Cayman Chemical

CAS Number: 883986-34-3 Molecular Formula: C₂₄H₂₅N₅O₄ Formula Weight: 447.5

A selective EP4 receptor antagonist (Ki = 0.7 nM versus a Ki > 1 µM for other EP receptors) that has been shown to inhibit inflammation without gastrointestinal toxicity in various animal models for arthritis.

An agonist of both nAChR and mAChR receptors, with reported Ki values ranging from 10 to 10,000 nM for different receptors and different preparations; used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility, and neuronal signaling.

A benzothiadiazide that acts as a potentiator of AMPA receptors, positively modulating its response to glutamic acid (EC₅₀ = 3.8 µM); also a negative modulator of GABAA receptors, reversibly inhibiting both evoked and spontaneous inhibitory postsynaptic currents (IC₅₀ =...

A norepinephrine metabolite.

An orally bioavailable proteasome inhibitor; targets the chymotrypsin-like activity of the 20S proteasome subunits β5 and LMP7 (IC₅₀s = 36 and 82 nM, respectively); inhibits the growth of multiple myeloma cells at nanomolar concentrations.

CAY10502 is a potent inhibitor of cPLA2α with an IC50 value of 4.3 nM for the purified enzyme from human platelets. It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively.

Contains the intermediary and secondary metabolites of PGE2, PGD2, and PGF2α; designed for direct use in LC-MS applications.

An alkyne-tagged electrophile that can be used as a probe to isolate and identify the reaction products of lipid peroxidation using click chemistry.

A fluorescent dye for noninvasive measurement of changes in membrane voltage; excitation and emission maxima of ~467 and 631 nm, respectively, when incorporated into the lipid bilayer.

An inhibitor of EGFR kinase with an IC50 value of 3 nM.

Selective, noncompetitive inhibitor of the MAPK pathway; prevents the activation of MAPKK1 by Raf or MEK kinase with an IC50 value of 2-7 µM

A fluorogenic substrate that can be cleaved specifically by caspase-8.

Sesamin is a non-competitive inhibitor of .DELTA.5-desaturase. It inhibits the conversion of DGLA to arachidonic acid with a Ki value of 155 µM in rat liver microsomes.

A stilbene sulfonate that inhibits anionic transport.

A synthetic agonist for REV-ERBα (EC50 = 0.4 μM) that mimics the action of heme; at 10 μM inhibits the expression of the circadian target gene bmal1 and reduces glucose output by 30% in mouse primary hepatocytes by repressing the expression of several gluconeogenic genes.

A specific and potent inhibitor of MPC carrier activity; potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC₅₀ = 50 nM).

The predominant LO product of arachidonic acid formed in mammalian platelets; enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 µM.

A fluorescent DNA dye that is commonly used for the detection or exclusion of non-viable cells in flow cytometric analysis; exhibits minimal spectral overlap with and can be used with PE and FITC; can also be used to evaluate apoptosis and cell-mediated cytotoxicity, and to stain DNA in cells that...

An NSAID with analgesic and antipyretic actions; potently inhibits COX-1 (IC₅₀ = 30 nM).

A biscoclaurine alkaloid that can decrease the fluidity of biological membranes; exhibits antiparasitic, antimalarial, antiviral, anti-inflammatory, antimetastatic, and anticancer activities in various cell and animal models.

A synthetic intermediate useful for pharmaceutical synthesis.

A C-8 analog of methylcarbamyl PAF C-16, a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma; induces G1-phase cell cycle arrest, suggesting a potential role in the inhibition of oncogenic transformation.

A synthetic intermediate useful for pharmaceutical synthesis.