Cayman Chemical

An analog of AA with the triple bond in the 5,6 position; inhibitor of 5-LO (Ki = 10-15 μM).

A cephalosporin antibiotic that is active in vitro against most Gram-positive and Gram-negative bacteria, including β-lactamase strains (3-4 µg/ml inhibits 90% of S. aureus growth).

An inhibitor of EGF receptor kinase with an IC50 value of 2.4 µM in the human epidermoid carcinoma cell line A431.

C-8 ceramine is an analog of C-8 ceramide in which the carbonyl group of the ceramide is replaced by a methylene group. At a concentration of 10 µM, C-8 ceramine induces maximal DNA fragmentation in U937 cells after 6 hours of incubation, compared to 12 hours for C-8 ceramide.

An endogenous CB neurotransmitter that binds to both CB1 and CB2 receptors.

A selective inhibitor of RIP2 kinase (IC₅₀ = 5 nM), a central component of the innate immune system.

The dominant alkaloid found in tobacco plants that acts as an agonist at neuronal nicotinic acetylcholine receptors (nAChRs; Kis = 481 and 11.1 nM for α3β4 and α4β2 subtypes, respectively).

20-HETE-d6 contains six deuterium atoms at the 16, 16', 17, 17', 18 and 18' positions. It is intended for use as an internal standard for the quantification of 20-HETE by GC- or LC-mass spectrometry.

An inhibitor of BRD4 (Kd = 550 nM; IC₅₀ = 637 nM), TAF1 (Kd = 560 nM), and TAF1L (Kd = 1.3 µM).

LY2409881 is a selective inhibitor of IκB kinase β (IKK2; IC₅₀ = 30 nM). It inhibits IKK1 and other common kinases at ≥10-fold higher concentrations. LY2409881 has been shown to suppress constitutively activated NF-κB and to induce apoptosis in lymphoma cells both in...

A product of 5-LO catalyzed oxidation of arachidonic acid.

A selective inhibitor of the E2 ubiquitin-conjugating enzyme Ubc13 when heterodimerized with Uev1A, blocking polyubiquitin chain formation at concentrations of 0.5 to 2 µM in vitro; blocks proliferation and induces apoptosis in DLBCL and NB cells.

A cell-permeable inhibitor of Hhat (IC₅₀ = 0.85 µM); blocks palmitoylation of Shh without affecting palmitoylation of H-Ras or Fyn, myristoylation of c-Src, or acylation of Wnt3a; inhibits both autocrine and paracrine Shh-induced activation of Gli-mediated transcription.

A dual inhibitor of both NOX1 and NOX4 with Ki values in the range of 100 to 150 nM in cell-free assays of ROS production; displays good oral bioavailability with high plasma concentrations in vivo and attenuates liver fibrosis in mice.

A ceramide analog that inhibits glucosylceramide synthase with an IC₅₀ value between 2 and 20 µM.

A potent QseC inhibitor that blocks both norepinephrine- and epinephrine-triggered QseC-dependent virulence gene expression at 5 pM in vitro.

A dual inhibitor of IGF1R kinase and IR (IC₅₀s = 100 and 73 nM, respectively); blocks IFG1R autophosphorylation and signaling through MEK1/2 and Akt, leading to G1 arrest and apoptosis in ML-1 cells; reverses EMT in MCF10A cells overexpressing constitutively activated IGF1R.

A component of certain essential oils used in traditional Chinese herbal medicine; carcinogenic, neuroprotective, and radioprotective in mice when given at 50 mg/kg; inhibits HMG-CoA reductase (IC50 = 3 mM); inhibits CYP2D6 and CYP3A4 (IC50 = 55.2 and 65.2 μg/ml, respectively).

A selective inhibitor of the breast cancer resistance protein ABCG2 (IC₅₀ = 0.23 µM).

The PGF2α Quant-PAK has been designed for the convenient, precise quantification of PGF2α by GC- or LC-MS. It includes a 50 µg vial of PGF2α-d4 and a precisely weighed vial of unlabeled PGF2α, with the precise weight (2-4 mg) indicated on the vial. This unlabeled...

A selective inhibitor of CBP and EP300 which directly binds their bromodomains (Kds = 0.142 and 0.625 μM); shows only weak cross reactivity with the bromodomains of BET proteins and shows no interaction with other bromodomains.

A glucose analog that potently inhibits α-glucosidase I and II to prevent the formation of complex N-linked oligosaccharides (IC50= ~2 µM).

Antigen: synthetic peptide from human HDAC7 containing phospho-Ser155 Host: rabbit Cross Reactivity: (+) chimpanzee, bovine, canine, human, monkey, mouse, and rat HDAC7 Application(s): WB HDAC7 is a class IIa HDAC that plays a specific role in maintaining vascular integrity by repressing the...

A selective inhibitor of the Na+/Ca2+ exchanger (IC₅₀s = 5, 8.3, and 33 nM for inhibiting Na+-dependent Ca2+ uptake in rat astrocyte, microglia, and cortical neuron cell lines, respectively).