Cayman Chemical

A natural product which effectively kills both malarial parasites P. falciparum and P. vivax (IC50 = 1.8 nM); usually used in combination with lumefantrine for the treatment of malaria; also kills trematodes of the species Schistosoma; has potential applications in certain types of cancer.

A selective Ras inhibitor that blocks H-Ras GTP binding to c-Raf-1 (Ki = 149 µM); inhibits both anchorage-dependent and -independent growth and induces apoptosis of H-RasG12V-transformed NIH 3T3 cells (IC₅₀ = 1.4-2 µM).

An inhibitor of ALK with an IC₅₀ value of 200 pM in enzymatic assays; inhibits ALK in cells (IC₅₀ = 25 nM) and in vivo, producing tumor regression in a rat xenograft model.

A potent inhibitor of B-Raf (Kd = 0.3 nM) that less effectively inhibits c-Raf (Ki = 1.72 nM) and has little effect at 46 other kinases; blocks activation of ERK1/2 and anchorage-independent cell proliferation of melanoma cells with either wild type or V600E B-Raf at nanomolar concentrations.

Antigen: mixture of synthetic peptides corresponding to rat caspase-9 amino acids 345-359 and 366-383 Host: rabbit Cross Reactivity: (+) human, mouse, and rat caspase-9 Application(s): WB CTD is a novel isoform of rat caspase-9 in which the C-terminus of full-length caspase-9 is replaced with an...

A member of the 2-aryl propionic acid group of NSAIDs that reduces inflammation through inhibition of NF-κB and AP-1 activation; decreases survival of prostate tumor cells by inducing p75NTR protein expression; inhibits the enzyme γ-secretase thereby preventing the formation of the...

An organosulfur compound derived from allicin; converted, in the presence of thiols, to the gaseous mediator H2S; serves as a thiol-dependent H2S donor in biological systems.

An aspirin-triggered epimer of RvD1; reduces human leukocyte transendothelial migration (EC50 = ~30 nM), and limits leukocyte infiltration in a mouse model of peritonitis.

A kaempferol glycoside that selectively inhibits RSK2 with an IC50 value of 89 nM (Ki = 1 μM) without interfering with upstream activators of RSK, including ERK, MEK, EGFR, and PKC; inhibits the proliferation of MCF-7 breast cancer cells at 100 μM and attenuates angiotensin II-induced cell...

LTB4 is synthesized from arachidonic acid by the combined action of 5-LO and LTA4 hydrolase. LTB4 has long been recognized as a potent mediator of inflammation. It stimulates a number of leukocyte functions, including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release,...

An endogenous hydrophilic bile acid that interferes with the transport activity of the sodium taurocholate cotransporting polypeptide with an IC₅₀ value of 3.6 μM; also inhibits liver cell death by interrupting the classic pathways of apoptosis.

Didox is a simple, synthetic antioxidant that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients with dementia. It also increases the radiosensitivity of cancer cells by inhibition of ribonucleotide reductase, resulting in a reduction of bcl-2 mediated...

One of several novel taurine-conjugated fatty acids that act as a FAAH substrate and may activate TRPV1 and TRPV4.

GPR55 is a G protein-coupled receptor that has been identified as a novel cannabinoid receptor, although its exact role is still controversial. Previously central cannabinoid (CB₁) and peripheral cannabinoid (CB₂), two widely characterized receptors have been shown to bind THC...

A non-selective, low-trapping, voltage-dependent NMDA channel blocker (IC₅₀ = 4-7 µM) that binds to sites within the channel pore with a Ki value of 0.56-2.1 µM; used to produce antidepressant effects without adverse psychotomimetic activity.

4-(1-piperazinyl)-1H-Indole (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.

A selective inhibitor of iPLA2 that demonstrates an XI(50) value of 0.0073; in comparison, mole fractions as high as 0.091 do not inhibit cPLA2 activity and cause only slight inhibition of sPLA2.

A saturated N-acylethanolamide whose non-CB receptor-mediated pharmacology is still being elucidated; may have a role in the functioning of ion channels.

An inhibitor of ATR and ATM kinases (IC₅₀ = ~ 200 nM) that induces cell death in prematurely senescent breast, lung, and colon cancer cells.

A selective, cell-permeable PKC inhibitor that displays 10-fold greater selectivity for PKCα (IC50 = 9 nM) and 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over Ca2+-independent PKCε (IC50 = 108 nM); prevents T-cell activation and proliferation associated with chronic...

A fluorescent probe which stains dsRNA in living or fixed cells as well as in tissues; amenable to FC; maximum excitation is at 540-550 nm, with maximum emission at 560-580 nm.

An internal standard for the quantification of LTD4 by GC- or LC-MS.

A hybrid molecule patterned after arachidonoyl serotonin; the biological effects of eicosapentaenoyl serotonin are unknown.

A purine base that acts as a precursor, substrate, or cofactor in diverse biochemical pathways.