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An inhibitor of several different PTPs, with selectivity for PTEN (IC50 = 38 nM); also inhibits PTP-β (IC50 = 343 nM), PTP-1β (IC50 = 920 nM), and SHIP-2; activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation...
A natural mycotoxin that binds F-actin; contains a carboxyl group for coupling reactions.
An internal standard for the quantification of 4-HNE-GSH (trifluoroacetate salt) by GC- or LC-MS.
A phospholipid in which the two acyl substituents at positions sn-1 and sn-2 are specified as palmitoyl (16:0) and lauroyl (12:0), respectively.
A retinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC50 = 0.36 nM) compared to RARβ (Kd = 131 nM; AC50 = 24.6 nM) and RARγ (Kd = 450 nM; AC50 = 27.9 nM); used in combination with the GSK3β inhibitor CHIR99021 to induce differentiation of human induced...
Antigen: CHO cells transfected with human TLR2 cDNA Host: mouse, clone TL2.1 Cross Reactivity: (+) human and canine TLR2 Application(s): FC (intracellular and cell surface), ICC, IHC, IP, and WB TLR2 interacts with TLR1 and coexpression of TLR1 and TLR2 enhances the NF-kB activation in response to a...
An orally-available drug that has shown promise in the treatment of neurodegenerative diseases, including Alzheimer’s disease and Huntington’s disease.
A selective allosteric inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 240 nM.
An O-methylated anthocyanidin that exhibits chemopreventive as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells.
Cayman’s Glycerol Cell-Based Assay provides a convenient tool for studying triglycerides/fatty acid cycling and its regulation in adipocytes or hepatocytes. This kit will allow investigators to screen compounds involved in lipid storage and metabolism. Chloroquine is included in the kit as a...
A variety of natural products from plant sources, particularly flavonoids, have long been observed to have antioxidant activity with potential benefits for human health. Antioxidant triterpenes are less common. Celastrol is a triterpenoid antioxidant compound isolated from the Chinese thunder god...
13(Z)-Docosenoic acid is a 22-carbon monounsaturated fatty acid. It is found predominantly in canola oil. 13(Z)-Docosenoic acid is metabolized to oleic acid in vivo. Diets rich in 13(Z)-docosenoic acid were shown to cause heart lipidosis in experimental animals. The C-1 amide of docosenoic acid has...
A selective, nonpeptide vasopressin V2 receptor antagonist (IC50 = 3 nM) that has been shown to induce hypotonic diuresis without affecting the excretion of electrolytes in both animal and clinical models.
An Oct4-activating compound which activates expression through the Oct4 gene promoter; at 1 μM, enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells from embryonic fibroblasts expressing Oct4 with Sox2, Klf4, and c-Myc.
Raclopride is a selective dopamine D2/D3 receptor antagonist with Ki values of 1.8, 3.5, 2,400, and 18,000 nM for D2, D3, D4, and D1 receptors, respectively. It passes the blood brain barrier and can be used in in vivo...
Source: Active recombinant N-terminal His-tagged protein expressed in E. coli Mr: 44.6 kDa
An antioxidant derived from rosemary and common sage that inhibits lipid peroxidation and scavenges peroxyl radicals; cytotoxic towards various human cancer cell lines, reducing cell viability to 13-30% at 6.25 µg/ml.
An irreversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase (CSE) (IC50 value of 55 µM).
A dihydropyridine calcium channel blocker widely used as a coronary vasodilator for the treatment of hypertension and angina.
An inhibitor of ALK5, ALK4, and ALK7 (IC50s = 12, 45, and 7.5 nM, respectively); blocks the phosphorylation of Smad2/3 and inhibits TGF-β-induced epithelial-to-mesenchymal transition; used to reprogram fibroblasts into alternative lineages.
This assay was developed for screening applications in which the relative amount of PG production for a large number of cell culture samples must be determined. The antiserum used in this assay exhibits high cross reactivity for most PGs which will allow quantification of all the PGs in a given...
The active metabolite of perindopril, an ACE inhibitor that has efficacy against hypertension; specifically and competitively inhibits ACE in vitro with IC50 values ranging between 1.5 and 3.2 nM.
Immunogen: Synthetic peptide from an internal region of human CD36 Host: Rabbit Species Reactivity: (+) Human, mouse, and rat CD36 Application(s): WB Functioning as a receptor for oxidized LDL, CD36 is a type-B scavenger receptor that is necessary for the formation of foam cells in...