Cayman Chemical

A chromogenic substrate for N-acetyl-D-galactosaminidase that generates a yellow solution upon cleavage.

A tricyclic antidepressant that blocks norepinephrine and serotonin transporters (KDs = 4.4 and 18 nM, respectively) more potently than the dopamine transporter (KD = 1.1 µM).

A selective inhibitor of late INa that has been shown to suppress experimentally induced arrhythmias in rabbit myocytes and hearts; inhibits A. sulcata toxin II–induced late INa in ventricular myocytes and isolated hearts (IC₅₀s = 0.13 and 0.21 µM, respectively).

An Hh signaling pathway inhibitor that acts by antagonizing SMO (IC₅₀s = 1.3 and 2.5 nM for mouse and human, respectively); inhibits Gli1 mRNA expression and prevents tumor growth in a medulloblastoma allograft mouse model at 20 mg/kg/day.

A benzimidazole analog that inhibits IKK-ε with an IC50 value of ~15.8 µM.

A cell permeable phenoxazine derivative that suppresses IGF-1-stimulated phosphorylation of Akt with an IC₅₀ value of 1-2 μM; inhibits the growth of Rh1, Rh18, and Rh30 cells with IC₅₀ values of 2-5 μM.

A tyrosine kinase inhibitor which acts on EGFR, inhibiting EGFR-associated kinase activity (IC50 = 2.5 µM) and tumor growth in human HN5 tumor xenografts in mice with an ED50 value of 9 mg/kg; drug form of Erlotinib, Tarceva™, is used to treat certain forms of cancer.

An analytical reference standard categorized as a phytocannabinoid; intended for research and forensic applications,

For the induction of a respiratory burst response in neutrophils and monocytes, and quantification by flow cytometry. Samples include whole blood from any species or cells of any type that are capable of producing a NADPH oxidase-dependent respiratory burst Induce and quantify a respiratory burst...

16,16-dimethyl PGF2α is a metabolically stable analog of PGF2α. It binds to the FP receptor on ovine luteal cells with slightly better affinity (159%) than PGF2α.

An internal standard for the quantification of RvD2 by GC- or LC-MS.

A broad-spectrum tetracycline antibiotic which has a particularly long half-life in serum; commonly used in the treatment of acne in older patients; also has both anti-inflammatory and neuroprotective actions.

A simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine that was prepared as a mechanism for enhancing CNS dopamine content by facilitated transport of the tyrosine precursor across the blood-brain barrier; increased CNS dopamine...

An epimer of (−)-EGC and potent antioxidant; significantly inhibits the proliferation of HCT116 and SW-480 cancer cells; inhibits the aggregation of amyloid β peptide in vitro (IC₅₀ = 17.5 µM).

Molecular Formula: C₂₄H₂₈D₁₃N₇O₅ Formula Weight: 640.8

A synthetic intermediate useful for pharmaceutical synthesis.

An antibiotic that can inhibit cell wall synthesis in plant-pathogenic oomycetes (MIC = 25 µg/ml for P. medicaginis M2913) and certain fungi as well as some bacterial species (MIC = 400 µg/ml for S. aureus).

A synthetic intermediate for pharmaceutical synthesis.

A dual inhibitor of the two mammalian forms of PLD, PLD1 and PLD2 (IC₅₀s = 6 and 20 nM, respectively); penetrates the CNS and is functional in vivo when given intraperitoneally; has potential applications in oncology and virology.

Stabilizes HIF from degradation in the proteasome and increases endogenous production of erythropoietin by inhibiting HIF-1α prolyl hydroxylase (IC₅₀ = 0.49 µM); investigated in clinical trial for treatment of patients with anemia associated with chronic kidney disease and/or...

An irreversible inhibitor of TPPII commonly used at 10-100 µM; does not significantly interfere with the chymotrypsin-like activity of the proteasome; also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 µM.

A FFAR1 (GPR40) antagonist that inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid with IC₅₀ values of 6.28, 5.96, 7.07, and 4.58 µM, respectively; inhibits glucose-stimulated insulin secretion, reduces blood insulin levels, improves...

A calcium sensitizer that causes increased cardiac contractility by binding troponin C (EC₅₀ = 9 nM), promotes vasodilation by activating ATP-sensitive potassium channels on vascular smooth muscle cells (EC₅₀ = 0.28 µM), and performs a cardioprotective function by...

Antibody: Streptavidin Dye: Europium Chelate W-1024 Excitation max. λ: 340 nm Emission max. λ: 615 nm Uses: TR-FRET high throughput screening (HTS) applications (LANCE®, HTRF®)