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A calcium-dependent activator of BKCa channels that is typically used at a concentration of 30 µM to hyperpolarize the membrane potential of single myocytes during studies of smooth muscle relaxation and vasodilation; cardioprotective against pulmonary hypertension as well as ischemia and...
A homolog of DHEA, characterized by the addition of an (S)-α-methyl group at the methylene carbon adjacent to the amide nitrogen.
A reduced form of coenzyme Q10 with antioxidant capability.
Peptide Sequence: human C-terminal amino acids 420-441 (TNINTTNQHIMLQNSSGIEKYN) To be used in conjunction with Cayman’s PAF-AH polyclonal antiserum (Catalog No. 160603) to block protein-antibody complex formation during analysis for PAF-AH.
A synthetic peptide recognized as a substrate by CaMKII (Km = 12 µM) as well as protein kinase C, CaMKV, Raf-1, and other kinases.
A potent, selective inhibitor of the lysine methyltranferase EZH2 (Ki = 24 nM), the enzymatic subunit of PRC2; blocks trimethylation of the PRC2 target H3K27 (IC50 = 80 nM), decreasing the proliferation of lymphoma cells carrying mutant, but not wild-type, EZH2.
A synthetic intermediate useful for pharmaceutical synthesis.
A potent, orally bioavailable inhibitor of γ-secretase that more potently inhibits the cleavage of APP to Aβ40 than signaling through Notch (IC50s = 0.30 and 58 nM, respectively); shows good pharmacokinetics in rats, dogs, and humans and passes the blood-brain barrier, reducing...
A potent inhibitor of PARPs, inhibiting PARP1 with an IC50 value of 40 nM; about 10-fold less potent against PARP2.
A metabolite of lipoxygenase-mediated oxidation of DPA; activates Nrf2-dependent antioxidant gene expression, acts as a PPARγ agonist (EC50 = ~200 nM), and inhibits pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 µM).
An acid degradation product produced by hydrolysis of the disaccharide unit of ivermectin; inhibits nematode larval development.
A specific cGMP-dependent PKG inhibitor (Ki = 86 µM); a nonphosphorylatable synthetic peptide analogous to a substrate corresponding to the serine-32 phosphorylation site in histone H2B.
A prenylated 4-hydroxycoumarin with potent activity against mycobacteria; stimulates tubulin polymerization and is cytotoxic to various human tumor cell lines; disrupts oxidative phosphorylation, inhibiting succinate ubiquinone reductase.
Sodium Phosphate Stock Solution (500 mM, pH 9.0) contains filtered 500 mM sodium phosphate buffer. It is ready to use as supplied.
An orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM); over 1,000-fold less active at other prostanoid receptors, including other EP receptors.
A benzazepine derivative that antagonizes the binding of AVP to vasopressin V2 receptors (IC50 = 14 nM); inhibits the antidiuretic action of AVP, promoting aquaresis when administered intravenously to rats at 10-100 µg/kg.
A chromogenic cephalosporin substrate commonly used to detect β-lactamases in bacteria and other microbes.
A potent flavanoid inhibitor of soybean and reticulocyte 15-LOs (IC50 = 0.6 µM)
A potent inhibitor of the tyrosine kinases JAK2, FLT3, RET, and JAK3 (IC50 = 6, 25, 17, and 169 nM, respectively); induces cell cycle arrest and apoptosis in leukemic cell lines and CD45+ myeloma cells.
Blocks and reverses platelet aggregation induced by such triggers as collagen, U-46619, and ADP (IC50 = 1.1, 2.1, and 4.1 µM, respectively); reduces tyrosine phosphorylation in stimulated platelets and inhibits recombinant human Syk and Src (IC50 = 2.8 and 27.3 µM,...
An orally bioavailable, blood-brain barrier permeable complex used in cellular imaging experiments to selectively label hypoxic tissue; improves locomotor function and survival in a transgenic ALS mouse model by delivering copper specifically to cells in the spinal cords of mice to prevent...
A red-colored carotenoid found in tomatoes and other red fruits and vegetables; powerful antioxidant that efficiently quenches singlet oxygen.
A lysosomal condensation product that selectively eliminates dipeptidyl peptidase I-expressing immune cells, including cytotoxic T cells and natural killer cells.
The amide of the neurotransmitter dopamine and arachidonic acid; a CB1-selective agonist that induces hypothermia, analgesia, catalepsy, and hypomotility in rats; a full agonist at TRPV1, but inactive at the dopaminergic D1 and D2 receptors; a potent inhibitor (IC50 = 0.25 µM) of...