Cayman Chemical

A γ-secretase inhibitor that blocks Notch processing (IC₅₀ = 1.7 nM); reduces Aβ40 levels by 71% in an APP transgenic mouse model within 4 hours after a single 100 μM/kg dose.

A metabolite of EPA formed by COX and PGIS; the platelet and vascular activity of PGI3 is equivalent to that of PGI2.

A synthetic intermediate for pharmaceutical synthesis.

The cysteinyl leukotrienes (cysLTs), LTC4, LTD4, and LTE4, mediate their actions through two distinct G protein-coupled receptors. LTD4 is the preferred ligand for the cysLT1 receptor, whereas LTC4 and LTD4 bind with approximately equal affinity to the cysLT2 receptor. MK-571 is a selective, orally...

A central nervous system modulator that is used to experimentally induce seizures in animals; used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures.

An amide derivative that selectively activates the HAT p300, with maximal activation at 275 µM.

A long-acting and potent IP receptor agonist prodrug (Ki = 20 nM).

A c-8 epimer bimatoprost (free acid).

A fluorescent DAG analog; may be used to study interactions with proteins, utilization by cells and liposomes, and for the development of assays for lipid metabolism.

Antigen: recombinant human PrP Host: mouse, clone 8G8 Application(s): IHC

Streptavidin HRP Binding Moiety: Streptavidin Enzyme: Horseradish Peroxidase Uses: Western blot detection. Recommended dilution of 1:500-1:10,000. Starting dilution: 1:2,000.

A COX-2-selective NSAID (IC₅₀s = 11.8 and 143 μM for COX-2 and COX-1, in vitro); inhibits acute exudation and leukocyte migration as well as prevents bone and cartilage destruction in adjuvant arthritis animals models.

A dihydrofolate reductase inhibitor that prevents the production of tetrahydrofolic acid in P. falciparum and other protozoa; displays a prophylactic effect (ED₅₀ = 0.5 mg/kg) in in vivo antimalarial mouse models.

An inhibitor of FAS-II, blocking fatty acid synthesis in S. aureus and E. coli with IC₅₀ values of 11.4 and 35.3 µg/ml, respectively; inhibits the growth of S. aureus and premeable E. coli strains with MICs ranging from 0.2-0.4 µg/ml.

A degradation product of erythromycin that does not possess antibiotic activity and can be used as an analytical standard for erythromycin A stability studies.

A potent FLAP antagonist that prevents 5-LO activation in vivo; inhibits LT biosynthesis in leukocytes with an IC50 value of 2.5 nM.

An ATP-competitive Chk1 inhibitor (Ki = 0.49 nM) that demonstrates 100-fold selectivity over Chk2; abrogates DNA damage-induced cell cycle arrest in tumor cell lines and xenografts, potentiating the antiproliferative effects of various chemotherapeutics.

A dual antagonist of both OX1R and OX2R (Kis = 0.2 and 3 nM, respectively) that demonstrates good brain penetration when administered intraperitoneally; promotes sleep, prevents drug-induced plasticity and drug relapse, and decreases fear and anxiety in response to acute episodes of stress.

A 25-C diene that is found in low abundance on cuticles of mature Drosophila females; depletion of a female-specific elongase (eloF), which leads to an increase in 7(Z),11(Z)-pentacosadiene along with a parallel decrease in 7,11-nonacosadiene, significantly reduces copulation in Drosophila.

Immunogen: recombinant adenovirus expressing full-length mouse CD364 Host: CD36 null mouse, clone JC63.1 Species Reactivity: (+) human, mouse, and rat CD36 Application(s): FC and IF Functioning as a receptor for oxidized LDL, CD36 is a type-B scavenger receptor that is necessary for the formation of...

Scavenges oxygen radicals and reduces the production of ROS by inhibiting neutrophil activity; attenuates respiratory burst in rat peripheral neutrophils via suppression of NADPH oxidase (39% inhibition at 30 µg/ml) and inhibition of cytosolic calcium release from intracellular stores (36%...

A competitive mGluR1 antagonist (Ki = 298 μM; IC₅₀ = 1 mM for rat mGluR1α when challenged with glutamate); at concentrations from 10-300 μM, used to characterize the role of mGluR in LTP in the hippocampus in a model of learning and memory, the release of glutamate in...

A selective, mechanism-based inhibitor of MMP-2 and MMP-9 (Kis = 28 and 400 nM, respectively); a monohydroxylated metabolite has greater inhibitory activity (Kis = 6 and 160 nM for MMP-2 and MMP-9, respectively); can cross the blood-brain barrier.

A cell-permeable aromatic amino-fluorescein derivative that can be oxidized and converted to fluorescein by ROS such as the hydroxyl radical, peroxynitrite, and ROS generated from a peroxidase/H2O2 system.