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A 15-carbon, long-chain fatty acid that contains an alkene functional group on the terminal carbon of its aliphatic tail.
A dimeric spiroisoxazoline derived from marine sponges that inhibits proliferation of HeLa cells with an IC50 value of 29 µM.
A dual inhibitor of FAK and PYK2 (IC50s = 2 and 11 nM, respectively) that increases bone formation, promoting osteoblast recruitment and activity in ovariectomized rats.
Antigen: recombinant mouse ANGPTL3 Host: rat, clone Kairos3-3741 Cross Reactivity: (+) mouse ANGPTL3; (−) mouse ANGPTL4 and human ANGPTL3 Application(s): ELISA and WB ANGPTL3 regulates angiogenesis and also directly regulates lipid, glucose, and energy metabolism.
A minor metabolite found in human plasma after intravenous administration of sulprostone.
An internal standard for the quantification of TXB2 by GC- or LC-MS.
An internal standard for the quantification of metformin by GC- or LC-MS.
A potent, orally available inhibitor of JAK2 (IC50 = 1.3 nM); reduces the production of inflammatory cytokines and blocks disease development in mouse models of lupus and arthritis; induces regression of established colorectal tumors in mice, reducing angiogenesis and proliferation of...
Host: mouse, clone 143-13 Cross Reactivity: (+) human CD25; other species not tested Applications: (+) FC, ICC, and IHC (frozen sections); (−) WB
Cayman’s IL-1α (human) ELISA is an immunometric (i.e., sandwich) ELISA that permits IL-1α measurements within the range of 3.9-250 pg/ml, typically with a limit of detection of 3.9 pg/ml.
An ATP-competitive, multi-targeted RTK inhibitor that inhibits all members of the VEGF and PDGF receptor families (IC50s = 4-190 nM); inhibits proliferation in MV-4-11 and MOLM-13 cells (IC50s = 4 and 6 nM, respectively).
(±)14(15)-EET-d11 contains 11 deuterium atoms at the 16, 16', 17, 17', 18, 18' ,19, 19' ,20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)14(15)-EET (Item No. 50651) by GC- or LC-MS.
PGD2 methyl ester is a more lipid-soluble, cell-permeable prodrug form of PGD2. It binds to the human and mouse PGD2 receptors (DP1 and CRTH2/DP2) with 5-10 fold lower affinity than PGD2.
A form of DAG where both acyl groups consist of the 18:1 oleoyl chain; binds the C1 domain and activates conventional PKC forms and serves as a substrate for diacylglycero kinases and multisubstrate lipid kinase.
9(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation. 9(R)-HODE cholesteryl ester can be used as a standard for analysis...
A staurosporine analog that potently inhibits JAK2 kinase (IC50 = 1 nM) and downstream targets STAT5 (IC50 = 10-30 nM) and STAT3 in a human erythroleukemic cell line expressing the JAK2V617F mutation; potently inhibits the epigenetic kinase PRK1 (PKN1) in vitro (IC50...
A fluoroquinolone antibiotic used in animals, including dogs, cattle, and swine, to combat gastrointestinal and respiratory infections.
A highly sensitive, rhodamine phenylglyoxal-based fluorophore that specifically detects protein citrullination via a chemoselective reaction between glyoxal and citrulline; reacts with any citrulline-containing protein and can be analyzed with fluorescent imaging (Ex. 532 nm; Em. 580 nm); limit of...
Estrone is one of the three naturally occurring estrogens, the others being estradiol and estriol. Estrone is synthesized from androstenedione by the aromatase enzyme system in the ovaries and placenta, and is also synthesized from estradiol by 17-hydroxy steroid dehydrogenase in the liver. Serum...
An inhibitor of topoisomerase II (IC50 = 60.3 μM); can have much greater potencies when evaluated in cell-based cytotoxicity assays (e.g., IC50 = 5.14 nM for MCF-7 cells); can also inhibit nuclear receptor coactivator 3 (IC50 of 2.48 μM).
An antagonist of sweet taste receptors that blocks the activation of T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds; used to explore the roles of these receptors in diverse pathways.
A non-selective mACh receptor antagonist and non-specific inhibitor of voltage-gated ion channels in neurons; used to study animal models of vertigo and emesis.
Immunogen: mouse recombinant sEH Host: rabbit Species Reactivity: (+) human and mouse sEH Application(s): WB sEH metabolizes exogenous and endogenous epoxides into corresponding diols.
A cell-permeable inhibitor of sirtuin NAD+-dependent deacetylases, inhibiting the yeast sirtuin Sir2p with an IC50 value of 68 μM and the human sirtuins SIRT1 and SIRT2 with IC50 values of 131 and 38 μM, respectively; does not alter HDAC1 activity.