Cayman Chemical

A first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50s = 5.2 and 82 nM, respectively).

A negatively-charged, membrane impermeant MTS; highly reactive with ionized thiolates but not with unionized thiols and, therefore, targets sulfhydryl groups accessible from the aqueous medium; used to probe the structural and functional properties of membrane-associated proteins.

The first identified small molecule inhibitor of BLM helicase (IC₅₀ = 1.8 μM) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC₅₀s ≥ 50 μM); 25-50 μM dose-dependently inhibits the proliferation of BLM-expressing PSNF5...

An orally active, antiviral compound that induces interferon production and is reported to have antitumor, anti-inflammatory, and neuroprotective actions.

A selective TRPA1 blocker, antagonizing TRPA1-mediated calcium influx induced by AITC and formalin (IC50 = 6.2 and 5.3 μM, respectively); does not block currents mediated by TRPV1, TRPV3, TRPV4 hERG, or NaV1.2 channels; can be used in cells or delivered to animals orally, by inhalation, or by...

A competitive transition-state substrate analog inhibitor of DPP IV (Ki = 126 nM); used to improve glucose tolerance, insulin sensitivity, and β-cell glucose responsiveness in diabetic rat models at 20 mg/kg/day.

PGE1 is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology. COX metabolism of the unusual fatty acid 10,13,16-docosatrienoic acid yields 1a,1b-dihomo PGE1....

An imidazole that has potent antibacterial properties in drug-resistant bacteria; in bacteria, inhibits several histidine kinases, inhibiting YycG with IC50 values ranging from 0.7-4.7 µM; decreases viability of several cancer cell lines with IC50 values ranging from 0.7-4.7 µM.

A 14-carbon saturated (14:0) fatty acid.

A fatty acid amide from T. titanicus that at 0.1 μg/ml protects against ER stress-dependent cell death in Neuro2a cells induced by tunicamycin.

Inhibits GSK3β more potently (IC₅₀ = 18 nM) than CDK1/cyclin B or CDK5/p25 (IC₅₀s = 2.0 and 4.2 µM, respectively); stimulates the proliferation of human islets and drives the differentiation of mouse embryonic stem cells and Nematostella larvae.

PGE3 is formed via the COX metabolism of EPA. In human ocular tissue, it comprises 2.4% of the COX products formed. When applied to the eyes of a rabbit, a 1 µg dose of PGE3 decreases IOP from 21 mmHg to about 17 mmHg.

An internal standard for the quantification of linoleic acid by GC- or LC-MS.

An analytical reference standard categorized as an intermediate in the phytocannabinoid biosynthetic pathway; a precursor in the synthesis of CBDV, CBGV, and CBV; intended for research and forensic applications

A potent, reversible inhibitor of ceramide kinase (IC₅₀ = 12 nM), which has minimal effect on several other lipid kinases, including sphingosine kinases 1 and 2.

A C34:6 VLCPUFA whose specific biological actions are largely unknown.

A potent, reversible inhibitor of HDAC (IC₅₀ = 70 mM).

A derivative of thiouracil which has long been used to correct hyperthyroidism; also used as a genetic marker for taste, since only some people detect it as a bitter taste.

A single enantiomer of a potent and selective inactivator of KIAA1363, a MAGE hydrolase an enzyme that is upregulated in addressive cancers from various tissues (IC₅₀ = 150 nM when tested as a racemic mixture in SK0V-3 cells); activity of the individual enantiomers of AS 115, i.e. (+)-AS...

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in eosinophils, mast cells, and macrophages. Their biosynthesis proceeds via the 5-lipoxygenase (5-LO) pathway in which 5-LO converts arachidonic acid into LTA4 with 5(S)-HpETE as an intermediate. The...

An antibiotic that competitively inhibits the prokaryotic tryptophanyl-tRNA ligase (IC₅₀ = 30 μM); exhibits antibacterial activity against mupirocin- and fusidic acid-resistant strains of Staphylococci.

3-HPA is an analog of AM404, which is a selective inhibitor of carrier-mediated transport of AEA. 3-HPA is metabolized by both COX-1 and COX-2 and also selectively and irreversibly inhibits COX-2 with an IC50 value of 2 µM.

A slow, tight-binding inhibitor of class I HDACs, progressively binding HDACs and remaining bound after wash-out; inhibits class I HDACs (IC₅₀ = 150, 760, 370, and 5,000 nM for HDAC1, 2, 3, and 8, respectively) but not class II HDACs (IC₅₀ > 180 µM for HDAC4, 5, and...

Prostaglandin I (Prostaglandin I2; PGI2) is a potent vasodilator and inhibitor of platelet aggregation that is formed from arachidonic acid primarily in the vascular endothelium and renal cortex by sequential activities of cyclooxygenase (COX) and PGI2 synthase. It is non-enzymatically hydrated to...