Cayman Chemical

Triton™ X-100 (20% v/v) stock solution contains 20% Triton™ X-100. It is ready to use as supplied.

The biological effects of PGD2 are transduced by at least two 7-transmembrane G-protein coupled receptors, designated DP1 and CRTH2/DP2. BAY-u3405 (Ramatroban) is an approved human medication for the treatment of allergic rhinitis that has documented activity as an antagonist of both the TP and...

PGBx is a mixture of oligomers of PGB1 with a molecular weight of 1,000-1,500. It has antioxidant and free radical trapping activity that was first studied in isolated mitochondria.{477} PGBx has anti-inflammatory and cytoprotective activity which may be attributed to inhibition of the 14 kDa sPLA2....

A potent inhibitor of ROCK-II, PRK-2, MSK1, and MAPKAP-K1b with IC50 values of 1.9, 4, 5, and 15 µM, respectively; has been shown to reduce blood vessel constriction, decreases pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in a diabetic rat model; drug...

This bottle contains filtered HEPES (1 M), pH 7.5. The buffering range for HEPES is pH 6.8-8.2 and can be adjusted with KOH or NaOH. It is ready to use as supplied.

A selective agonist of GPR109B (HCA3; EC₅₀ = 400 nM) that displays no activity at GPR109A (HCA2).

A potent inhibitor of endothelial lipase (IC₅₀ = 16 nM).

Cayman’s Phagocytosis Assay Kit (IgG FITC) employs latex beads coated with fluorescently-labeled rabbit IgG as a probe for the measurement of the phagocytic process in vitro. The engulfed fluorescent beads can be detected using a fluorescence microscope, allowing kinetic studies of...

Source: Recombinant N-terminal His-tagged protein expressed in Sf21 cells Mr: 53.5 kDa EED is a WD40 repeat-containing protein that forms part of the Polycomb repressive complex 2 (PRC2). The EED subunit does not contain methyltransferase activity. However, transcriptional repression by...

A competitive NOS inhibitor; more potent inhibitor of nNOS (Ki = 3.0 µM) than eNOS (Ki = 10.0 µM) or iNOS (Ki = 9.5 µM).

Antigen: human CB2 receptor amino acids 20-33 Host: rabbit Cross Reactivity: (+) human and mouse CB2 receptor Application(s): FC, IF, and WB This antibody has been raised against a sequence between the N-terminal and the first transmembrane domain of the protein of the human CB2 receptor, a GPCR...

At 0.1-10 µM, .delta.-tocotrienol significantly suppresses H2O2-induced cell death of rat striatal neurons and provides protection against S-nitrocysteine-induced cell death and SIN-1 cytotoxicity in a concentration dependant manner. At concentrations of 10 µM, .delta.-tocotrienol...

A pyrrolopyrimidine that selectively blocks the activity of two forms of Lck kinase, Lck (64-509) and Lckcd, with IC₅₀ values of stimulated IL-2 production in mice (ED₅₀s = 4 and 25 mg/kg when administered either i.p. or orally).

A natural form of vitamin A that is thermally more stable than retinol; can reduce cell proliferation and promote differentiation.

An orally active inhibitor of PDE4 with an IC₅₀ value of 74 nM when tested in U937 cell lysates with 1 mM cAMP; decreases epidermal thickness in a mouse model of psoriasis, reduces both TNF-α and MMP-3 production in gut cells from patients with IBD, and improves clinical score in...

A covalent inhibitor of ABHD16A (IC₅₀s = 90 and 520 nM for human and mouse, respectively); depletes lyso-PS from various human cancer cell lines, a lymphoblast cell line, and mouse brain membrane lysates and decreases LPS-induced cytokine production in macrophages.

A substrate for the synthesis of RNA during the transcription process and the synthesis of DNA during DNA replication; participates in G-protein-related signal transduction where it is converted to GDP through the action of GTPases.

NVP-TAE226 is an inhibitor of focal adhesion kinase (FAK; IC₅₀ = 5.5 nM) and the related proline-rich tyrosine kinase 2-β (PYK2β; IC₅₀ = 5 nM). It can also inhibit the insulin-like growth factor 1 receptor (IC₅₀ = 0.16 µM) as well as the activity of...

An inhibitor of human reticulocyte 15-LO-1 (IC₅₀ = 200 nM) with >250-fold selectivity over the related enzymes 5-LO, platelet 12-LO, 15-LO-2, ovine COX-1, and human COX-2; protects against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduces infarct size...

A butyrophenone derivative which is used in the treatment of schizophrenia and delirium; binds to the dopamine D2 receptor (Ki = 0.1 nM), antagonizing dopamine signaling.

A potent inhibitor of TGF-βRI kinase (EC₅₀ = 48 nM) that has minimal or no effect at a variety of other kinases; blocks both autocrine and paracrine TGF-β signaling in glioma cells; is orally bioavailable and prevents TGF-β-induced Smad phosphorylation in spleens and brains...

A macrocyclic peptide antibiotic that prevents the growth of Gram-positive bacteria without affecting that of Gram-negative bacteria.

4-Aminomethylindole is a synthetic intermediate useful for pharmaceutical synthesis.

An internal standard for the quantification of PGF2α by GC- or LC-MS.