/kg) or by direct addition to cultured macrophages (IC50 = 35.5 µM); reduces VEGF-induced proliferation of HUVECs; inhibits...

Protein Arginine Deiminase 4 (PAD4) is a guanidino-modifying enzyme that functions as a transcriptional coregulator catalyzing the conversion of specific arginine residues to citrulline. Substrates for PAD4 include histones H2A, H3, and H4. PAD4 autocitrullinates itself at several sites, inhibiting...

An orally active, irreversible inhibitor of the HER2 kinase (IC₅₀ = 59 nM) that also potently inhibits several mutants of HER2.

A fundamental component of glucose metabolism involved in the homeostatic regulation of blood glucose levels by participating in glycolysis, glycogen synthesis, and gluconeogenesis.

DMABA-d6 NHS ester is intended for use in combination with DMABA NHS ester (Item No. 11216) as a derivatizing reagent for PE lipids in order to facilitate MS characterization and to quantify relative changes in their abundance.

An unusual fatty acid that acylates some Myxococcus species, a group of gram-negative bacteria, found mainly in soil and also common to marine and freshwater systems with quorum sensing capabilities.

A chemiluminescent substrate of firefly luciferase which produces light upon oxidative decarboxylation in the presence of ATP.

PAF-AH catalyzes the hydrolysis of the potent biologically-active phospholipid PAF, generating inactive lyso-PAF. Cayman’s PAF-AH assay kit provides an accurate and convenient method for measurement of PAF-AH activity. The assay uses 2-thio PAF which serves as a substrate for PAF-AH. Upon...

A prodrug for A-771726 that regulates T lymphocyte progression through the cell cycle by selectively inhibiting de novo pyrimidine synthesis; used to slow the disease progression of rheumatoid arthritis and as an immunosuppressive agent to prevent rejection of transplant allografts and xenografts.

A potent inhibitor of PI3Kγ, selectively inhibiting the γ isoform (IC50 = 30 nM) better than the α, β, and δ isoforms (IC50 = 0.94, 20, and 20 μM, respectively); inhibits phosphorylation of PKB/Akt in mouse macrophages (IC50 = 228 nM).

A cell-permeable, reversible inhibitor of Rac1 activation by the Rac1-specific guanine nucleotide exchange factors TrioN and Tiam 1 (IC50 = 50 μM); has no effect on the closely related GTPases, Cdc42, and RhoA.

A mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties.

A general inhibitor of all PKC subtypes with structural similarity to the nonspecific PKC inhibitor staurosporine; inhibits PDK1 (IC50 = 14 μM) and PKA (IC50 = 2.94 μM).

A natural naphthoquinone that has allelopathic actions, suppressing growth, photosynthesis, and respiration in plants and other organisms; irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM).