Cayman Chemical

An analog of PGF2α in which the ω-chain has been extended by the addition of two more methylene carbon atoms; exhibits a Ki value of 120 nM for the FP receptor.

A naturally-occurring amino acid which is a stable antioxidant; scavenges free radicals and oxidants, controls NF-κB activation, and inhibits inflammatory gene expression; blocks oxidative DNA damage and cell death.

15(S)-15-methyl PGD2 is a metabolically stable synthetic analog of PGD2. In contrast to PGD2, 15(S)-15-methyl PGD2 induces vasoconstriction and increases systemic blood pressure with much reduced inhibitory activity on ADP-induced platelet aggregation. It also exhibits strong antifertility activity...

A proapoptoic compound with selectivity for cancer cells; induces apoptosis in vitro in various cancer cell lines (IC50 = 0.89-2.69 µM).

Naturally occuring mycotoxin and food contaminant that induces the transversion of G to T at codon 249 of the p53 tumor suppressor gene and is a likely pathogen that causes hepatocellular carcinoma.

Acts as a replacement for endogenously-produced farnesyl alcohol and becomes attached to proteins through normal biological processes, in cells or animals; the terminal azide group can be used to readily tag farnesylated proteins via click chemistry for subsequent analysis.

A long-chain acylcarnitine with both intracellular and extracellular roles; transported into mitochondria to deliver palmitate for fatty acid oxidation; alters calcium mobilization in many cell types; also affects endothelial and epithelial tight junctions, reducing resistance and increasing...

A peripheral dopamine D2 and D3 receptor antagonist (Ki = 0.3 nM; IC₅₀ = 13.6 nM for rat D2 and IC₅₀ = 2.68 nM for rat D3); antiemetic and upper gastrointestinal tract prokinetic activities have been evaluated in clinical trials.

Racemic version of a potential CYP450 metabolite of AEA.

A general calcium channel blocker that shows modest selectivity for T-type channels over L-type channels (IC₅₀ = 2.7 and 18.6 μM, respectively); a potent vasodilator, increasing coronary artery flow with an EC₅₀ value of 54 nM.

Isoprostanes are prostaglandin (PG)-like products of free-radical induced lipid peroxidation. Although the isoprostanes derived from arachidonic acid are the best characterized, many other polyunsaturated fatty acids can form isoprostanes. iPF2α-VI is one of dozens of possible stereo- and...

Antigen: synthetic peptide corresponding to amino acids 1-16 of human HDAC6 Host: rabbit Cross Reactivity: (+) human and mouse HDAC6 Application(s): WB, IP, and ChIP HDAC6 is a class II HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating...

An inhibitor of oxidosqualene cyclase (OSC) that has LDL cholesterol lowering activity; inhibits OSC from human liver microsomes and HepG2 cells with IC50 values of approximately 6.5 and 1.5 nM, respectively.

An analog of ceramide that inhibits alkaline ceramidase (IC50 ~5 µM); suppresses growth of HL-60 cancer cells in culture.

An inhibitor of ferroptosis (IC₅₀ = 60 nM), a specific type of non-apoptotic, iron-dependent, oxidative cell death; prevents ferroptosis in cancer cells and inhibits cell death in cell models of Huntington’s disease, periventricular leukomalacia, and kidney dysfunction.

A selective inhibitor of B-RafV600E mutant melanoma cell proliferation (EC₅₀ = 4 nM) with little activity against wild-type B-Raf or a panel of 100 other kinases (IC₅₀s = 900 nM); decreases phosphorylation of the B-Raf substrate MEK at oral doses of 6 mg/kg in human melanoma...

Pyruvate (pyruvic acid) is a key intermediate in cellular metabolic pathways and is derived primarily from glucose via glycolysis. Abnormal blood pyruvate levels are reported in a number of disorders including shock, liver disease, congestive heart failure, diabetes mellitus, thiamine deficiency,...

An inhibitor of SRPK1 (Ki = 0.89 µM); suppresses the propagation of viruses in mammalian cells; modulates alternative splicing of VEGF, reducing neovascularization both in cells and in animals.

Uric acid (urate) is the end product of human purine metabolism and is mainly excreted in urine. Many factors, including genetic components and acquired factors, such as obesity and alcohol consumption, influence serum uric acid concentrations. Hyperuricemia induces or facilitates gout, kidney...

A novel CYP450 metabolite of 2-AG in the kidney; acts as a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells at concentrations as low as 100 nM and doubling cell proliferation rates at 1 µM.

17-trans PGF3α is a double bond isomer of PGF3α and a potential metabolite of trans dietary fatty acids. There are no published reports on the biological activity of this compound.

A nitrogen mustard alkylating agent used in the treatment of cancers and autoimmune disorders; metabolized to the active compound phosphoramide mustard, which crosslinks with DNA and causes cell death.

Antigen: human CysLT2 receptor N-terminal amino acids 1-18 Host: rabbit Cross Reactivity: (+) human CysLT2 receptor; (−) CysLT1 receptor, mouse, and rat CysLT2 receptors Application(s): FC, ICC, IHC, and WB The CysLT2 receptor binds LTD4, LTC4, and LTE4 playing a major role in asthma by...

Inhibits actin polymerization; potently and selectively inhibits the growth of endothelial cells (IC50 1 protease activity.