Cayman Chemical

Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. 5-trans Latanoprost is an isomer of latanoprost wherein the double bond between carbons 5 and 6 has been changed from cis (Z) to trans (E). The trans isomer of latanoprost occurs as an...

A selective inhibitor of SPHK 1, a sphingosine kinase over expressed in several forms of cancer, both in vitro (IC₅₀ = 3.3 μM) and in U937 cells overexpressing human SPHK 1 (70% inhibition at 5 μM); has no inhibitory effect on SPHK 2 either in vitro or in cells.

N-Pivaloylaniline is a synthetic intermediate useful for pharmaceutical synthesis.

Antigen: hamster brain SAF Host: mouse, clone SAF 54 Isotype: IgG Application(s): IHC

The early stage of atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall. CAY10487 inhibits formation of fatty streak lesions of the thoracic aorta in high cholesterol-fed rabbits without affecting plasma lipid profiles or...

A colchicine derivative that inhibits tubulin polymerization (IC₅₀ = 2.1 μM) with low toxicity; suppresses microtubule dynamicity, inhibits cell migration, blocks microtubule assembly, and arrests cells in metaphase; used to synchronize cells and for karyotyping in cytogenetic studies.

Anoninvasive, intracellular calcium indicator that is UV light-excitable; spectral properties in the presence of low calcium concentrations (excitation max = 362 nm, emission max = 512 nm) differ from those during high calcium conditions (excitation ma

An inhibitor of PARPs (IC₅₀ = 400 nM); enhances the cytotoxicity of γ-irradiation and certain anticancer drugs; also used to study the regulation of DNA repair by PARP enzymes.

An oxidized pterin that binds to one of two active sites on XO, resulting in “hetero-substrate” inhibition at nanomolar concentrations; converted by XO to 6-carboxylpterin and H₂O₂, acting as an intracellular generator of H₂O₂ in cells...

Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were isolated and purified from oxLDL and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid...

A major urinary metabolite of PGE2 that is excreted in guinea pig urine at a concentration range of 1.34-2.74.

An inhibitor of long fatty acid acyl-CoA synthetase (IC50 = 6.3 μM in Raji cells) that interferes with lipid metabolism by inhibiting the de novo synthesis of triglycerides, diglycerides, and cholesterol esters; acts as a hypotensive vasodilator.

The major metabolite of the gastric proton pump inhibitor, omeprazole; produced by CYP3A4 sulfoxidation of esomeprazole.

A cell-permeant acetyloxy-methyl ester compound that is converted to the fluorescent calcium indicator Cal Green™ 1 by intracellular esterases.

An aminonucleoside antibiotic that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains; used in assays for peptide-bond formation and elongation and also often used as selective agent in cell culture systems.

A chemiluminescent probe for superoxide production by activated leukocytes.

An anti-ulcer chalcone derivative; blocks inflammation, inducing HO-1 and VEGF expression in gastric epithelial cells; promotes gastric ulcer healing following eradication therapy for H. pylori.

An anti-obesity drug that inhibits gastric, pancreatic, and carboxyl ester lipases, preventing hydrolysis of triglycerides to free fatty acids and monoglycerides; potently inhibits human recombinant DAGLα (IC50 = 60 nM) and at 1 µM inhibits the formation of 2-AG in intact cells.

Antigen: human TLR7 amino acids 706-728 Host: rabbit Cross Reactivity: (+) human, mouse, and rat TLR7 Application(s): FC (intracellular and cell surface), ICC, IHC (frozen and paraffin-embedded sections), IP, and WB Stimulation of the NF-κB signaling pathway by TLR7 suggests that it plays a...

Double bond isomer of trans-resveratrol, the more often studied and naturally abundant of the two resveratrol isomers; exhibits antioxidant activity in the micromolar range similar to that observed with trans-resveratrol.

A member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.

A plant lectin that selectively cross-links cell-surface glycoproteins and affects the initiation of cell agglutination, mitogenesis, and apoptosis; widely used in affinity chromatography purifications of various glycoproteins and cellular structures; also used to induce liver injury in experimental...

A hepatic metabolite of zearalenone that is a less potent agonist of estrogen receptors than the parent compound.

An irreversible inhibitor of caspase-10 and related caspases that at 10 µM prevents Bid cleavage into its active form, caspase cascade activation, and apoptosis in Jurkat T lymphoma cells.