Cayman Chemical

An internal standard for the quantification of 2-AG by GC- or LC-MS.

The oxygen consumption rate (OCR) of cells is an important indicator of normal cellular function. It is used as a parameter to study mitochondrial function as well as a marker of factors triggering the switch from healthy oxidative phosphorylation to aerobic glycolysis in cancer cells. Oxygen...

An sGC stimulator that increases the activity of sGC in vitro by up to 73-fold and acts in synergy with nitric oxide to increase sGC activity up to 122-fold; promotes vasodilation in several pre-clinical animal models of hypertension and has been evaluated in phase II and III clinical studies of...

A free radical scavenger with diverse protective effects in vivo; reduces damage due to ischemia-reperfusion injury in lung, liver, and brain in animal models of transplant, infection, traumatic brain injury, and stroke.

Active recombinant N-terminal GST-tagged protein expressed in E. coli • G9a-like protein (GLP) is a SET domain-containing methyltransferases that specifically mono- and di-methylate histone H3 at lysine 9 (H3K9).

The isopropyl ester prodrug of AL 6556, a PGD2 receptor agonist (Ki = 3.2 µM, EC50 = 0.80 µM); produces a maximum 53% drop in IOP of the ocular hypertensive monkey with a 1 µg dose given twice daily.

A potent, orally available inhibitor of CDKs, blocking the Cdk9 activity of P-TEFb (IC50 = 8 nM) as well as all other CDK isoforms (IC50 = 100-300 nM); less effectively inhibits EGFR and PKA (IC50 = 21 and 122 μM, respectively); has potential applications in cancer therapy.

Antigen: human irisin amino acids 1-112 Host: rabbit Cross-Reactivity: (+) human; other species not tested Application(s): ELISA and WB

CP 945,598 (hydrochloride) is a selective antagonist of the cannabinoid receptor CB₁ with a Ki value of 0.7 nM and demonstrates relatively low affinity for CB₂ receptors (Ki = 7.6 µM). It is reported to reverse cannabinoid agonist-mediated responses (i.e.,...

A ferric porphyrin complex that causes the decomposition of peroxynitrite by catalytic isomerization to produce nitrate both in vitro and in vivo, resulting in cytoprotection (EC₅₀ = 5 µM).

A ratiometric fluorescent calcium indicator that is amenable to a single excitation source, typically 349-364 nm light from an argon-ion laser; emission maximum shifts from 475-485 nm without calcium to 400-410 nm when indo-1 binds calcium.

An internal standard for the quantification of 17(R)-RvD1 by GC- or LC-MS.

A cell-permeable green fluorescent dye (excitation and emission maxima are 494 and 520 nm, respectively); used to analyze cell proliferation and track cell migration in vivo.

CIQ is a substituted tetrahydroisoquinoline that acts as a subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. It is without effect at subunits NR2A, NR2B, or glutamate receptors. CIQ enhances receptor responses two-fold (EC₅₀ = 3 µM) by increasing channel...

A salen-manganese complex with catalase and SOD mimetic activity.

A methylated form of α-linolenic acid.

A brominated derivative of guanosine that has been used to reduce the conformational heterogeneity of RNA to potentially enhance its function; reported to activate lymphocytes through an intracellular mechanism to exert immunostimulatory effects.

A commonly-used spin trap that reacts with O-, N-, S-, and C-centered radicals, allowing their characterization by electron spin resonance and immuno-spin trapping; is water-soluble, rapidly penetrates lipid bilayers, has low toxicity, and can be used both in vitro and in vivo.

Interleukin-6 (IL-6) is produced by multiple cell types, including monocytes, macrophages, and T cells and is involved in many defense mechanisms including the immune response, hematopoiesis, bone metabolism, and acute phase reactions. IL-6 promotes the proliferation of activated B-cells, acts as a...

A very potent inhibitor of sEH (IC₅₀ = 0.5 nM); displays high oral bioavailability for doses ranging from 0.01 to 1 mg/kg; with the COX-2 inhibitor celecoxib, suppresses tumor angiogenesis, inhibiting tumor growth and metastasis in a Lewis lung carcinoma model in mice.

A water-soluble, slow-releasing H2S donor which demonstrates vasodilator and anti-hypertensive activity in hypertensive rats when given intravenously; also protects against endotoxic shock in rats, inhibiting pro-inflammatory signaling.

A third generation fluoroquinolone with antibacterial activity; inhibits type II topoisomerases (IC₅₀s = 8.06 and 9.81 µg/ml for DNA gyrase and topoisomerase IV, respectively).

Phytochemical from cruciferous vegetables that demonstrates anticancer and chemopreventative effects (10-30 µM) involving the induction of Phase 2 enzymes, promotion of apoptosis, induction of cell cycle arrest, inhibition of cell proliferation, and inhibition of histone deacetylases and DNA...

2-AG has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor. Incubation of 2-AG with COX-2 and specific PGH2 isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glycerol ester formation. The...