Cayman Chemical

A sesquiterpene dialdehyde noted for its broad antifungal properties; cytotoxic against bacteria, algae, and sea squirts; in mammals, produces a pungent flavor, activates TRPA1 (EC₅₀ = 59 nM), and produces antinociception.

An activator of the GTP-binding protein Rab7 (EC₅₀ = 77.6 nM) that demonstrates selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC₅₀s = 588.8, 346.7, 158.5, and 794.3 nM, respectively).

A potent blocker of HCN channels that inhibits HCN4 more potently than HCN1 (IC₅₀s = 32 and 158 nM, respectively); modulates the sinoatrial node and slows heart rate; reduces neuropathic pain in several animal models.

A potent pan inhibitor of class I catalytic subunits of PI3K, inhibiting p110α, β, δ, and γ with IC50 values of 3, 33, 3, and 75 nM, respectively; inhibits the growth of certain types of cancer cells, and blocks signaling through PI3K to Akt, both in cells and in vivo.

A potent, reversible inhibitor of AMPK (Ki = 109 nM); dose-dependently inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6); downregulates the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.

Antigen: fusion protein containing amino acids 1-564 of the NR1 subunit of rat NMDA receptor Host: mouse Cross Reactivity: (+) rat and mouse NMDA receptor Application(s): IP and WB The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders...

A potent, reversible, and selective inhibitor of ALDH1A1 (IC₅₀ = 40 nM for the human form).

An optically active isomer of TBP-OH, a compound produced from the metabolism of the organophosphorus solvent, TBP.

A naturally occurring metabolite of bile acid that is produced by the conjugation of cholic acid and sulfate, predominantly in the liver and gut.

A partial agonist of PPARγ; activates PPARγ with a lower potency (Ki = 15 versus 0.035 µM) but a similar maximal efficacy compared to rosiglitazone; improves insulin resistance in normal, diet-induced glucose-intolerant, and in diabetic db/db mice, yet reduced adipogenic activity.

Source: Active recombinant C-terminal His-tagged protein expressed in E. coli MW: 47.9 kDa

A membrane-impermeant lidocaine derivative that when combined with capsaicin selectively blocks sodium channels on nociceptive neurons via the TRPV1 channel; decreases the pain response without imparting numbness or paralysis associated with other local anesthetics.

A NO donor with a half-life of three hours at 37°C, pH 7.4; liberates two moles of NO per mole of parent compound.

The primary metabolite of the tricyclic antidepressant doxepin.

1-Oleoyl lysophosphatidic acid is a species of LPA containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of PLD or through a two step process involving liberation of DAG by PLC followed by phosphorylation of DAG by diglycerol kinase.{2656}...

Glycogen is the principal storage form of glucose in animal and human cells. It is made primarily by the liver and muscles, but it can also be made by glycogenesis within the brain and stomach. Cayman’s Glycogen Assay provides a simple, reproducible, and sensitive tool for assaying glycogen...

Antigen: SDS-denatured rat tyrosine hydroxylase, purified from pheochromocytoma Host: rabbit Cross-Reactivity: (+) mammalian tyrosine hydroxylase Application: IF, IHC, and WB

Immunogen: Synthetic peptide from an internal region of human protein cPGES Host: Rabbit Species Reactivity: (+) Human, mouse, and ovine cPGES Cross Reactivity: (−) human mPGES Application: WB

A potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.3 nM).

DPP (IV) inhibitors have emerged as a new class of oral antidiabetic agents. These inhibitors promote glucose homeostasis by inhibiting degradation of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) by DPP (IV). GLP-1 extends the action of insulin while...

A bioactive lignan component of P. amarus with antioxidative and hepatoprotective properties; scavenges DPPH radicals (IC50 = 7.4 µM) and alleviates carbon tetrachloride-induced lipid peroxidation and cytotoxicity in a human hepatoma HepG2 cell line.

A selective EGFR-TK inhibitor that blocks the growth of GEO colon cancer, ZR-75-1 and MCF-10A Ha-ras breast cancer, and OVCAR-3 ovarian cancer cell lines (IC₅₀s = 0.2-0.4 µM); interferes with the intracellular kinase domain of the EGFR; used to treat advanced (or recurrent)...

A stable derivative of (±)4(5)-EpDPA, a CYP450 metabolite of DHA which can be further metabolized to the diol metabolite; the active free acid can be regenerated from the methyl ester by careful base hydrolysis.

An inhibitor of β-catenin/Tcf-mediated transcription and an antagonist of ligand-dependent activation of PPARγ and PPARδ; blocks the recruitment of β-catenin and GRIP1 to PPARγ and PPARδ; selectively toxic to some carcinoma cell lines expressing the...