Cayman Chemical

A potent inhibitor of HCV infection (EC₅₀ = 17 nM) that displays low cytotoxicity of virally-infected human hepatoma Huh7.5.1 cells (CC₅₀ = 21.3 µM); displays good pharmacokinetics in mice when delivered intraperitoneally, with preferential liver distribution without...

Peptide Sequence: human SPHK 1 amino acids 264-274 (DLESEKYRRLG) To be used in conjunction with Cayman’s Sphingosine Kinase 1 polyclonal antibody (Item No. 10006822) to block protein-antibody complex formation during immunochemical analysis of SPHK 1 protein.

A derivative of β-glycyrrhetinic acid a major metabolite of glycyrrhizin, one of the main constituents of licorice, with anti-ulcerative and anti-inflammatory properties; inhibits 11β-HSD1 conversion of cortisol to cortisone, which contributes to its potential to induce mineralocorticoid...

An irreversible inhibitor of BMX (IC₅₀ = 8 nM) and BTK (IC₅₀ = 10.4 nM); inhibits the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells (GI₅₀ = 25 nM), as well as RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines (GI₅₀s = 2.54, 4.38,...

A racemic mixture of two optically active isomers, the R and S forms; has a half-life of 36-42 hours in circulation, bound to plasma proteins, and accumulates in the liver, where the two isomers are metabolized by different pathways; also used as a rodenticide.

Antigen: synthetic peptide corresponding to human NF-κB (p65) amino acids 526-539 Host: mouse, clone 112A1021 Isotype: IgG1κ Cross-Reactivity: (+) human, mouse, and rat NF-κB (p65) Application(s): ELISA The active nuclear form of the NF-κB transcription factor complex is...

An analytical reference standard categorized as a phytocannabinoid; intended for research and forensic applications

An inhibitor of ADAMTS-5 (aggrecanase-2; IC₅₀ = 1.1 µM) with 40-fold selectivity over ADAMTS-4 (aggrecanase-1).

A number of 17-phenyl trinor PGF2α derivatives have been approved for the treatment of glaucoma.{8941,8322,8839,9311} Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side...

An FGFR inhibitor.

Potent HDAC6 inhibitor (IC₅₀ = 15 nM) with 1,000-fold selectivity against all other HDAC isoforms (IC₅₀s > 16 μM), excluding HDAC8 (IC₅₀ = 0.9 μM); displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.

A cationic porphyrin that intercalates into and stabilizes G-quadruplexes; inhibits telomerase activity (IC₅₀ ≤ 50 µM), blocking the clonogenic growth and migration of cancer cells in culture and in vivo.

A main phase II metabolite of naringenin that is detectable in urine.

A potent and selective antagonist of the serotonin receptor 5-HT2A (Ki = 0.36-0.85 nM); weakly binds 5-HT2C, α1-adrenergic, and sigma receptors (Ki = 88, 128, and 87 nM) and much less effectively associates with other serotonin, dopamine, adrenergic, muscarinic acetylcholine receptors and...

GDC-0623 is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki = 0.13 nM in the presence of ATP). It inhibits the proliferation of A375 BRAF(V600E) and HCT116 KRAS(G13D)-mutant cancer cell lines with EC₅₀ values of 7 and 42 nM, respectively. GDC-0623 inhibits ERK and BIM phosphorylation...

A competitive α1- and α2-adrenergic receptor antagonist with peripheral vasodilator and histamine-like effects in animal models.

A mycotoxin first isolated from P. roqueforti that displays neurotoxic properties; activates a P-glycoprotein transport system involved in the efflux of xenobiotics and inhibits cytochrome P450 3A detoxification enzymes.

An initial metabolite of LTB4 with significantly reduced biological activity.

A racemic mixture of the fatty acid hydroperoxide product formed from LO action on linoleic acid; shows antimicrobial activity against various fungal and bacterial pathogens.

Pinolenic acid is a PUFA found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was...

Cayman’s Lipid Droplets Fluorescence Assay Kit can be used to study regulators of lipid droplet biogenesis. The main advantage of this assay is that the green fluorescence of Nile Red is both very sensitive and specific for lipid droplets. Furthermore, changes in lipid droplet biogenesis in...

Hexanolamino PAF C-16 is a PAF analog with mixed PAF receptor agonist/antagonist properties. In human monocyte-derived macrophages, it is an antagonist which inhibits the production of reactive oxygen species in response to PAF C-16. On the other hand, in rabbit platelets and guinea pig macrophages,...

PGF2α tromethamine salt is a crystalline derivative of PGF2α with increased water solubility. Its solubility in PBS is 25 mg/ml compared to 10 mg/ml for PGF2α.

A form of thymidine in which the hydroxyl group on carbon 5 of ribose has been replaced with hydrogen and cannot be phosphorylated; competitively inhibits the cellular influx of thymidine.