Cayman Chemical

PLC catalyzes the hydrolysis of phosphatidyl inositol (4,5) bisphosphate (PIP2) on the cytoplasmic side of the cell membrane to yield diacylglycerol and inositol-1,4,5-triphosphate (IP3). This reaction initiates a well-known signal transduction pathway common to most cells. PLC thio-PIP2 is an...

A synthetic, tridentate iron-selective chelator that dramatically reduces iron in the liver and blood, particularly during transfusional iron overload; orally bioavailable, effectively reducing liver, serum, and cardiac iron concentration in conditions requiring blood transfusions.

A fluoroquinolone antibiotic which inhibits bacterial DNA gyrase (IC₅₀ = 0.109 μg/ml) and topoisomerase IV (IC₅₀ = 13.8 μg/ml); when used as a broad-spectrum oral antibiotic, can produce dysglycemia in older adults; useful for resolving bacterial conjunctivitis.

An N-acylethanolamide that inhibits dietary-restriction-induced lifespan extension in wild type and TOR pathway mutant nematodes; also has anti-inflammatory properties, suppressing the expression of IL-6 and MCP-1 in 3T3-L1 adipocytes in response to lipopolysaccharide.

Cayman’s 7-AAD/CFSE Cell-Mediated Cytotoxicity Assay Kit employs CFSE to label target cells within the mixed cell population and 7-AAD to label dead cells. This kit provides an improvement over the traditional 51chromium (51Cr) release assay to assess cell-mediated cytotoxicity. CFSE labeling...

TBS-polysorbate stock solution (10X, pH 7.4) contains a concentrated solution of filtered TBS-polysorbate.

A precursor of cysteine formed in the methionine transsulfuration pathway; deficiency can indicate the presence of metabolic disorders such as cystathioninuria.

A nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-α (IC₅₀s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC₅₀ = 5 nM) as well as various other leukemias and solid tumors.

Antigen: human GPR120 amino acids 247-258 Host: rabbit Cross Reactivity: (+) human GPR120 Application(s): ELISA and WB

A monosaccharide derivative of glucose that is released by the action of O-GlcNAcase, in mammalian systems, from proteins that have been post-translationally modified with O-GlcNAc; also is the monomeric unit of chitin, which is found in fungi and many inverebrates, including crustaceans, insects,...

A potent and selective inhibitor of neutrophil elastase (IC₅₀ = 44 nM); effective in vivo, blocking elastase-dependent acute lung injury.

This nuclear receptor assay system utilizes proprietary human cells engineered to provide constitutive, high-level expression of the full-length human progesterone receptor (NR3C3), a ligand-dependent transcription factor commonly referred to as PGR. INDIGO's Reporter Cells include the...

13,14-dihydro-15-keto PGJ2 is the dehydration product of 13,14-dihydro-15-keto PGD2 and is a presumed metabolite of PGJ2 via the 15-hydroxy PG dehydrogenase pathway. There are no published studies of the pharmacological properties or the formation of 13,14-dihydro-15-keto PGJ2 in vivo.

An inhibitor of Raf-1 and B-Raf (IC50 = 6 and 22 nM, respectively), as well as several receptor tyrosine kinases, including VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC50 = 90, 15, 20, 57, and 58 nM, respectively); inhibits tumor angiogenesis and induces tumor cell apoptosis, particularly in...

A thiazolamine that inhibits LTB4 synthesis in human neutrophils (IC₅₀ = ~0.5 µM) and conversion of LTA4 to LTB4 by purified LTA4 hydrolase (Ki = 2.3 µM); does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA4 hydrolase.

A competitive inhibitor of PC-PLC (Ki = 6.4 µM); also reduces sphingomyelin synthase activity, both in membrane preparations (IC₅₀ = 100 µg/ml) and in cells; has antioxidant, antiviral, and anti-tumor activities.

A PARP inhibitor that demonstrates a modest preference for PARP2 over PARP1 (IC₅₀s = 0.3 and 8 µM, respectively).

A selective inhibitor of Mps1 kinase (IC₅₀ = 367 nM); disrupts the recruitment of Mad2 to kinetochores and increases the frequency of multipolar mitosis in U2OS cells.

Molecular Formula C₉H₁₅N₃O • 2HCl Formula Weight 254.2

An internal standard for the quantification of 4(Z),7(Z)-decadienoic acid by GC- or LC-MS.

A potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM; R enantiomer of CAY10597 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD2 with an IC50 value of 40 nM.

Source: Recombinant protein expressed in E. coli Mr: 13.7 kDa. Histone 2H2B is one of the core nucleosomal histones. It undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.

A selective inhibitor of HDAC3 (IC₅₀ = 0.08 µM) that does not affect other HDACs at concentrations up to 15 µM; enhances long-term object memory acquisition/consolidation in mice; induces apoptosis of cutaneous T cell lymphoma cells by disrupting their DNA replication...

An orally available PARP1 and PARP2 inhibitor (Kis = 1.2 and 0.85 nM, respectively); selectively targets tumor cells with BRCA1, BRCA2, or PTEN gene mutations and elicits antitumor activity in xenografted tumors.