Cayman Chemical

This goat anti-rabbit IgG FITC is used as the 'secondary antibody' for immunofluorescent staining on tissues or culture cells where the primary antibody was generated in rabbits. It is highly recommended that proper negative controls, such as omitting the primary antibody, be included in...

A cell permeable derivative of GSH that undergoes hydrolysis by intracellular esterases to release GSH; used to protect cells against damage from radiation, oxidants, and various toxic compounds including heavy metals.

Triton™ X-100 (20% v/v) stock solution contains 20% Triton™ X-100. It is ready to use as supplied.

The biological effects of PGD2 are transduced by at least two 7-transmembrane G-protein coupled receptors, designated DP1 and CRTH2/DP2. BAY-u3405 (Ramatroban) is an approved human medication for the treatment of allergic rhinitis that has documented activity as an antagonist of both the TP and...

PGBx is a mixture of oligomers of PGB1 with a molecular weight of 1,000-1,500. It has antioxidant and free radical trapping activity that was first studied in isolated mitochondria.{477} PGBx has anti-inflammatory and cytoprotective activity which may be attributed to inhibition of the 14 kDa sPLA2....

A potent inhibitor of ROCK-II, PRK-2, MSK1, and MAPKAP-K1b with IC50 values of 1.9, 4, 5, and 15 µM, respectively; has been shown to reduce blood vessel constriction, decreases pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in a diabetic rat model; drug...

This bottle contains filtered HEPES (1 M), pH 7.5. The buffering range for HEPES is pH 6.8-8.2 and can be adjusted with KOH or NaOH. It is ready to use as supplied.

A selective agonist of GPR109B (HCA3; EC₅₀ = 400 nM) that displays no activity at GPR109A (HCA2).

A potent inhibitor of endothelial lipase (IC₅₀ = 16 nM).

Cayman’s Phagocytosis Assay Kit (IgG FITC) employs latex beads coated with fluorescently-labeled rabbit IgG as a probe for the measurement of the phagocytic process in vitro. The engulfed fluorescent beads can be detected using a fluorescence microscope, allowing kinetic studies of...

Source: Recombinant N-terminal His-tagged protein expressed in Sf21 cells Mr: 53.5 kDa EED is a WD40 repeat-containing protein that forms part of the Polycomb repressive complex 2 (PRC2). The EED subunit does not contain methyltransferase activity. However, transcriptional repression by...

A competitive NOS inhibitor; more potent inhibitor of nNOS (Ki = 3.0 µM) than eNOS (Ki = 10.0 µM) or iNOS (Ki = 9.5 µM).

Antigen: human CB2 receptor amino acids 20-33 Host: rabbit Cross Reactivity: (+) human and mouse CB2 receptor Application(s): FC, IF, and WB This antibody has been raised against a sequence between the N-terminal and the first transmembrane domain of the protein of the human CB2 receptor, a GPCR...

At 0.1-10 µM, .delta.-tocotrienol significantly suppresses H2O2-induced cell death of rat striatal neurons and provides protection against S-nitrocysteine-induced cell death and SIN-1 cytotoxicity in a concentration dependant manner. At concentrations of 10 µM, .delta.-tocotrienol...

A pyrrolopyrimidine that selectively blocks the activity of two forms of Lck kinase, Lck (64-509) and Lckcd, with IC₅₀ values of stimulated IL-2 production in mice (ED₅₀s = 4 and 25 mg/kg when administered either i.p. or orally).

A natural form of vitamin A that is thermally more stable than retinol; can reduce cell proliferation and promote differentiation.

An orally active inhibitor of PDE4 with an IC₅₀ value of 74 nM when tested in U937 cell lysates with 1 mM cAMP; decreases epidermal thickness in a mouse model of psoriasis, reduces both TNF-α and MMP-3 production in gut cells from patients with IBD, and improves clinical score in...

A covalent inhibitor of ABHD16A (IC₅₀s = 90 and 520 nM for human and mouse, respectively); depletes lyso-PS from various human cancer cell lines, a lymphoblast cell line, and mouse brain membrane lysates and decreases LPS-induced cytokine production in macrophages.

A substrate for the synthesis of RNA during the transcription process and the synthesis of DNA during DNA replication; participates in G-protein-related signal transduction where it is converted to GDP through the action of GTPases.

NVP-TAE226 is an inhibitor of focal adhesion kinase (FAK; IC₅₀ = 5.5 nM) and the related proline-rich tyrosine kinase 2-β (PYK2β; IC₅₀ = 5 nM). It can also inhibit the insulin-like growth factor 1 receptor (IC₅₀ = 0.16 µM) as well as the activity of...

An inhibitor of human reticulocyte 15-LO-1 (IC₅₀ = 200 nM) with >250-fold selectivity over the related enzymes 5-LO, platelet 12-LO, 15-LO-2, ovine COX-1, and human COX-2; protects against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduces infarct size...

A butyrophenone derivative which is used in the treatment of schizophrenia and delirium; binds to the dopamine D2 receptor (Ki = 0.1 nM), antagonizing dopamine signaling.

A potent inhibitor of TGF-βRI kinase (EC₅₀ = 48 nM) that has minimal or no effect at a variety of other kinases; blocks both autocrine and paracrine TGF-β signaling in glioma cells; is orally bioavailable and prevents TGF-β-induced Smad phosphorylation in spleens and brains...

A macrocyclic peptide antibiotic that prevents the growth of Gram-positive bacteria without affecting that of Gram-negative bacteria.