Cayman Chemical

An important second messenger in bacteria involved in biofilm formation, motility, virulence, and cell cycling; also has functions in eukaryotic cells.

An epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo.

A stable isomer of 15(S)-HETE that elicits contraction of isolated pulmonary arteries from rabbits and inhibits the proliferation and migration of PC-3 cells.

Host: mouse, clone 4C3 Isotype: IgG3 Cross Reactivity: (+) human and mouse lysozyme C Application(s): FC and IF

A lipophilic electrophile that has profound effects on oxidative and immunological pathways; activates the transcription factor Nrf2, resulting in heme oxygenase-1 expression and increased glutathione levels; suppresses the expression of pro-inflammatory cytokines and inhibits angiogenesis.

A dual MET/AXL inhibitor.

A broad-spectrum anthelmintic that selectively binds the β-subunit of tubulin, thereby inhibiting intestinal microtubule synthesis in parasites (IC₅₀ = 0.19 µM for Giardia in vitro); also possesses antitumor properties, inducing apoptosis of various human carcinomas.

A natural prenylated chalcone that induces protective detoxification enzymes, at least in part via the Nrf2 pathway; inhibits PDK1 (IC₅₀ = 6.6 μM) but not PKC in an in vitro assay; also can have anti-inflammatory, antioxidant, anti-carcinogenic, and osteogenic effects.

Both inhibits and inactivates, at 100 µM, certain microsomal CYP450 enzymes (CYP2E1 and CYP2B4), but not others (CYP1A2).

A full agonist of the serotonin 5-HT7 receptor (Ki = 0.22 nM) that displays 200- and greater than 1,000-fold selectivity over 5-HT1A (Ki = 52.7 nM) and 5-HT2A (Ki = 326 nM) receptors, respectively; induces relaxation of substance P-induced guinea pig ileum contraction with an EC₅₀ value...

This PGD2-MOX ELISA is based on the conversion of PGD2 to a stable MOX derivative. Treatment of the sample with MOX HCl converts PGD2 into PGD2-MOX, preventing its further chemical degradation. The antiserum used in the assay was developed using conjugates of this derivative and is very specific for...

The naturally occurring enantiomer of equol that demonstrates ER agonist activity similar to that of genistein (EC50 = 85 and 65 nM for human ERα and ERβ, respectively); preferentially binds ERβ (Ki = 0.73 nM) with lower affinity for ERα (Ki = 6.4 nM).

A member of the inositol phosphate family of small, soluble second messengers.

A prodrug formulation of a potent DP-receptor agonist that is designed to enhance corneal absorption; lowers monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing at 0.03 μg demonstrating a much more potent effect compared to the free acid.

CAS Number 1216722-25-6 Molecular Formula C₁₄H₁₄N₄O • HCl Formula Weight 254.3

A non-selective, irreversible COX inhibitor with IC₅₀ values of 0.75 and 1.25 mM for ovine COX-1 and COX-2, respectively.

A selective estrogen receptor (ER) modulator; an ER antagonist in breast tissue, effective in treating early breast cancer; an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues.

An inhibitor of Wnt production that impairs Wnt pathway activity (IC₅₀ = 25 nM in vitro) by inactivating Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins; promotes stem cell differentiation.

tetranor-PGDM is a major metabolite of PGD2 found in human and murine urine. Normal levels of tetranor-PGDM in human and murine urine are 1.5 ng/mg creatinine and 8.1 ng/mg creatinine respectively. Cayman’s tetranor-PGDM ELISA is a competitive assay that can be used for quantification of...

An analog of thymidine that, following phosphorylation by cellular kinases, inhibits the reverse transcriptase of HIV.

The predominant form of selenium found in Brazil nuts, grains, soy beans, and legumes; promotes cell cycle progression and has antioxidant and anticancer activity.

BW 246C is the less active C-8 diastereomer of the DP1 receptor agonist BW 245C. The activity of BW 245C is 70-fold greater than that of BW 246C.

An analog of resveratrol in which the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers; exhibits enhanced inhibition of cell growth and pro-apoptotic activities compared to resveratrol.

A high-affinity CB2 receptor-selective agonist (Kis = 6.4 and 1,043 nM for CB2 and CB1, respectively); inhibits forskolin-stimulated cyclic AMP production in CHO cells transfected with CB2 or CB1 receptors (IC50s = 8.1 nM and 10 µM, respectively).