Cayman Chemical

A selective, irreversible inhibitor of the paracaspase MALT1, an endopeptidase that targets BCL10 and reduces NF-κB activation in lymphocytes at 12.5 to 75 µM.

(±)18-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 18(S)-HEPE and 18(R)-HEPE. Specific biological activity attributed to (±)18-HEPE has not been documented.

A thienopyridine prodrug that is converted by esterases to a receptor antagonist for purinergic P2Y12 receptors, preventing platelet aggregation.

A selective activator of AMPK; inhibits synthesis of fatty acids and sterols in hepatocytes and insulin-stimulated glucose uptake in adipocytes.

An L-type channel blocker that has negative inotropic and vasodilatory effects at 1 μM.

A synthetic, less hydrophobic phospholipid that has been found to be useful for enhancing the absorption of peptide drugs and hormones such as insulin.

β-HB is a "ketone body" which is produced in the liver, mainly from the oxidation of fatty acids, and is exported to peripheral tissues for use as an energy source. Normally ketosis can indicate that lipid metabolism has been activated and the pathway of lipid degradation is intact....

A monosialoganglioside important for neuronal plasticity and repair mechanisms, as well as for the release of neurotrophins in the brain; acts as the site of binding for both cholera toxin and E. coli heat-labile enterotoxin.

Ins(4)P1 is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3, is a second messenger produced in cells by PLC-mediated hydrolysis of...

Immunogen: synthetic peptide from an internal region of mouse protein Host: rabbit Cross Reactivity: (+) human, mouse, and rat sPLA2 (mouse type V); (−) bee venom and human synovial sPLA2, iPLA2, and cPLA2 Species Reactivity: (+) Human, mouse, and rat sPLA2 Application(s): WB

Source: 50 µg of full length recombinant N-terminal GST-tagged protein expressed in baculovirus expression system Mr: 159 kDa HDAC6 is a Class II HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of...

A potent inhibitor of PI3K with selectivity for the g isoform; inhibits human recombinant PI3Kg, a, d, with IC50 values of 30, 940, 20,000, and 20,000 nM, respectively.

Antigen: human SUCNR1 amino acids 100-150 Host: rabbit Cross Reactivity: (+) human, chimpanzee, new world monkey SUCNR1; predicted to react with dog, mouse, and rat SUCNR1 Application(s): IHC and WB SUCNR1 is a receptor for the citric acid cycle intermediate succinate that functions in establishing...

Ins(1,4)P2 can be dephosphorylated to Ins(4)P by inositol polyphosphate 1-phosphatase and further dephosphorylated to inositol by inositol monophosphatase.

A REV-ERB agonist that increases the constitutive repression of genes regulated by REV-ERBα and REV-ERBβ (IC50s = 670 and 800 nM, respectively); decreases circadian locomotor activity during the dark phase and alters the expression pattern of core clock genes and metabolic genes; improves...

A β1 adrenergic receptor antagonist and a β2 adrenergic receptor partial agonist that relaxes human arteries and veins with ED₅₀ values of 40-50 µM in vitro; reduces myocardial infarct size and increases NO production in a rabbit model of myocardial ischemia at 1-10...

A natural macrocyclic peptide which potently inhibits the proliferation of PC3 prostate carcinoma cells (IC50 = 35 nM) by binding F-actin (KD = 15 nM); stabilizes actin filaments in vitro but disrupts actin filaments and induces irregular polymerization of monomeric actin in vivo.

Inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk7/cyclin H with IC₅₀ values of 8, 8, 5, and 10 nM, respectively; cytotoxic to human ovarian A2780, colon HCT116, pancreatic BX-PC3, and leukemic K562, KU812, KCL22, and TOM1 cells both in vitro and in xenograft models.

A peptide distributed throughout the central and peripheral nervous system that plays a major role in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion.

The opposite enantiomer of corey PG-lactone diol, a versatile, chiral intermediate used in the preparation of PGs and PG analogs.

A thiopeptide antibiotic effective against many different methicillin-resistant S. aureus strains (MICs ≤ 0.25 mg/L), Enterococcus spp (MICs ≤ 0.125 mg/L), and the BI strain of C. difficile (MIC = 0.008 mg/L) but inactive against most Gram-negative bacteria.

Potent, selective and non-competitive NMDA receptor antagonist (Ki = 30.5 nM); acts at the NMDA receptor-operated ion channel as an open channel blocker, preventing Ca2+ flux.

A natural tetracyclic diterpene with antiviral activity against herpes simplex; a cell-permeable, reversible inhibitor of DNA replication in eukaryotic cells, specifically blocking the activity of DNA polymerases α, δ, and ε when used at low micromolar levels.

A NO donor with a half-life of 2 minutes at 37°C, pH 7.4; liberates 1.5 moles of NO per mole of parent compound.